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Database: UniProt
Entry: G3SVU5_LOXAF
LinkDB: G3SVU5_LOXAF
Original site: G3SVU5_LOXAF 
ID   G3SVU5_LOXAF            Unreviewed;      1046 AA.
AC   G3SVU5;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   24-JAN-2024, entry version 78.
DE   RecName: Full=FERM, ARHGEF and pleckstrin domain-containing protein 1 {ECO:0000256|ARBA:ARBA00040395};
DE   AltName: Full=FERM, RhoGEF and pleckstrin domain-containing protein 1 {ECO:0000256|ARBA:ARBA00042170};
GN   Name=FARP1 {ECO:0000313|Ensembl:ENSLAFP00000004389.3};
OS   Loxodonta africana (African elephant).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta.
OX   NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000004389.3, ECO:0000313|Proteomes:UP000007646};
RN   [1] {ECO:0000313|Ensembl:ENSLAFP00000004389.3, ECO:0000313|Proteomes:UP000007646}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000004389.3,
RC   ECO:0000313|Proteomes:UP000007646};
RA   Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., Lindblad-Toh K.;
RT   "The Genome Sequence of Loxodonta africana (African elephant).";
RL   Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSLAFP00000004389.3}
RP   IDENTIFICATION.
RC   STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000004389.3};
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cell projection, dendrite
CC       {ECO:0000256|ARBA:ARBA00004279}. Cell projection, dendritic spine
CC       {ECO:0000256|ARBA:ARBA00004552}. Cell projection, filopodium
CC       {ECO:0000256|ARBA:ARBA00004486}. Cytoplasm, cytosol
CC       {ECO:0000256|ARBA:ARBA00004514}. Synapse, synaptosome
CC       {ECO:0000256|ARBA:ARBA00034102}.
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DR   AlphaFoldDB; G3SVU5; -.
DR   STRING; 9785.ENSLAFP00000004389; -.
DR   Ensembl; ENSLAFT00000005243.3; ENSLAFP00000004389.3; ENSLAFG00000005242.3.
DR   eggNOG; KOG3531; Eukaryota.
DR   GeneTree; ENSGT00940000155318; -.
DR   HOGENOM; CLU_012301_0_0_1; -.
DR   InParanoid; G3SVU5; -.
DR   TreeFam; TF351276; -.
DR   Proteomes; UP000007646; Unassembled WGS sequence.
DR   GO; GO:0005856; C:cytoskeleton; IEA:InterPro.
DR   GO; GO:0008092; F:cytoskeletal protein binding; IEA:InterPro.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:Ensembl.
DR   GO; GO:0007167; P:enzyme-linked receptor protein signaling pathway; IEA:Ensembl.
DR   GO; GO:1904395; P:positive regulation of skeletal muscle acetylcholine-gated channel clustering; IEA:Ensembl.
DR   GO; GO:0016601; P:Rac protein signal transduction; IEA:Ensembl.
DR   CDD; cd14473; FERM_B-lobe; 1.
DR   CDD; cd13193; FERM_C_FARP1-like; 1.
DR   CDD; cd01220; PH1_FARP1-like; 1.
DR   CDD; cd13235; PH2_FARP1-like; 1.
DR   CDD; cd00160; RhoGEF; 1.
DR   Gene3D; 1.20.80.10; -; 1.
DR   Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 3.
DR   InterPro; IPR019749; Band_41_domain.
DR   InterPro; IPR035899; DBL_dom_sf.
DR   InterPro; IPR000219; DH-domain.
DR   InterPro; IPR000798; Ez/rad/moesin-like.
DR   InterPro; IPR014847; FA.
DR   InterPro; IPR041788; FARP1/FARP2/FRMD7_FERM_C.
DR   InterPro; IPR014352; FERM/acyl-CoA-bd_prot_sf.
DR   InterPro; IPR035963; FERM_2.
DR   InterPro; IPR019748; FERM_central.
DR   InterPro; IPR019747; FERM_CS.
DR   InterPro; IPR000299; FERM_domain.
DR   InterPro; IPR018979; FERM_N.
DR   InterPro; IPR018980; FERM_PH-like_C.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR001849; PH_domain.
DR   InterPro; IPR029071; Ubiquitin-like_domsf.
DR   PANTHER; PTHR45858; FERM DOMAIN CONTAINING PROTEIN; 1.
DR   PANTHER; PTHR45858:SF2; FERM, ARHGEF AND PLECKSTRIN DOMAIN-CONTAINING PROTEIN 1; 1.
DR   Pfam; PF08736; FA; 1.
DR   Pfam; PF09380; FERM_C; 1.
