GenomeNet

Database: UniProt
Entry: G3SWM7_LOXAF
LinkDB: G3SWM7_LOXAF
Original site: G3SWM7_LOXAF 
ID   G3SWM7_LOXAF            Unreviewed;      4449 AA.
AC   G3SWM7;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   30-AUG-2017, entry version 38.
DE   SubName: Full=Ryanodine receptor 3 {ECO:0000313|Ensembl:ENSLAFP00000004741};
GN   Name=RYR3 {ECO:0000313|Ensembl:ENSLAFP00000004741};
OS   Loxodonta africana (African elephant).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta.
OX   NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000004741, ECO:0000313|Proteomes:UP000007646};
RN   [1] {ECO:0000313|Ensembl:ENSLAFP00000004741}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000004741};
RA   Di Palma F., Heiman D., Young S., Johnson J., Lander E.S.,
RA   Lindblad-Toh K.;
RT   "The Genome Sequence of Loxodonta africana (African elephant).";
RL   Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSLAFP00000004741}
RP   IDENTIFICATION.
RC   STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000004741};
RG   Ensembl;
RL   Submitted (SEP-2011) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00448}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSLAFP00000004741}.
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DR   Ensembl; ENSLAFT00000005649; ENSLAFP00000004741; ENSLAFG00000005626.
DR   eggNOG; KOG2243; Eukaryota.
DR   eggNOG; ENOG410YCNW; LUCA.
DR   GeneTree; ENSGT00760000119152; -.
DR   Proteomes; UP000007646; Unassembled WGS sequence.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF100909; SSF100909; 2.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF49899; SSF49899; 3.
DR   PROSITE; PS50188; B302_SPRY; 3.
DR   PROSITE; PS50222; EF_HAND_2; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000007646};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007646};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   3762   3786       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   3990   4010       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4058   4077       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4189   4207       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4250   4271       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4330   4353       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      163    374       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN      590    786       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN      832   1044       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     3498   3533       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   COILED     3912   3939       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   4449 AA;  505492 MW;  11F65BEE14A6F01E CRC64;
