ID G3SVG3_LOXAF Unreviewed; 1142 AA.
AC G3SVG3;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 75.
DE SubName: Full=Adhesion G protein-coupled receptor G6 {ECO:0000313|Ensembl:ENSLAFP00000004228.3};
GN Name=ADGRG6 {ECO:0000313|Ensembl:ENSLAFP00000004228.3};
OS Loxodonta africana (African elephant).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta.
OX NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000004228.3, ECO:0000313|Proteomes:UP000007646};
RN [1] {ECO:0000313|Ensembl:ENSLAFP00000004228.3, ECO:0000313|Proteomes:UP000007646}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000004228.3,
RC ECO:0000313|Proteomes:UP000007646};
RA Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Loxodonta africana (African elephant).";
RL Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLAFP00000004228.3}
RP IDENTIFICATION.
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000004228.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 2 family.
CC Adhesion G-protein coupled receptor (ADGR) subfamily.
CC {ECO:0000256|ARBA:ARBA00007343}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00059}.
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DR AlphaFoldDB; G3SVG3; -.
DR STRING; 9785.ENSLAFP00000004228; -.
DR Ensembl; ENSLAFT00000005053.3; ENSLAFP00000004228.3; ENSLAFG00000005050.3.
DR eggNOG; KOG3714; Eukaryota.
DR eggNOG; KOG4193; Eukaryota.
DR GeneTree; ENSGT00940000155621; -.
DR HOGENOM; CLU_002753_3_3_1; -.
DR InParanoid; G3SVG3; -.
DR OMA; AVHHPIC; -.
DR TreeFam; TF321769; -.
DR Proteomes; UP000007646; Unassembled WGS sequence.
DR GO; GO:0009986; C:cell surface; IEA:Ensembl.
DR GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:Ensembl.
DR GO; GO:0019933; P:cAMP-mediated signaling; IEA:Ensembl.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR GO; GO:0042552; P:myelination; IEA:Ensembl.
DR GO; GO:0014037; P:Schwann cell differentiation; IEA:Ensembl.
DR CDD; cd00041; CUB; 1.
DR Gene3D; 2.60.120.200; -; 1.
DR Gene3D; 2.60.220.50; -; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR Gene3D; 2.60.120.290; Spermadhesin, CUB domain; 1.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR000859; CUB_dom.
DR InterPro; IPR046338; GAIN_dom_sf.
DR InterPro; IPR017981; GPCR_2-like_7TM.
DR InterPro; IPR000832; GPCR_2_secretin-like.
DR InterPro; IPR017983; GPCR_2_secretin-like_CS.
DR InterPro; IPR000203; GPS.
DR InterPro; IPR001759; Pentraxin-related.
DR InterPro; IPR035914; Sperma_CUB_dom_sf.
DR PANTHER; PTHR12011; ADHESION G-PROTEIN COUPLED RECEPTOR; 1.
DR PANTHER; PTHR12011:SF290; ADHESION G-PROTEIN COUPLED RECEPTOR G6; 1.
DR Pfam; PF00002; 7tm_2; 1.
DR Pfam; PF00431; CUB; 1.
DR Pfam; PF01825; GPS; 1.
DR Pfam; PF00354; Pentaxin; 1.
DR PRINTS; PR00249; GPCRSECRETIN.
DR SMART; SM00042; CUB; 1.
DR SMART; SM00303; GPS; 1.
DR SMART; SM00159; PTX; 1.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR SUPFAM; SSF49854; Spermadhesin, CUB domain; 1.
DR PROSITE; PS01180; CUB; 1.
DR PROSITE; PS00650; G_PROTEIN_RECEP_F2_2; 1.
DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
DR PROSITE; PS50221; GPS; 1.
DR PROSITE; PS51828; PTX_2; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00059};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000007646};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 813..836
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 848..868
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 880..905
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 917..938
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 966..996
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1017..1036
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1042..1064
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 16..124
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 811..1065
FT /note="G-protein coupled receptors family 2 profile 2"
FT /evidence="ECO:0000259|PROSITE:PS50261"
FT REGION 1103..1142
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 69..86
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00059"
SQ SEQUENCE 1142 AA; 127274 MW; FA626A8A27CFCFC7 CRC64;
LCLSFVWPAA WGCANCRVDL SNPSGTFTSP CYPNDYPNSQ ACMWTLRAPT GYIIQITFND
FDIEEAPNCI YDSLSLDNGE SQTKFCGATA KGLSFNSSAN EMHVSFSSDF SIQKKGFNAS
YTRVAVSLRN QKVVLPQTLD AYQVSVAKSV SIPELSAFSL CFEATKIGNE DNDWTAFSYS
DASFTQLLSF GKDQRDYFLT ISGLKCSLNS VLPVKENEDI FTESFEQLCI VWNNSLGSVG
VSFKRNYEIV PCDSTISKVI PGNGKLLLGS NQNEIASLKG DIYNFRLWNF TMNSKTLSNL
SCNVKGNVVD WQNDFWNIPT LALKAENNLS CGSYLIPLPA AELASCVDLG TLCQDGIVYR
ISIVIQNILR HPEVKVQSKV AEWLNSTFQN WNYTVYVVNI SLHLSTGEDK IKVRRSIEDD
SSQVVIWALL VYNATNNVSL EGKTIQQKLL RNNESLDEGL RLYTVNVRQL DICPADEDPK
GYLWPTTRPS EYILPCNGKP GFYASRTCHR NLTNASLAYW GVPDVSNCSN DLNNVNTILN
LTGEGQNLTS ANITSIVEYV KRIVNNEENI DITLGSTLMT IFSNILTSSD SDLLESSSEA
LKTIDELAFK IDLTSTSRVN ITTRNLALGV SSLPPGTNIV SNFSIGLPSN NESYFQMDFE
SGQVNPLASV ILPPNLLENL SKEDSALVKR AQFTFFNKTG LFQDVGSQRD NLVSYVMACS
IGNITLQDLK DPVRIIIKHT RAQAVHHPIC AFWDLNKNKG FGGWNTSGCI AYKGSDESET
VCLCNHLTHF GVLMDLQGTA SQLDARNTKV LTFLTYIGCG ISAIFSAATL LTYVAFEKLR
RDYPSKILMN LSTALLFLNL IFLLDGWITS FDVDGLCTAV AALLHFFLLA TFTWMGLEAI
HMYIALVKVF NTYIRRYILK FCIIGWGLPA LVVSVVLASR NQNEVYGKES YGKEQGDEFC
WIQDPVIFYV TCAGYFGVMF FLNVAMFIVV MVQICGRNGK RSNRTLREEV LRNLRSVVSL
TFLLGMTWGF AFFAWGPLNV PFMYLFSIFN SLQGLFIFIF HCAMKENVQK QWRRHLCCGR
FRLADNSDWS KTATNIIKKS SDNLGKSLSS SSIGSNSTYL TSKSKSSSTT YFKRNSHTGE
SL
//
