ID G3SQ73_LOXAF Unreviewed; 335 AA.
AC G3SQ73;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 58.
DE RecName: Full=Lysophosphatidylserine lipase ABHD12 {ECO:0000256|ARBA:ARBA00015438};
DE EC=3.1.1.23 {ECO:0000256|ARBA:ARBA00013254};
DE AltName: Full=2-arachidonoylglycerol hydrolase ABHD12 {ECO:0000256|ARBA:ARBA00033386};
DE AltName: Full=Abhydrolase domain-containing protein 12 {ECO:0000256|ARBA:ARBA00032497};
DE AltName: Full=Monoacylglycerol lipase ABHD12 {ECO:0000256|ARBA:ARBA00030575};
DE AltName: Full=Oxidized phosphatidylserine lipase ABHD12 {ECO:0000256|ARBA:ARBA00030502};
GN Name=ABHD12 {ECO:0000313|Ensembl:ENSLAFP00000001927.3};
OS Loxodonta africana (African elephant).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta.
OX NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000001927.3, ECO:0000313|Proteomes:UP000007646};
RN [1] {ECO:0000313|Ensembl:ENSLAFP00000001927.3, ECO:0000313|Proteomes:UP000007646}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000001927.3,
RC ECO:0000313|Proteomes:UP000007646};
RA Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Loxodonta africana (African elephant).";
RL Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLAFP00000001927.3}
RP IDENTIFICATION.
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000001927.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Hydrolyzes glycerol monoesters of long-chain fatty acids.;
CC EC=3.1.1.23; Evidence={ECO:0000256|ARBA:ARBA00001613};
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004389}; Single-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004389}. Membrane
CC {ECO:0000256|ARBA:ARBA00004167}; Single-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004167}.
CC -!- SIMILARITY: Belongs to the serine esterase family.
CC {ECO:0000256|ARBA:ARBA00006584}.
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DR AlphaFoldDB; G3SQ73; -.
DR STRING; 9785.ENSLAFP00000001927; -.
DR ESTHER; loxaf-g3sq73; ABHD12-PHARC.
DR Ensembl; ENSLAFT00000002307.3; ENSLAFP00000001927.3; ENSLAFG00000002307.3.
DR eggNOG; KOG1552; Eukaryota.
DR GeneTree; ENSGT00940000160517; -.
DR HOGENOM; CLU_029375_1_0_1; -.
DR InParanoid; G3SQ73; -.
DR OMA; VEFHRFE; -.
DR TreeFam; TF315122; -.
DR Proteomes; UP000007646; Unassembled WGS sequence.
DR GO; GO:0032281; C:AMPA glutamate receptor complex; IEA:Ensembl.
DR GO; GO:0032839; C:dendrite cytoplasm; IEA:Ensembl.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0047372; F:acylglycerol lipase activity; IEA:UniProtKB-EC.
DR GO; GO:0004622; F:lysophospholipase activity; IEA:Ensembl.
DR GO; GO:0008474; F:palmitoyl-(protein) hydrolase activity; IEA:Ensembl.
DR GO; GO:0007628; P:adult walking behavior; IEA:Ensembl.
DR GO; GO:0052651; P:monoacylglycerol catabolic process; IEA:Ensembl.
DR GO; GO:0006660; P:phosphatidylserine catabolic process; IEA:Ensembl.
DR GO; GO:0050727; P:regulation of inflammatory response; IEA:Ensembl.
DR GO; GO:0010996; P:response to auditory stimulus; IEA:Ensembl.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR000073; AB_hydrolase_1.
DR PANTHER; PTHR12277; ALPHA/BETA HYDROLASE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR12277:SF61; LYSOPHOSPHATIDYLSERINE LIPASE ABHD12; 1.
DR Pfam; PF00561; Abhydrolase_1; 1.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000007646};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..29
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 106..211
FT /note="AB hydrolase-1"
FT /evidence="ECO:0000259|Pfam:PF00561"
SQ SEQUENCE 335 AA; 38763 MW; 306F9D63B097BA1D CRC64;
RRKGLWLRLR KILLCVLGLY VAIPFLVKLC PGIQAKLIFL NFVRIPYFID LKKPQDQGLN
HTCNYYLQPE EDVTIGVWHT VPAVWWRNAQ GKDQMWYEDT LASNHPIVLY LHGNAGTRGG
DHRVELYKVL SSLGYHVVTF DYRGWGDSAG TPSEQGMTYD ALHVFDWIKA RSGDNPVYIW
GHSLGTGVAT NLVRRLCERE TPPDALILES PFTNIREEAK SHPFSVIYRY FPGFDWFFLD
PITSSGIKFA NDENVKHISC SLLILHAEDD PVVPFQLGRK LYNIAAPSRS FRDFKVQFIP
FHSDLGYRHK YIYKSPELPR ILREFLGKSE QERHH
//