ID G3SQB8_LOXAF Unreviewed; 205 AA.
AC G3SQB8;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 55.
DE SubName: Full=PYM homolog 1, exon junction complex associated factor {ECO:0000313|Ensembl:ENSLAFP00000001982.3};
GN Name=PYM1 {ECO:0000313|Ensembl:ENSLAFP00000001982.3};
OS Loxodonta africana (African elephant).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta.
OX NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000001982.3, ECO:0000313|Proteomes:UP000007646};
RN [1] {ECO:0000313|Ensembl:ENSLAFP00000001982.3, ECO:0000313|Proteomes:UP000007646}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000001982.3,
RC ECO:0000313|Proteomes:UP000007646};
RA Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Loxodonta africana (African elephant).";
RL Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLAFP00000001982.3}
RP IDENTIFICATION.
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000001982.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBUNIT: Interacts (via N-terminus) with magoh and rbm8a; the
CC interaction is direct. Associates (eIF2A-like region) with the 40S
CC ribosomal subunit and the 48S preinitiation complex.
CC {ECO:0000256|ARBA:ARBA00025900}.
CC -!- SIMILARITY: Belongs to the pym family. {ECO:0000256|ARBA:ARBA00009394}.
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DR AlphaFoldDB; G3SQB8; -.
DR STRING; 9785.ENSLAFP00000001982; -.
DR Ensembl; ENSLAFT00000002369.3; ENSLAFP00000001982.3; ENSLAFG00000002369.4.
DR eggNOG; KOG4325; Eukaryota.
DR GeneTree; ENSGT00730000111107; -.
DR InParanoid; G3SQB8; -.
DR OMA; IPGCADS; -.
DR TreeFam; TF324615; -.
DR Proteomes; UP000007646; Unassembled WGS sequence.
DR GO; GO:0030054; C:cell junction; IEA:Ensembl.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0035145; C:exon-exon junction complex; IEA:Ensembl.
DR GO; GO:0005730; C:nucleolus; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0043022; F:ribosome binding; IEA:Ensembl.
DR GO; GO:1903259; P:exon-exon junction complex disassembly; IEA:Ensembl.
DR GO; GO:0000184; P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; IEA:Ensembl.
DR GO; GO:0045727; P:positive regulation of translation; IEA:Ensembl.
DR InterPro; IPR039333; PYM1.
DR InterPro; IPR015362; WIBG_mago-bd.
DR InterPro; IPR036348; WIBG_N_sf.
DR PANTHER; PTHR22959:SF0; PARTNER OF Y14 AND MAGO; 1.
DR PANTHER; PTHR22959; PYM PROTEIN; 1.
DR Pfam; PF09282; Mago-bind; 1.
DR SMART; SM01273; Mago-bind; 1.
DR SUPFAM; SSF101931; Pym (Within the bgcn gene intron protein, WIBG), N-terminal domain; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000007646}.
FT DOMAIN 13..39
FT /note="WIBG Mago-binding"
FT /evidence="ECO:0000259|SMART:SM01273"
FT REGION 1..33
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 56..152
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..24
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 117..146
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 205 AA; 22891 MW; 71D33F9777004449 CRC64;
TEPYSTPAAL KSSGKYIAST QRPDGTWRKQ RRVKEGYVPQ EEVPVYENKY VKFFKSKPEL
PPGLSPEAAV PATPCRPEGG EPGLSKTAKR NLKRKEKRRQ QQEKGEAEAL SRTLEKVSLG
ETAQLPNASQ GSRAVPTAIS DQSDSAATTE KAKKIKNLKK KLRQVEELQQ RIQAGEISQP
SKEQLEKLAR RRALEEELED LELGL
//
