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Database: UniProt
Entry: G3SRN3_LOXAF
LinkDB: G3SRN3_LOXAF
Original site: G3SRN3_LOXAF 
ID   G3SRN3_LOXAF            Unreviewed;      1054 AA.
AC   G3SRN3;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   27-SEP-2017, entry version 50.
DE   SubName: Full=Potassium voltage-gated channel subfamily H member 2 {ECO:0000313|Ensembl:ENSLAFP00000002563};
GN   Name=KCNH2 {ECO:0000313|Ensembl:ENSLAFP00000002563};
OS   Loxodonta africana (African elephant).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta.
OX   NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000002563, ECO:0000313|Proteomes:UP000007646};
RN   [1] {ECO:0000313|Ensembl:ENSLAFP00000002563}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000002563};
RA   Di Palma F., Heiman D., Young S., Johnson J., Lander E.S.,
RA   Lindblad-Toh K.;
RT   "The Genome Sequence of Loxodonta africana (African elephant).";
RL   Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSLAFP00000002563}
RP   IDENTIFICATION.
RC   STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000002563};
RG   Ensembl;
RL   Submitted (SEP-2011) to UniProtKB.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSLAFP00000002563}.
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DR   STRING; 9785.ENSLAFP00000002563; -.
DR   Ensembl; ENSLAFT00000003073; ENSLAFP00000002563; ENSLAFG00000003073.
DR   eggNOG; KOG0498; Eukaryota.
DR   eggNOG; ENOG410XPSE; LUCA.
DR   GeneTree; ENSGT00760000118772; -.
DR   InParanoid; G3SRN3; -.
DR   OMA; GPWGESP; -.
DR   OrthoDB; EOG091G024C; -.
DR   TreeFam; TF313130; -.
DR   Proteomes; UP000007646; Unassembled WGS sequence.
DR   GO; GO:0009986; C:cell surface; IEA:Ensembl.
DR   GO; GO:1902937; C:inward rectifier potassium channel complex; IEA:Ensembl.
DR   GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:Ensembl.
DR   GO; GO:0055131; F:C3HC4-type RING finger domain binding; IEA:Ensembl.
DR   GO; GO:0005251; F:delayed rectifier potassium channel activity; IEA:Ensembl.
DR   GO; GO:0005242; F:inward rectifier potassium channel activity; IEA:Ensembl.
DR   GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR   GO; GO:0042803; F:protein homodimerization activity; IEA:Ensembl.
DR   GO; GO:0097110; F:scaffold protein binding; IEA:Ensembl.
DR   GO; GO:0031625; F:ubiquitin protein ligase binding; IEA:Ensembl.
DR   GO; GO:1902282; F:voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization; IEA:Ensembl.
DR   GO; GO:0035690; P:cellular response to drug; IEA:Ensembl.
DR   GO; GO:0086010; P:membrane depolarization during action potential; IEA:Ensembl.
DR   GO; GO:1902303; P:negative regulation of potassium ion export; IEA:Ensembl.
DR   GO; GO:1901381; P:positive regulation of potassium ion transmembrane transport; IEA:Ensembl.
DR   GO; GO:0097623; P:potassium ion export across plasma membrane; IEA:Ensembl.
DR   GO; GO:0055075; P:potassium ion homeostasis; IEA:Ensembl.
DR   GO; GO:0086091; P:regulation of heart rate by cardiac conduction; IEA:Ensembl.
DR   GO; GO:0060307; P:regulation of ventricular cardiac muscle cell membrane repolarization; IEA:Ensembl.
DR   CDD; cd00130; PAS; 1.
DR   Gene3D; 2.60.120.10; -; 1.
DR   InterPro; IPR018490; cNMP-bd-like.
DR   InterPro; IPR000595; cNMP-bd_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR003938; K_chnl_volt-dep_EAG/ELK/ERG.
DR   InterPro; IPR001610; PAC.
DR   InterPro; IPR000014; PAS.
DR   InterPro; IPR000700; PAS-assoc_C.
DR   InterPro; IPR014710; RmlC-like_jellyroll.
DR   Pfam; PF00027; cNMP_binding; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF13426; PAS_9; 1.
DR   PRINTS; PR01463; EAGCHANLFMLY.
DR   SMART; SM00100; cNMP; 1.
