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Database: UniProt
Entry: G3SVP4_LOXAF
LinkDB: G3SVP4_LOXAF
Original site: G3SVP4_LOXAF 
ID   G3SVP4_LOXAF            Unreviewed;      2597 AA.
AC   G3SVP4;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   08-NOV-2023, entry version 68.
DE   SubName: Full=ATP binding cassette subfamily A member 12 {ECO:0000313|Ensembl:ENSLAFP00000004322.4};
GN   Name=ABCA12 {ECO:0000313|Ensembl:ENSLAFP00000004322.4};
OS   Loxodonta africana (African elephant).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta.
OX   NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000004322.4, ECO:0000313|Proteomes:UP000007646};
RN   [1] {ECO:0000313|Ensembl:ENSLAFP00000004322.4, ECO:0000313|Proteomes:UP000007646}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000004322.4,
RC   ECO:0000313|Proteomes:UP000007646};
RA   Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., Lindblad-Toh K.;
RT   "The Genome Sequence of Loxodonta africana (African elephant).";
RL   Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSLAFP00000004322.4}
RP   IDENTIFICATION.
RC   STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000004322.4};
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR   STRING; 9785.ENSLAFP00000004322; -.
DR   Ensembl; ENSLAFT00000005165.4; ENSLAFP00000004322.4; ENSLAFG00000005158.4.
DR   eggNOG; KOG0059; Eukaryota.
DR   GeneTree; ENSGT00940000157295; -.
DR   HOGENOM; CLU_000604_19_7_1; -.
DR   InParanoid; G3SVP4; -.
DR   TreeFam; TF105191; -.
DR   Proteomes; UP000007646; Unassembled WGS sequence.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0097234; C:epidermal lamellar body membrane; IEA:Ensembl.
DR   GO; GO:0000139; C:Golgi membrane; IEA:Ensembl.
DR   GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR   GO; GO:0140359; F:ABC-type transporter activity; IEA:InterPro.
DR   GO; GO:0034191; F:apolipoprotein A-I receptor binding; IEA:Ensembl.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0005319; F:lipid transporter activity; IEA:Ensembl.
DR   GO; GO:0006672; P:ceramide metabolic process; IEA:Ensembl.
DR   GO; GO:0035627; P:ceramide transport; IEA:Ensembl.
DR   GO; GO:0033344; P:cholesterol efflux; IEA:Ensembl.
DR   GO; GO:0003336; P:corneocyte desquamation; IEA:Ensembl.
DR   GO; GO:0061436; P:establishment of skin barrier; IEA:Ensembl.
DR   GO; GO:0006886; P:intracellular protein transport; IEA:Ensembl.
DR   GO; GO:0031424; P:keratinization; IEA:Ensembl.
DR   GO; GO:0055088; P:lipid homeostasis; IEA:Ensembl.
DR   GO; GO:0048286; P:lung alveolus development; IEA:Ensembl.
DR   GO; GO:0033700; P:phospholipid efflux; IEA:Ensembl.
DR   GO; GO:0010875; P:positive regulation of cholesterol efflux; IEA:Ensembl.
DR   GO; GO:0032379; P:positive regulation of intracellular lipid transport; IEA:Ensembl.
DR   GO; GO:2000010; P:positive regulation of protein localization to cell surface; IEA:Ensembl.
DR   GO; GO:0072659; P:protein localization to plasma membrane; IEA:Ensembl.
DR   GO; GO:0045055; P:regulated exocytosis; IEA:Ensembl.
DR   GO; GO:0061178; P:regulation of insulin secretion involved in cellular response to glucose stimulus; IEA:Ensembl.
DR   GO; GO:0045616; P:regulation of keratinocyte differentiation; IEA:Ensembl.
DR   GO; GO:0043129; P:surfactant homeostasis; IEA:Ensembl.
DR   CDD; cd03263; ABC_subfamily_A; 2.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR013525; ABC2_TM.