     SGNNRTAAPV TLPIEEVLQT LQDLIAYFQP PEEEMRHEDK QNKLRSLKNR QNLFKEEGML
     ALVLNCIDRL NIYNSVAHFA GIAREESGTA WKEILNLLYK LLAALIRGNR NNCAQFSNNL
     DWLISKLDRL ESSSGILEVL HCILIESPEA LNLIAEGHIK SIISLLDKHG RNHKVLDVLC
     SLCLCNGVAV RANQNLICDN LLPRRNLLLQ TRLINDVTSI RPNIFLGVAE GSAQYKKWYF
     ELIIDQVDPF LTAEPTHLRV GWASSSGYAP YPGGGEGWGG NGVGDDLYSY GFDGLHLWSG
     RIPRAVASIN QHLLRSDDVV SCCLDLGVPS ISFRINGQPV QGMFENFNTD GLFFPVVSFS
     AGVKVRFLMG GRHGEFKFLP PSGYAPCYEA LLPKEKMRLE PVKEYKRDAE GVRDLLGTTQ
     FLSQASFIPC PIDTSQVVLP PHLEKIRDRL AENIHELWGM NKIELGWTFG KTRDDNKRQH
     PCLVEFSKLP ETEKNYNLQM STETLKTLLA LGCHIAHANP AAEEDLKKVK LPKNYMMSNG
     YKPAPLDLSD VKLSPPQEIL VDKLAENAHN VWAKDRLKQG WTYGIQQDLK NKRNPRLVPY
     ALLDERTKKS NRDSLREAVR TFVGYGYNIE PSDQELADPT VEKVSIDKIR FFRVERSYAV
     RSGKWYFEFE VVTGGDMRVG WARPGCRPDI ELGADDQAFV FEGSRGQRWH QGSGYFGRTW
     QPGDVVGCMI NLDDASMIFT LNGELLITNK GSELAFADYE VENGFVPICS LGLSQIGRMN
     LGTDASTFKY YTMCGLQEGF EPFAVNMNRD VAMWFSKRLP TFVNVPKDHP HIEVMRIDGT
     MDSPPCLKVS HKTFGTQNSS AGMIYCRLSM PVECHSSFSH IPCLDSDAFQ KRKQMQEIFS
     HPTTQCYYAI RIFAGQDPTC VWVGWVTPDY HLYSEKFDLN KNCTVTVTLG DERGRVHESV
     KRSNCYMVWG GDIVASSQRS SRSNVDLEIG CLVDLAMGML SFSANGKELG TCYQVEPNTK
     VFPAVFLQPT STSLFQFELG KLKNAMPLSA AIFKSEEKNP VPQCPPRLDV QTIQPVLWSR
     MPSNFLKVEM ERVSERHGWV VQCLEPLQMM ALYIPEENRC VDILELCEQE DLMQFHYHTL
     RLYSAVCALG NNRVAYALCS HVDLSQLFYA IDNKYLPGLL RSGFYDLLIS IHLANAKERK
     LMMKNEYIIP ITSTTRKVSL YPDESKRHGL PGVGLRTCLK PGFRFSTPCF VVTSEEHHKQ
     SPEIPLEILK TKALSMLTEA VQCSGAHIRD PVGGSVEFQF VPVLKLIGSL LVMGVFNDED
     VQQILLLIDP SVFGEHSGET EEGGEKEEVT QVEEKAVEAG EKASKEAQAP VKGLLQTRIP
     ESVKLQMCEL LSYLCDCELQ HRVEAIVAFG DIYVSKLQAN QKFRYNELMQ ALNMSAALTA
     RKTKEFRSPP QEQINMLVNF QLGENCPCPE EIREELYDFH EDLLLHCGVP LEEEEEEEDN
     TSWTGKLWSL VYKIKGLPKP EKQQPTEEEE GAPTTLKELI SQTMICWAQE DQVQDAELVR
     MMFTLLRRQY DSIGELLQAL RKTYTISHAS VSDTINLLAA LGQIRSLLSV RMGKEEELLM
     IHGLGDIMNN KVFYQHPNLM RVLGMHETVM EVMVNVLGTE KSQIAFPKMV ASCCRFLCYF
     CRISRQNQKA MFEHLSYLLE NSSFGLASPS MRGSTPLDVA ASSVMDNNEL ALSLEEPDLE
     KVVTYLAGCG LQSCPMLLAK GYPDIGWNPI EGERYLSFLR FAVFVNSESV EENASVVVKL
     LIRRPECFGP ALRGEGGNGL LAAMQGAIKI SENPALDLPS QGYKREVMED DGEGEEIVHM
     GNAIMSFYSA LIDLLGRCAP EMHLIQTGKG EAIRIRSILR SLVPTEDLVG IISIPLKLPS
     VNKDGSVMEP DMAANFCPDH KAPMVLFMDR VYGIKDQPFL LHLLEVGFLP DLRASASLDT
     VSLSTTEAAL ALNRYICSAV LPLLTRCAPL FAGTEHCTSL IDSTLQTIYR LSKGRSLTKA
     QRDTIEECLL AICNHLRPSM LQQLLRRLVF DVPLLNEYCK MPLKLLTNHY EQCWKYYCLP
     SGWGSYGLAV EEELHLTEKL FWGIFDSLSH KKYDPDLFRM ALPCLSAIAG ALPPDYLDTR
     ITATLEKQVS VDAEGNFDPK PINTMNFSLP EKLEYVVTKY AEHSHDKWAC DKSQNGWKYG
