ID G3SXA6_LOXAF Unreviewed; 4490 AA.
AC G3SXA6;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 80.
DE SubName: Full=LDL receptor related protein 1 {ECO:0000313|Ensembl:ENSLAFP00000005024.3};
GN Name=LRP1 {ECO:0000313|Ensembl:ENSLAFP00000005024.3};
OS Loxodonta africana (African elephant).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta.
OX NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000005024.3, ECO:0000313|Proteomes:UP000007646};
RN [1] {ECO:0000313|Ensembl:ENSLAFP00000005024.3, ECO:0000313|Proteomes:UP000007646}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000005024.3,
RC ECO:0000313|Proteomes:UP000007646};
RA Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Loxodonta africana (African elephant).";
RL Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLAFP00000005024.3}
RP IDENTIFICATION.
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000005024.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the LDLR family.
CC {ECO:0000256|ARBA:ARBA00009939}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR STRING; 9785.ENSLAFP00000005024; -.
DR Ensembl; ENSLAFT00000005991.3; ENSLAFP00000005024.3; ENSLAFG00000005976.3.
DR eggNOG; KOG1215; Eukaryota.
DR GeneTree; ENSGT00940000157899; -.
DR HOGENOM; CLU_000085_2_1_1; -.
DR InParanoid; G3SXA6; -.
DR OMA; TEQLYWI; -.
DR TreeFam; TF315253; -.
DR Proteomes; UP000007646; Unassembled WGS sequence.
DR GO; GO:0016323; C:basolateral plasma membrane; IEA:Ensembl.
DR GO; GO:0005769; C:early endosome; IEA:Ensembl.
DR GO; GO:0043235; C:receptor complex; IEA:Ensembl.
DR GO; GO:0016964; F:alpha-2 macroglobulin receptor activity; IEA:Ensembl.
DR GO; GO:0034185; F:apolipoprotein binding; IEA:Ensembl.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0032050; F:clathrin heavy chain binding; IEA:Ensembl.
DR GO; GO:0044877; F:protein-containing complex binding; IEA:Ensembl.
DR GO; GO:0150094; P:amyloid-beta clearance by cellular catabolic process; IEA:Ensembl.
DR GO; GO:0150093; P:amyloid-beta clearance by transcytosis; IEA:Ensembl.
DR GO; GO:0006909; P:phagocytosis; IEA:Ensembl.
DR GO; GO:0045807; P:positive regulation of endocytosis; IEA:Ensembl.
DR GO; GO:1905167; P:positive regulation of lysosomal protein catabolic process; IEA:Ensembl.
DR GO; GO:1903078; P:positive regulation of protein localization to plasma membrane; IEA:Ensembl.
DR GO; GO:0006898; P:receptor-mediated endocytosis; IEA:Ensembl.
DR CDD; cd00054; EGF_CA; 1.
DR CDD; cd00112; LDLa; 30.
DR Gene3D; 4.10.1220.10; EGF-type module; 1.
DR Gene3D; 2.10.25.10; Laminin; 13.
DR Gene3D; 4.10.400.10; Low-density Lipoprotein Receptor; 29.
DR Gene3D; 2.120.10.30; TolB, C-terminal domain; 8.
DR InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR InterPro; IPR026823; cEGF.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR036055; LDL_receptor-like_sf.
DR InterPro; IPR023415; LDLR_class-A_CS.
DR InterPro; IPR000033; LDLR_classB_rpt.
DR InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR InterPro; IPR032485; LRP1-like_beta_prop.
DR PANTHER; PTHR22722:SF5; LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 1B; 1.
DR PANTHER; PTHR22722; LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 2-RELATED; 1.
DR Pfam; PF12662; cEGF; 1.
DR Pfam; PF16472; DUF5050; 1.
DR Pfam; PF07645; EGF_CA; 2.
DR Pfam; PF14670; FXa_inhibition; 3.
DR Pfam; PF00057; Ldl_recept_a; 28.
DR Pfam; PF00058; Ldl_recept_b; 10.
DR PRINTS; PR00261; LDLRECEPTOR.
DR SMART; SM00181; EGF; 25.
DR SMART; SM00179; EGF_CA; 7.
DR SMART; SM00192; LDLa; 30.
DR SMART; SM00135; LY; 35.
DR SUPFAM; SSF57196; EGF/Laminin; 4.
DR SUPFAM; SSF57184; Growth factor receptor domain; 4.
DR SUPFAM; SSF57424; LDL receptor-like module; 29.
