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Database: UniProt
Entry: G3SRU1_LOXAF
LinkDB: G3SRU1_LOXAF
Original site: G3SRU1_LOXAF 
ID   G3SRU1_LOXAF            Unreviewed;      1408 AA.
AC   G3SRU1;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   24-JAN-2024, entry version 79.
DE   SubName: Full=Nidogen 2 {ECO:0000313|Ensembl:ENSLAFP00000002630.3};
GN   Name=NID2 {ECO:0000313|Ensembl:ENSLAFP00000002630.3};
OS   Loxodonta africana (African elephant).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta.
OX   NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000002630.3, ECO:0000313|Proteomes:UP000007646};
RN   [1] {ECO:0000313|Ensembl:ENSLAFP00000002630.3, ECO:0000313|Proteomes:UP000007646}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000002630.3,
RC   ECO:0000313|Proteomes:UP000007646};
RA   Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., Lindblad-Toh K.;
RT   "The Genome Sequence of Loxodonta africana (African elephant).";
RL   Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSLAFP00000002630.3}
RP   IDENTIFICATION.
RC   STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000002630.3};
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004370}.
CC       Secreted, extracellular space, extracellular matrix, basement membrane
CC       {ECO:0000256|ARBA:ARBA00004302}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC       feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR   STRING; 9785.ENSLAFP00000002630; -.
DR   Ensembl; ENSLAFT00000003167.3; ENSLAFP00000002630.3; ENSLAFG00000003163.3.
DR   eggNOG; KOG1214; Eukaryota.
DR   GeneTree; ENSGT00940000157901; -.
DR   HOGENOM; CLU_003163_1_0_1; -.
DR   InParanoid; G3SRU1; -.
DR   OMA; TCEHNHG; -.
DR   TreeFam; TF320666; -.
DR   Proteomes; UP000007646; Unassembled WGS sequence.
DR   GO; GO:0005604; C:basement membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0007160; P:cell-matrix adhesion; IEA:InterPro.
DR   CDD; cd00054; EGF_CA; 3.
DR   CDD; cd00255; nidG2; 1.
DR   CDD; cd00191; TY; 2.
DR   Gene3D; 2.40.155.10; Green fluorescent protein; 1.
DR   Gene3D; 2.10.25.10; Laminin; 4.
DR   Gene3D; 4.10.800.10; Thyroglobulin type-1; 2.
DR   Gene3D; 2.120.10.30; TolB, C-terminal domain; 1.
DR   InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR   InterPro; IPR026823; cEGF.
DR   InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR   InterPro; IPR000742; EGF-like_dom.
DR   InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR   InterPro; IPR018097; EGF_Ca-bd_CS.
DR   InterPro; IPR024731; EGF_dom.
DR   InterPro; IPR006605; G2_nidogen/fibulin_G2F.
DR   InterPro; IPR009017; GFP.
DR   InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR   InterPro; IPR000033; LDLR_classB_rpt.
DR   InterPro; IPR003886; NIDO_dom.
DR   InterPro; IPR000716; Thyroglobulin_1.
DR   InterPro; IPR036857; Thyroglobulin_1_sf.
DR   PANTHER; PTHR12352:SF3; NIDOGEN-2; 1.
DR   PANTHER; PTHR12352; SECRETED MODULAR CALCIUM-BINDING PROTEIN; 1.
DR   Pfam; PF12662; cEGF; 1.
DR   Pfam; PF12947; EGF_3; 1.
DR   Pfam; PF07645; EGF_CA; 1.
DR   Pfam; PF07474; G2F; 1.
DR   Pfam; PF00058; Ldl_recept_b; 2.
DR   Pfam; PF06119; NIDO; 1.
DR   Pfam; PF00086; Thyroglobulin_1; 2.
DR   SMART; SM00181; EGF; 5.
DR   SMART; SM00179; EGF_CA; 4.
DR   SMART; SM00682; G2F; 1.
DR   SMART; SM00135; LY; 4.
DR   SMART; SM00539; NIDO; 1.
DR   SMART; SM00211; TY; 2.
DR   SUPFAM; SSF57196; EGF/Laminin; 1.
DR   SUPFAM; SSF54511; GFP-like; 1.
DR   SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR   SUPFAM; SSF57610; Thyroglobulin type-1 domain; 2.
DR   SUPFAM; SSF63825; YWTD domain; 1.
DR   PROSITE; PS00010; ASX_HYDROXYL; 2.
DR   PROSITE; PS01186; EGF_2; 3.
DR   PROSITE; PS50026; EGF_3; 4.
DR   PROSITE; PS01187; EGF_CA; 1.
DR   PROSITE; PS51120; LDLRB; 3.
DR   PROSITE; PS51220; NIDO; 1.
DR   PROSITE; PS50993; NIDOGEN_G2; 1.
DR   PROSITE; PS00484; THYROGLOBULIN_1_1; 2.
DR   PROSITE; PS51162; THYROGLOBULIN_1_2; 2.