     ISLDENVKTH PLIRPFRTLT EKEKEIYRWP ARESLKTMLA VGWTVERTKE GEALVQQREN
     EKLRSMSQAS QGNSYSPAPL DLSNVVLSRE LQGMVEVVAE NYHNIWAKKK KLELESKGGG
     SHPLLVPYDT LTAKEKFRDR EKAQDLFKFL QVNGIIVSRG MKDMELDASS MEKRFAHKFL
     KKILKYVDSA QEFIAHLEAI VSSGKTEKSP HDQEIKFFAK VLLPLVDQYF TNHRLYFLSS
     PLKPLSSSGY ASHKEKEMVA SLFCKLAALV RHRISLFGND STTMVSCLHI LAQTLDTRTV
     MKSGSELVKA GLRAFFENAA EDLEKTSENL KLGKFTHSRT QIKGVSQNIN YTTVALLPIL
     TSIFEHVAQH QFGMDLLLGD VQISCYHTLC SLYSLGTGKN IYVERQRPAL GECLASLAAT
     IPVAFLEPTL NRNNPLSVFN TKTPRERSIL GMPDTVEEMC PDIPHLEGLM KEINDLAESG
     ARYTEMPHVI EVILPMLCNY LSYWWERGPE NLPPSAGPCC TQVTSEHLSV ILGNILKIIN
     NNLGIDEASW MKRIAVYAQP IISKARPDLL RSHFIPTLEK LKKKAVKIVQ EEEQLKADSR
     GDTQEAELLI LDEFAVLCRD LYAFYPMLIR YVDNNRSNWL KSPGADSDQL FRMVAEVFIL
     WCKSHNFKRE EQNFVIQNEI NNLAFLTGDS KSKMSKVRME VGSGGQDQER KKTKRRGDFY
     SIQTSLIVAA LKKMLPIGLN MCTPGDQELI SLAKSRYSYR DTDEEVKEHL RNNLHLQEKS
     DDPAVKWQLN LYKDVLKSEE PSNPEKTVER VQRISAAVFH LEQVEQPLRS KKAVWHKLLS
     KQRKRAVVAC FRMAPLYNLP RHRSINLFLH GYQRFWIETE EYSFEEKLVQ DLAKSPKAEE
     EEEEEMEKPP DPLHQIILHF SRNALTERSK LEDDPLYTSY SSMMAKSCQN GEDEEEEDKE
     KTFEEKEMEK QKTLYQQARL HERGAAEMVL QMISASKGEM SPMVVETLKL GIAILNGGNT
     SVQQKMLDYL KEKKDAGFFQ SLSGLMQSCS VLDLNAFERQ NKAEGLGMVT EEGTLIVRER
     GEKVLQNDEF TRDLFRFLQL LCEGHNSDFQ NFLRTQMGNT TTVNIIISTV DYLLRLQESI
     SDFYWYYSGK DIIDESGQHN FSKALAVTKQ IFNSLTEYIQ GPCIGNQQSL AHSRLWDAVV
     GFLHVFANMQ MKLSQDSSQI ELLKELLDLL QDMVVMLLSL LEGNVVNGTI GKQMVDTLVE
     SSTNVEMILK FFDMFLKLKD LTSSETFKEY DPDGKGIISK KEFQKAMEGQ KQYTQSEIDF
     LLSCAEADEN DMFNYIDFVD RFHEPAKDIG FNVAVLLTNL SEHMPNDSRL KCLLDPAESV
     LNYFEPYLGR IEIMGGAKKI ERVYFEISES SRTQWEKPQV KESKRQFIFD VVNEGGEQEK
     MELFVNFCED TIFEMQLASQ ISESDSADRP EEVEEEEDSL YTLEMEGDEE EDTSFETASA
     FAMACASVKR NIANFLKRAT LKNLKKQYRK VKKMTAKELV KVFFSFFWML FVGLFQLFFT
     ILGGVFQILW NTVFGGGLVE GAKNIRVTKI LGDMPDPTQF GIHDDVIEAE RAEVIEPGIT
     TELVHFIKGE KGDADIMSDL FGLHPKKEGS LKHGPDGGLG DLSEIIGKDG PPTLESTVQK
     KRKAQAAERK VVREAEGKVD SEKADMEDGE KEERAKEEEQ AEYLWAEVTK KKKRRRGQKV
     EKPEAFMANF FKRLEIYQTK LLHYLARNFY NLRFLALFVA FAINFILLFY KVTEEPLEEE
     TEDVANLWNS FNDEEEEEAM VFFVLQESTG YMAPTLRALA IIHTIISLVC VVGYYCLKVP
     LVVFKREKEI ARKLEFDGLY ITEQPSEDDI KGQWDRLVIN TPSFPSNYWD KFVKRKVINK
     YGDLYGAERI AELLGLDKNA LDFSPVEEAK TEEASLVSWL SSVDMKYHIW KLGVVFTDNS
     FLYLAWYTTM SFLGHYNNFF FAAHLLDIAM GFKTLRTILS SVTHNGKQLV LTVGLLAVVV
     YLYTVVAFNF FRKFYNKSED DDEPDMKCDD MMTCYLFHMY VGVRAGGGIG DEIEDPAGDP
     YEMYRIVFDI TFFFFVIVIL LAIIQGLIID AFGELRDQQE QVREDMETKC FICGIGNDYF
     DTTPHGFETH TLQEHNLANY LFFLMYLINK DETEHTGQES YVWKMYQERC WDFFPAGDCF
     RKQYEDQLG
//
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