DR SUPFAM; SSF63825; YWTD domain; 8.
DR PROSITE; PS00010; ASX_HYDROXYL; 1.
DR PROSITE; PS00022; EGF_1; 3.
DR PROSITE; PS01186; EGF_2; 4.
DR PROSITE; PS50026; EGF_3; 6.
DR PROSITE; PS01187; EGF_CA; 2.
DR PROSITE; PS01209; LDLRA_1; 15.
DR PROSITE; PS50068; LDLRA_2; 30.
DR PROSITE; PS51120; LDLRB; 25.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Endocytosis {ECO:0000256|ARBA:ARBA00022583};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000007646};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 4370..4390
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REPEAT 282..325
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 326..369
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 518..560
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 561..606
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 607..657
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 658..701
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 1256..1302
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 1303..1345
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 1346..1392
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 1393..1437
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 1573..1615
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 1616..1659
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 1660..1699
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 1880..1922
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 1923..1965
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 1966..2009
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 2010..2053
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 2290..2334
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 2335..2377
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT DOMAIN 2928..2963
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT REPEAT 3015..3059
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 3060..3102
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 3103..3146
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 3147..3189
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 3916..3958
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 3959..4002
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT DOMAIN 4142..4175
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 4178..4214
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 4215..4247
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 4250..4286
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 4321..4355
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT REGION 1852..1873
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 801..813
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 808..826
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 842..854
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 849..867
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 883..895
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 890..908
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 931..949
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 943..958
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 962..974
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 969..987
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1029..1044
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1072..1087
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2478..2496
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2512..2524
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2519..2537
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2531..2546
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2551..2563
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2558..2576
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2570..2585