DR   InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR   InterPro; IPR017871; ABC_transporter-like_CS.
DR   InterPro; IPR026082; ABCA.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR19229:SF36; ABC TRANSPORTER A FAMILY MEMBER 7-RELATED; 1.
DR   PANTHER; PTHR19229; ATP-BINDING CASSETTE TRANSPORTER SUBFAMILY A ABCA; 1.
DR   Pfam; PF12698; ABC2_membrane_3; 2.
DR   Pfam; PF00005; ABC_tran; 2.
DR   SMART; SM00382; AAA; 2.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR   PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR   PROSITE; PS50893; ABC_TRANSPORTER_2; 2.
PE   4: Predicted;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007646};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        24..43
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        1069..1092
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        1113..1135
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        1147..1171
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        1178..1198
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        1204..1221
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        1252..1273
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        1989..2011
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        2045..2062
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        2069..2089
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        2101..2125
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        2188..2209
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          1348..1579
FT                   /note="ABC transporter"
FT                   /evidence="ECO:0000259|PROSITE:PS50893"
FT   DOMAIN          2256..2491
FT                   /note="ABC transporter"
FT                   /evidence="ECO:0000259|PROSITE:PS50893"
FT   REGION          120..141
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1686..1706
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   2597 AA;  293295 MW;  6718641CF3F28421 CRC64;
     MASQLHQLRV LVWKNWLGVK RQPLWTLVLI LWPVIIFIIL AITRTKFPPT AKPTCYLAPR
     NLPSTGFFPF LQTLLCDTDS KCKNTPYGPQ DLLRRKGIDA TVFKDNEILT KSPSLEEDSN
     LSLQRTKVPG SGHTSAATVF PIPSPDLEST GTYTFNGSQV LARFLDLEKL LKQNSTSEDV
     RRELCESYPT YIADHTFSWT TLGKNVFNKF CLSNMSLLES SLQELRNQIS QISSDPNNQK
     IVFQDMVKAL SFFSQLQKQT AVWQLLSSFP NVFQNATTLS NLFGVLRKAS SALLVVQKVY
     PHVTTNKGFR TLQKSVKHLL MTLDSTTEGG SHNTTHLWNE DDGQTLSPSS LAAQLLILEN
     FEDALLNIST DSPYIPYLVC VRNITDNLAR GSQENLRLLQ STIRFRKSFL RNGSYEDSIP
     PVPEIMKSKL SQLRNLTELL CDSEMSSSIE KTCQLSNISF GDLCEENAFH VQFLEAAELA