DR   Pfam; PF00373; FERM_M; 1.
DR   Pfam; PF09379; FERM_N; 1.
DR   Pfam; PF00169; PH; 2.
DR   Pfam; PF00621; RhoGEF; 1.
DR   PRINTS; PR00935; BAND41.
DR   PRINTS; PR00661; ERMFAMILY.
DR   SMART; SM00295; B41; 1.
DR   SMART; SM01195; FA; 1.
DR   SMART; SM01196; FERM_C; 1.
DR   SMART; SM00233; PH; 2.
DR   SMART; SM00325; RhoGEF; 1.
DR   SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR   SUPFAM; SSF50729; PH domain-like; 3.
DR   SUPFAM; SSF47031; Second domain of FERM; 1.
DR   SUPFAM; SSF54236; Ubiquitin-like; 1.
DR   PROSITE; PS50010; DH_2; 1.
DR   PROSITE; PS00660; FERM_1; 1.
DR   PROSITE; PS50057; FERM_3; 1.
DR   PROSITE; PS50003; PH_DOMAIN; 2.
PE   4: Predicted;
KW   Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW   Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007646};
KW   Synapse {ECO:0000256|ARBA:ARBA00023018};
KW   Synaptosome {ECO:0000256|ARBA:ARBA00022599}.
FT   DOMAIN          40..320
FT                   /note="FERM"
FT                   /evidence="ECO:0000259|PROSITE:PS50057"
FT   DOMAIN          540..731
FT                   /note="DH"
FT                   /evidence="ECO:0000259|PROSITE:PS50010"
FT   DOMAIN          760..857
FT                   /note="PH"
FT                   /evidence="ECO:0000259|PROSITE:PS50003"
FT   DOMAIN          933..1030
FT                   /note="PH"
FT                   /evidence="ECO:0000259|PROSITE:PS50003"
FT   REGION          1..37
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          362..438
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          450..531
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          863..905
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        16..30
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        371..396
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        464..515
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1046 AA;  118880 MW;  D9CB8499C808C0DE CRC64;
     MGEIEQRPTP GSRLGAPENS GISTLEHGQK PPPTPSGKLI SIKIQMLDDT QEAFEVPQRA
     PGKVLLDAVC NHLNLVEGDY FGLEFPDHKK ITVWLDLLKP IVKQIRRPKH VVVKFVVKFF
     PPDHAQLQEE LTRYLFALQV KQDLAQGRLT CNDTSAALLI SHIVQSEIGD FDEALDREHL
     AKNKYIPQQD ALEDKIVEFH HNHIGQTPAE SDFQLLEIAR RLEMYGIRLH PAKDREGTKI
     NLAVANTGIL VFQGFTKINA FNWAKVRKLS FKRKRFLIKL RPDANSSYQD TLEFLMASRD
     FCKSFWKICV EHHAFFRLFE EPKPKPKPVL FSRGSSFRFS GRTQKQVLDY VKEGGHKKVQ
     FERKHSRIHS IRSLASQPAE PNSEVPKQSP QSTGLTYGEG AELPGGQSCQ QGRELKVSAE
     EPGPQQSPSL QKSPLGNKKA DGAIMVTMEE EEEAVKDRSQ QSKPKTSHPQ TGSLTGSPHL
     SELSVNSQGG AAPANVTLSP NLSPDTKQAS PLVSPLLNDQ ACPRTDDEEE VRRKRFPTDK
     AYFIAKEVST TERTYLKDLE VITSWFQSTV SKEDSMPETL KSLIFPNFEP LHKFHTSFLK
     EIEQRLALWE GRSNAHIQGD YQRIGDVMLK NIQGMKPLAV HLWKHNEALE GLENGIKGSR
     RLENFCRDFE LQKVCYLPLN TFLLRPLHRL MHYKQVLERL CKHHPPSHAD FRDCRAALAE
     ITEMVAQLHG TMIKMENFQK LHELKKDLIG VDNLVIPGRE FIRLGSLSKL SGKGLQQRMF
     FLFNDVLLYT SRGLTASNQF KVHGQLPLYG MTIEESEDQW GVPHCLTLRG QRQSIIVAAS
     SRSEMQKWVE DIQMAIDLAE KSSGPTPELL ASSPPDNKSP EEGMAVDQES EDDLSASRTS
     LERQAPHRGN TMVHVCWHRN TSVSMVDFSI AVENQLSGNL LRKFKNSNGW QKLWVVFTNF
     CLFFYKSHQD SHPLASLPLL GYSLTVPSES ENIHKDYVFK LHFKSHVYYF RAESEYTFDR
     WMEVIRSATS SASRTHILSH KESHVY
//
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