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2619..2634
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2642..2654
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2649..2667
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2661..2676
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2680..2692
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2687..2705
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2764..2776
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2771..2789
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2804..2816
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2858..2876
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2870..2885
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2932..2942
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 3280..3292
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3287..3305
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3320..3332
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3327..3345
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3339..3354
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3379..3394
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3482..3494
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3489..3507
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3501..3516
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3521..3533
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3528..3546
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3540..3555
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3559..3571
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3566..3584
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3578..3593
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3600..3612
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3607..3625
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3662..3677
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3695..3713
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3707..3722
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 4146..4156
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 4182..4192
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 4204..4213
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 4218..4228
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 4254..4264
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 4276..4285
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 4323..4333
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 4345..4354
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 4490 AA; 498902 MW; A6BA0A88FECCEEB4 CRC64;
PDGSDEAPEI CPQSKVQRCQ PNEHNCLGTE LCVSMSRLCN GVQDCMDGSD EGSHCRELQG
NCSRLGCQHH CVPTLAGPTC YCNSSFQLQA DGKTCKDFDE CSVYGTCSQL CTNTDGSFTC
GCVEGYLLQP DNRSCKAKNE PVDRPPVLLI ANSQNILATY LSGAQVSTIT PTSTRQTTAM
DFSYANETVC WVHVGDSAAQ TQLKCARMPG LKGFVDEHTI NISLSLHHVE QMAIDWLTGN
FYFVDDIDDR IFVCNRNGDT CVTLLDLELY NPKGIALDPA MGKVFFTDYG QIPKVERCDM
DGQNRTKLVD SKIVFPHGIT LDLVSRLVYW ADAYLDYIEV VDYEGKGRQT IIQGILIEHL
YGLTVFENYL YATNSDNANA QQKTSVIRVN RFNSTEYQVV TRVDKGGALH IYHQRRQPRV
RSHACENDQY GKPGGCSDIC LLANSHKART CRCRSGFSLG SDGKSCKKPE HELFLVYGKG
RPGIIRGMDM GAKVPDEHMI PIENLMNPRA LDFHAETGFI YFADTTSYLI GRQKIDGTER
ETILKDGIHN VEGVAVDWMG DNLYWTDDGP KKTISVARLE KAAQTRKTLI EGKMTHPRAI
VVDPLNGWMY WTDWEEDPKD SRRGRLERAW MDGSHRDVFV TSKTVLWPNG LSLDIPAGRL
YWVDAFYDRI ETILLNGTDR KIVYEGPELN HAFGLCHHGN YLFWTEYRSG SVYRLERGTG
GSPPTVTLLR SERPPIFEIR MYDAQQQQVG TNKCRVNNGG CSSLCLATPG SRQCACAEDQ
VLDADGVTCL ANPSYVPPPQ CQPGEFACAN SRCIQERWKC DGDNDCLDNS DEAPALCHQH
TCPSDRFKCE NNRCIPNRWL CDGDNDCGNS EDESNATCSA RTCPPNQFSC ASGRCIPISW
TCDLDDDCGD RSDESASCAY PTCFPLTQFT CNNGRCININ WRCDNDNDCG DNSDEAGCSH
SCSSTQFKCN SGRCIPEHWT CDGDNDCGDY SDETHANCTN QATRPPGGCH TDEFQCRLDG
LCIPLRWRCD GDTDCMDSSD EKSCEGVTHV CDPNVKFGCK DSARCISKAW VCDGDSDCED