PE   4: Predicted;
KW   Basement membrane {ECO:0000256|ARBA:ARBA00022869};
KW   Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW   ProRule:PRU00500};
KW   EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW   ProRule:PRU00076}; Extracellular matrix {ECO:0000256|ARBA:ARBA00022869};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007646};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Secreted {ECO:0000256|ARBA:ARBA00022525}.
FT   DOMAIN          111..277
FT                   /note="NIDO"
FT                   /evidence="ECO:0000259|PROSITE:PS51220"
FT   DOMAIN          555..785
FT                   /note="Nidogen G2 beta-barrel"
FT                   /evidence="ECO:0000259|PROSITE:PS50993"
FT   DOMAIN          786..827
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50026"
FT   DOMAIN          828..870
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50026"
FT   DOMAIN          875..918
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50026"
FT   DOMAIN          919..955
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50026"
FT   DOMAIN          969..1037
FT                   /note="Thyroglobulin type-1"
FT                   /evidence="ECO:0000259|PROSITE:PS51162"
FT   DOMAIN          1049..1117
FT                   /note="Thyroglobulin type-1"
FT                   /evidence="ECO:0000259|PROSITE:PS51162"
FT   REPEAT          1187..1230
FT                   /note="LDL-receptor class B"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT   REPEAT          1231..1273
FT                   /note="LDL-receptor class B"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT   REPEAT          1274..1318
FT                   /note="LDL-receptor class B"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT   REGION          1..65
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          325..467
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1025..1047
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   DISULFID        1006..1013
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00500"
FT   DISULFID        1087..1094
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00500"
SQ   SEQUENCE   1408 AA;  154204 MW;  BFA191E9A4F67A9E CRC64;
     AGAQPLVGWL AGPGTRSATG QHTGRSRVAA LPPRRGLPLT GRRGGDRSLA GRRMPRPSSG
     EAGNPPLHFY ESQVQGPSYV GTNGIISTQD FPRETQYVDD DFPTDFPAIA PFLADIDTSQ
     GRGRILYRED TSPAVLGLAA RYVRAGFPRS ITRFAPTHAF LATWEQVGAY EEVTRGAPPS
     GELNTFQAVL VSDESDTYAL FLYPANGLQF FGTRPKESYN VQLELPARVG FCRGEADDLK
     REGPYFSLTS TEQSVKNLYQ LSNLGISGVW AFHIGSTSPL DNVRPATLGG DLSKAHSLAS
     LEHSFSHTAA LESDYTEDNL DYYDENEEEA EYPPSEPEEA GNGHGSVDVS FPVKVDSRPS
     GGDVSPPNSD LAALLPHPTP SDWPFYPETE SATWDPQTKE GKIGTPGLNG RVEASEQIET
     RSSAPPETDR DSLDPPQKAL PYAENEHLQP YPDGGVVPSE TDVPAARPGE VVPPHYPLPD
     HTAPRSSRRF VVGVEDNISS NTEVFTYNAA NKETCEQNHR QCSQHAFCTD YTTGFCCHCQ
     TRFYGNGKYC LPEGAPQRVN GKVSGHLRVG HTPVHFTDVD LHAYIVGNDG RAYTAISHIP
     QPAAQALLPL TPIGGLFGWL FALEKPGSEN GFSITGATFT HDMEVTFYPG EEKVHITQTA
     EGLDPENYLS VKTNIQGQVP YIPANFTAHI APYKELYHYS DSVVTSTSSR DYSLTFGAIN
     QTLSYRIHQN ITYQTCRHAP RHQAIPTTQQ LNVDRAFALY NDEERVLRFA VTNQVGHVEV
     DSDPAPVNPC YDGSHTCDTT AQCHPGTGLA YTCECAPGYQ GDGRNCVDVN ECATGVHHCG
     PNSVCINLKG SYKCECRSGY EFADDRHTCI VIAPPPNPCE DGSHTCAPAG QARCIHHGGS
     TFTCACLPGY VGTGHQCTDV DECLENRCHP AATCYNTPGS FSCRCQPGYH GDGFQCTPAL
     DPEDSVSGLK PCEHQQRYVQ VQPAYPGSPL HIPQCDEQGN FLPLQCHSST GFCWCVDQRG
     HEIPGTRTPP GSTPPHCGAP GSEPTQRPQT VCERWRESLL EHYGGTARDD QYVPQCDDLG
     QFIPLQCHGK SDFCWCVDKD GREVEGTRSQ PGTTPACIPT VAPPMVRPTP RPDVTPPSVG
     TFLVYAQGQQ IGHLPLNGTR LQKDAAKTLL SLHGSIVVGI DYDCRERMVY WTDVAGRTIS
     RASLEPGAEP ETVINTGLIS PEGLAIDHFR RTMYWTDSGL DKIESSKLDG SERRVLFHTE
     LVNPRAITVD PIRGNLYWTD WNREAPKIET SSLNGENRRI LVNKDIGLPN GLTFDPFSKL
     LCWADAGTKK LECTLPDGTG RRVIQHNLNY PFSIVSYADH FYHTDWRRDG VISVNKDSGQ
     FTDEYLPEQR SHLYGITAVY PYCPTGNE
//
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