     TEIASGLLYH ENVISEKLRN LLTGDPSKIN LNMDRFLEQA LQMNYLENIT QLMPTIEAML
     HVNNSADSSE KPGQLIEMFK NVEELKEELR RTTGMSNMTI NKMLAIPIPD NRAEIISRVF
     WLHSCDANIS NPKLEDAMKE FCNLSLTERS RQSYLIGLTL LHYLDIYNFT YKARVFFPRQ
     NQKPVEKMVE LFIRLKEILN LMASRTTLLL DKMRPLKQMH LPRGVPLTQG IYRGNRMNTP
     QGSFSTISQA LCSQGITTEY LNAMLPSSQR PEGNHTKDFF TYKLSKEQVA LKYGIPLNTT
     PFCFSLYKDI VNMPAGPVIW AFLKPMLLGR ILYAPYTPVT KAIMEKSNVT LRQLAELREK
     SQEWMDKSPF FMNSFHLINQ TIPMLQNTLR NPFVQVFVKF SVGLDAVELL KSIDELDTLR
     IKLENHMDII DHLNTLSSLT VNISSCILYD RIQAANTIEE MEGEAKRLYK TNELFGSVIF
     KLPSNRRWQK GYASENVSLP PVIKYTIRMS LKTAQTTRSL RTKIWAPGPH NSPSHNQIYG
     RAFIYLQDSI ERAIIELQTG SNSQEIAVQV QAIPYPCFMK DNFLTSVSYS LPIVLMVAWV
     VFIAAFVKKL VYEKDLRLHE YMKMMGVNTC SHFFAWFIES VGFLLVTIII LIIILKFGNI
     LPKTNGFILF LYFSDYSFSV IAMSYLISVF FHNTNIAALI GSLIYIIAFF PFIVLITVEN
     ELSYIVKIFM SLLSPTAFSY ASQYIARYEE QGIGLQWDNM YSSPVQDDTT SFGWLCCLIL
     ADSFIYFLIA WYIRNVFPGT YGIAAPWYFP ILPSYWKERF GCSEVKHEKS NGLVFTHIMM
     QNTNPSASPE CMFPSNIEPE PKDLTVGVAL HGVTKIYGSK VAVDNLNLNF YEGHITSLLG
     PNGAGKTTTI SMLTGLFGAS AGTIFVYGKD IKTDLNTVRK NMGVCMQHDV LFSYLTTKEH
     LLLYGSIKVP HWTKKQLHEE VKRTLKDTGL YSHRHKRVGT LSGGMKRKLS ISIALIGGSR
     VVILDEPSTG VDPCSRRSIW DVISKNKTAR TIILSTHHLD EAEVLSDRIA FLEQGGLRCC
     GSPFYLKEAF GDGYHLTITK KKCPNLNANS ICDTMAVTAM IRSHLPEAYL KEIIGGELVY
     VLPPFSTKVS GAYLSLLRAL DNGMSGLNIG CYGISDTTVE EVFLNLTKDS QKNGDMSLEH
     FPQKKIGNSS TNGVSTPDDL SVSSSNFTDR DDKILTRGER LDGFGLFLKK VMAILIKRFH
     HTRRNWKGII AQVILPVVFV TTAMGLGTLR DSGNSYPELQ LSPSLYGTTE QTSFYANFNT
     TTKPLVSAMW AFPGIDNICL NISDLRCLKE GSLGEWNTSG EPSTIFNVCT CSFIFQKCPE
     SNYYPPHRRT YSSQVIYDLS GHPIENYLIS TANEFSQKRY GGWSFGLPLT NDLRFDITGV
     PVNRTLAKVW YDPEGYHSLP AYLNSLNNFL LRVNMSKYDA ARHGIIMYSH PYPGVQDQEQ
     ATISSLIDIL VALSILMGYS VTTASFVTYV VREHQTKAKQ LQHISGIGVT CYWVTNFIYD
     MVFYLVPVAF SIGVIVIFRL PAFYSGNNLG AVSLLLLLFG YATFSWMYLL AGFFHETGIA
     FITYVCVNLF FGINSIVSLS VVYFLSKEKP NDPTLELISE TLKRIFLIFP QFCFGYGLIE
     LSQQQSVLDF LKAYGVEYPS ETFEMNKLGA MFVALVSQGT MFFFLRLLIN EWLIKKFRLF
     FRKFSSSPVM EVVDEDEDVR AERLRVENGA AEFDLVQLHR LTKTYQLIHK KIIAVNNISI
     GIPAGECFGL LGVNGAGKTT IFKMLTGDVI PSSGNILIRN KTGSLGHVDS HSSLVGYCPQ
     EDALDDLVTV EEHLYFYARI HGIPEKDIKE TVHKLLRRLH LMPYKDRATS MCSYGTKRKL
     STALALIGKP SILLLDEPSS GMDPKSKRHL WRIIAEEVQN KCSVILTSHS MEECEALCTR
     LAIMVNGRFQ CIGSLQHIKS RFGRGFTVKV HLKNNEVSME ALTRFMRLHF PKTYLKDQHL
     SMLEYHVPVT AGGVANIFDL LETNKTALNI TNFLVSQTTL EEVFINFAKD QKSYEAADVS
     SDDSTISVDS QDDRIES
//
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