DR   SMART; SM00086; PAC; 1.
DR   SUPFAM; SSF51206; SSF51206; 1.
DR   SUPFAM; SSF55785; SSF55785; 1.
DR   TIGRFAMs; TIGR00229; sensory_box; 1.
DR   PROSITE; PS50042; CNMP_BINDING_3; 1.
DR   PROSITE; PS50113; PAC; 1.
DR   PROSITE; PS50112; PAS; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000007646};
KW   Ion channel {ECO:0000256|SAAS:SAAS00091826};
KW   Ion transport {ECO:0000256|SAAS:SAAS00502700};
KW   Membrane {ECO:0000256|SAAS:SAAS00502630, ECO:0000256|SAM:Phobius};
KW   Potassium {ECO:0000256|SAAS:SAAS00807593};
KW   Potassium channel {ECO:0000256|SAAS:SAAS00807732};
KW   Potassium transport {ECO:0000256|SAAS:SAAS00807568};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007646};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00137614,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00137754,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|SAAS:SAAS00502637};
KW   Voltage-gated channel {ECO:0000256|SAAS:SAAS00807693}.
FT   TRANSMEM    410    431       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    543    569       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       40     69       PAS. {ECO:0000259|PROSITE:PS50112}.
FT   DOMAIN       91    143       PAC. {ECO:0000259|PROSITE:PS50113}.
FT   DOMAIN      638    738       Cyclic nucleotide-binding.
FT                                {ECO:0000259|PROSITE:PS50042}.
FT   COILED      930    957       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1054 AA;  114715 MW;  4AACEC236A9950EF CRC64;
     RCGRGPVAPQ NTFLDIIIRK FEGQSRKFII ANARVENCAV IYCNDGFCEL CGYSRAEVMQ
     RPCTCDFLHG PRTQRRAAAQ IAQALLGAEE RKVEIAFYRK DGSCFLCLVD VVPVKNEDGA
     VIMFILNFEV VMEKDMVGSP ARDTNHRGPP TSWLAPGRAK TFRLKLPALL ALTARQSSVR
     SGGTGGSGAP GAVVVDVDLT PTAPSESLAL DEVTALDNHV VGPGPAEEQR ALVGPGSPPS
     RAPAPHSPLA HSLNPDASGS SCSLARTRSR ESFASVRRAS SADDIEAMRA GALPPPPPRH
     ASTGAMHPLR SGLLNSTSDS DLVRYRTISK IPQITLNFVD LKGDPFLASP TSDREIIAPK
     IKERTHNVTE KVTQVLSLGA DVLPEYKLQA PRIHRWTILH YSPFKAVWDW LILLLVIYTA
     VFTPYSAAFL LKETEEGPPA PDCGYACQPL AVVDLIVDIM FIVDILINFR TTYVNANEEV
     VSHPGRIAVH YFKGWFLIDM VAAIPFDLLI FGSGSEELIG LLKTARLLRL VRVARKLDRY
     SEYGAAVLFL LMCTFALIAH WLACIWYAIG NMEQPHMDSR IGWLHNLGDQ IGKPYNSSGL
     GGPSIKDKYV TALYFTFSSL QPDICLHLNR SLLQHCKPFR GATKGCLRAL AMKFKTTHAP
     PGDTLVHAGD LLTALYFISR GSIEILRGDV VVAILGKNDI FGEPLNLYAR PGKSNGDVRA
     LTYCDLHKIH RDDLLEVLDM YPEFSDHFWS SLEITFNLRD TNMIPGSPGS TELDGFSRQR
     RRKLSFRRRT DKDVEQPGEV SALGPGRAGA GPSDRGRPGG PWGESPSSGP SSPESSEDEG
     PGRSSSPLRL VPFSSPRAPG ELPGGEPLTE DCEKRSDTCN PLSGAFSGVS NIFSFWGDSR
     GRQYQELPRC PATTPSLLNI PLSSPGRRPR GDVESRLDAL QRQLNRLETR LSADMATVLQ
     LLQRQMTLVP PAYSAVTSPG PGPTSASPLL PVSPIPILTL DSLSQVSQFM ACEELPPGAP
     ELPQDGPTRR LSLPGQLGAL TSQPLHRHGS DPGS
//
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