NSDEENCESL ACRPPSHPCA NNTSVCLPPD KLCDGNDDCG DSSDEGELCD QCSLNNGGCS
HNCSVAPGEG IVCSCPLGME LGPDNHTCQI QSYCAKHLKC SQKCDQNKFS VKCSCYEGWV
LEPDGESCRS LDPFKPFIIF SNRHEIRRID LHKGDYSVLV PGLRNTIALD FHLSQSALYW
TDVVEDKIYR GKLLDNGALT SFEVVIQYGL ATPEGLAVDW IAGNIYWVES NLDQIEVAKL
DGTLRTTLLA GDIEHPRAIA LDPRDGILFW TDWDASLPRI EAASMSGAGR RTIHRETGSG
GWPNGLTVDY LEKRILWIDA RSDAIYSARY DGSGHMEVLR GHEFLSHPFA VTLYGGEVYW
TDWRTNTLAK ANKWTGHNVT VVQRTNTQPF DLQVYHPSRQ PMAPNPCEAN GGRGPCSHLC
LINYNRTVSC ACPHLMKLHK DTTTCYEFKE CLLYARQMEI RGVELDPYYN YILSFTPDID
KCHCDWTPMP AEQRVYLSDV RTQAIKRAFI NGTGVETVVS ADLPNAHGLA VDWVSRNLFW
TSYDTNKKQI NVARLDGSFK NAVVQGLEQP HSLVVHPLRG KLYWTDGDNI SMANMDGSNR
TLLFSGQKGP VGLAIDFPES KLYWISSRNH TINRCNLDGS GLEVIEAMRS QLGKATALAI
MGDKLWWADQ VSEKMGTCNK ADGSGSVVLR NSTTLVMHMK VYDESPQLDH EGTNPCSINN
GDCSQLCLPT SETTRSCMCT AGYSLRSGQQ ACEGQKPPLC WVLWGRGGTL PQPPSSAPSP
LLSTVNPQHS VSASPPLEND TIYWVDMGLS TISRAKRDQT WREDVVTNGI GRVEGIAVDW
IAGNIYWTDQ GFDVIEVARL NGSFRYVVIS QGLDKPRAIT VHPEKGYLFW TEWGQYPRIE
RSRLDGTERV VLVNVSISWP NGISVDYEDG KLYWCDARTD KIERIDLETG ENREVVLSSN
NMDMFSVSVF EEFIYWSDRT HANGSIKRGS KDNATDSVPL RTGIGVQLKD IKVFNRDRQK
GTNVCAVTNG GCQQLCLYRG GGQRACACAH GMLAEDGASC REYAGYLLYS ERTILKSIHL
SDERNLNAPV QPFEDPEHMK NVIALAFDYR AGTSPGTPNR IFFSDIHFGN IQQINDDGSG
RTTIVENVGS VEGLAYHRGW DTLYWTSYTT STITRHTVDQ TRPGAFERET VITMSGDDHP
RAFVLDECQN LMFWTNWNEQ HPSIMRAALS GANVLTLIEK DIRTPNGLAI DHRAEKLYFS
DATLDKIERC EYDGSHRYVI LKSEPVHPFG LAVYGEHIFW TDWVRRAVQR ANKFVGSDMK
LLRVDIPQQP MGIIAVANDT NSCELSPCRV NNGGCQDLCL LTHQGHVNCS CRGGRILQED
FTCRAVNSSC RAQDEFECAS GECINFSLTC DGVSHCKDKS DEKPSYCNSR RCKKTFRQCS
NGRCVSNMLW CNGADDCGDG SDEIPCNKTA CSVGEFRCRD GTCIGNSSRC NQFVDCEDAS
DEMNCSATDC SSYFRLGVKG VLFQPCERTS LCYAPSWVCD GANDCGDYSD ERDCPGMKRP
RCPLNYFACP SGRCIPMSWT CDKEDDCEHG EDETHCNKFC SETQFECQNH RCISKQWLCD
GSDDCGDGSD EAAHCEGKTC GPSSFSCPGT HVCVPERWLC DGDKDCADGA DESVAAGCLY
NSTCDGREFM CQNRQCIPKH FVCDHDRDCA DGSDESPECE YPTCGPNEFR CANGRCLSSR
QWECDGENDC HDQSDEAPKN PHCTSSEHKC NASSQFLCSS GRCVAEVLLC NRQDDCGDGS
DERGCHINEC LSRKLSGCSQ DCEDLKIGFK CRCRPGFRLK DDGRTCADVD ECSTTFPCSQ
RCINTHGSYK CLCVEGYAPR GGHPHSCKAV TDEEPFLIFA NRYYLRRLNL DGSNYTLLKQ
GLNNAVALDF DYREQMIYWT DVTTQGSMIR RMHLNGSSVQ VLHRTGLSNP DGLAVDWVGG
NLYWCDKGRD TIEVSKLNGA YRTVLVSSGL SEPRALVVDV QNGYLYWTDW GDHSLIGRIG
MDGSGRSVIV DTKITWPNGL TLDYVTERIY WADAREDYIE FASLDGSNRH VVLSQDIPHI
FALTLFEDYV YWTDWETKSI NRAHKTTGAN KTLLISTLHR PMDLHVFHAL RQPDVPNHPC
KVNNGGCSNL CLLSPRGGHK CACPTNFYLG SDGRTCVSNC TASQFVCKND KCIPFWWKCD
TEDDCGDHSD EPPDCPEFKC RPGQFQCSTG ICTNPAFICD GDNDCQDNSD EANCDIHVCL
PSQFKCTNTN RCIPGIFRCN GQDNCGDGED ERDCPEVTCA PNQFQCSITK RCIPRVWVCD
RDNDCVDGSD EPANCTQMTC GVDEFRCKDS GRCIPARWKC DGEDDCGDGS DEPKEECDER
TCEPYQFRCK NNRCVPGRWQ CDYDNDCGDN SDEESCTPRP CSESEFSCAN GRCIAGRWKC
DGDHDCADGS DEKDCTPRCD MDQFQCKSGH CIPLRWRCDA DADCMDGSDE EACGTGVRTC
PLDEFQCNNT LCKPLAWKCD GEDDCGDNSD ENPEECAQFL CPPNRPFRCK NNRVCLWIGR
QCDGTDHCGD GTDEEDCEPP TAQMPHCKDK KEFLCRNQRC LSSSLRCNMF DDCGDGSDEE
GCSIDPKLTS CAANTSICGD EARCVRTEKA AYCACRPGFH TVPGQPGCQD INECLRFGTC
SQLCNNTKGS HLCSCARNFM KTHNTCKAEG SEYQVLYIAD DNEIRSLFPG HPHSAYEQAF
QGDESVRIDA MDVHVKAGRV YWTNWHTGTI SYRSLPPAAP PTTSNRHRRQ IDRGVTHLNI
SGLKMPRGIA IDWVAGNVYW TDSGRDVIEV AQMKGENRKT LISGMIDEPH AIVVDPLRGT
MYWSDWGNHP KIETAAMDGT LRETLVQDNI QWPTGLAVDY HNERLYWADA KLSIIGSIRL
NGTDPVVAAD SKRGLSHPFS IDVFEDYIYG VTYINNRVFK IHKFGHSPLV NLTGALSHAS
DVVLYHQHKQ PEVTNPCDRK KCEWLCLLSP SGPVCTCPNG KRLDNGTCVA VPSPTPPPDA
PRPGTCNLQC FNGGSCFLNA RRQPKCRCQP RYTGDKCELD QCWEYCRNGG TCAASPSGMP
TCRCPTGFTG PKCTQQVCAG YCANNSTCSV NQGNQPQCRC LPGFLGDRCQ YRHCSGYCEN
FGTCQMAADG SRQCRCTAYF EGPRCEVNKC SRCLEGTCVV NKQSGDVTCN CSDGRVAPSC
LTCVGHCSNG GSCTMNSKMM PECQCPPHMT GPRCEEQVVS QEQPGHMASI LIPLLLLLLL
LLVAGVVFWY KRHVRGAKGF QHQRMTNGAM NVEIGNPTYK MYEGGEPDDV GGLLDADFAL
DPDKPTNFTN PVYATLYMGG HGSRHSLAST DEKRELLGRG PEDEIGDPLA
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