ID G3SY06_LOXAF Unreviewed; 949 AA.
AC G3SY06;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 72.
DE RecName: Full=Guanylate cyclase {ECO:0000256|RuleBase:RU003431};
DE EC=4.6.1.2 {ECO:0000256|RuleBase:RU003431};
GN Name=GUCY2D {ECO:0000313|Ensembl:ENSLAFP00000005331.3};
OS Loxodonta africana (African elephant).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta.
OX NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000005331.3, ECO:0000313|Proteomes:UP000007646};
RN [1] {ECO:0000313|Ensembl:ENSLAFP00000005331.3, ECO:0000313|Proteomes:UP000007646}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000005331.3,
RC ECO:0000313|Proteomes:UP000007646};
RA Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Loxodonta africana (African elephant).";
RL Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLAFP00000005331.3}
RP IDENTIFICATION.
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000005331.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=GTP = 3',5'-cyclic GMP + diphosphate; Xref=Rhea:RHEA:13665,
CC ChEBI:CHEBI:33019, ChEBI:CHEBI:37565, ChEBI:CHEBI:57746; EC=4.6.1.2;
CC Evidence={ECO:0000256|RuleBase:RU003431};
CC -!- SUBCELLULAR LOCATION: Photoreceptor outer segment membrane
CC {ECO:0000256|ARBA:ARBA00004451}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004451}.
CC -!- SIMILARITY: Belongs to the adenylyl cyclase class-4/guanylyl cyclase
CC family. {ECO:0000256|RuleBase:RU000405}.
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DR AlphaFoldDB; G3SY06; -.
DR STRING; 9785.ENSLAFP00000005331; -.
DR Ensembl; ENSLAFT00000006347.3; ENSLAFP00000005331.3; ENSLAFG00000006345.3.
DR eggNOG; KOG1023; Eukaryota.
DR GeneTree; ENSGT00940000161326; -.
DR HOGENOM; CLU_001072_1_0_1; -.
DR InParanoid; G3SY06; -.
DR OMA; LPFDTIH; -.
DR TreeFam; TF106338; -.
DR Proteomes; UP000007646; Unassembled WGS sequence.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:Ensembl.
DR GO; GO:0042622; C:photoreceptor outer segment membrane; IEA:Ensembl.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0004383; F:guanylate cyclase activity; IEA:UniProtKB-EC.
DR GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0007601; P:visual perception; IEA:UniProtKB-KW.
DR CDD; cd07302; CHD; 1.
DR CDD; cd14043; PK_GC-2D; 1.
DR Gene3D; 3.40.50.2300; -; 1.
DR Gene3D; 3.30.70.1230; Nucleotide cyclase; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR001054; A/G_cyclase.
DR InterPro; IPR018297; A/G_cyclase_CS.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR011645; HNOB_dom_associated.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR029787; Nucleotide_cyclase.
DR InterPro; IPR028082; Peripla_BP_I.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR PANTHER; PTHR11920; GUANYLYL CYCLASE; 1.
DR PANTHER; PTHR11920:SF228; RETINAL GUANYLYL CYCLASE 1; 1.
DR Pfam; PF01094; ANF_receptor; 1.
DR Pfam; PF00211; Guanylate_cyc; 1.
DR Pfam; PF07701; HNOBA; 1.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR SMART; SM00044; CYCc; 1.
DR SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS00452; GUANYLATE_CYCLASE_1; 1.
DR PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PE 3: Inferred from homology;
KW cGMP biosynthesis {ECO:0000256|ARBA:ARBA00023293,
KW ECO:0000256|RuleBase:RU003431}; Coiled coil {ECO:0000256|SAM:Coils};
KW Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000256|RuleBase:RU000405};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000007646};
KW Sensory transduction {ECO:0000256|ARBA:ARBA00022606};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Vision {ECO:0000256|ARBA:ARBA00023305}.
FT TRANSMEM 311..333
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 314..651
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT DOMAIN 723..853
FT /note="Guanylate cyclase"
FT /evidence="ECO:0000259|PROSITE:PS50125"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 909..949
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 660..687
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 949 AA; 103776 MW; 7FC79368BC4985A9 CRC64;
PRQLCAGTTA PAGTPPQTPS TPSCGTFRWA RVALVTAPQD LWVEAGRALA AALRARGLPV
ALVTSMEPSD LAGAREALRR VRDGPRVRAV IMVMHSVLLG GEEQRRLLEA AEELGLADGS
LVFLPFDTLH YALSPGPEAL AALANSSQLR RAHDAVLTLT RHCPPESSVL DSLRRAQEIK
ELPPDLNPQQ VSPLFGTIYD SVSLLARGVA GARAAGGGGW VSGAAVARYA RDAQVPGFCG
TLGGVEPGFV LLDTDAAGDQ LFATHTLDPA QGSRSPGTRC TFPRGGRGPG PNPWCWFDPE
DICNGGVEPG LVFLGFLLVV GMGLTGAFLA HYLRHRLLHS QMASGPNKII LTLDDISFLH
PQRSSSRKVV RGSRSSLAAH SVADIRSQPP DSSNIGLYEG DWVWLKKFPG DQHIAIRPAT
KTAFSKLREL RHENVALYLG LFLARGADGA VARGEGILAV VSEHCTRGSL HDLLAQRDIK
LDWMFKSSLL LDLIKGVRYL HHRGVAHGRL KSRNCVVDGR FVLKVTDHGH GRLLEAQRVL
PEPPSAEDQL WTAPELLRDP ALERRGTLAG DVFSLGIIMQ EVVCRSVPYA MLELTAKEVV
QRVQSPPPLC RPLVSMDQAP MECIQLMEQC WAEQPDLRPS TDRTFDLFKS INKGRKMNII
DSMLRMLEQY SSNLEDLIRE RTEELELEKQ KTDRLLTQML PPSVAEALKM GTPVEPEYFE
EVTLYFSDIV GFTTISAMSE PIEVVDLLND LYTLFDAIIG AHDVYKVETI GDAYMVASGL
PQRNGQRHAA EIANMALDIL SAVGSFRMRH MPEVPVRIRI GLHSGPCVAG VVGLTMPRYC
LFGDTVNTAS RMESTGLPYR IHVNMSTVRI LRALDEGFQV EVRGRTEAEG GKGVEDTYWL
VGRRGFSKPI PKPPDLQPGA SNHGISLQEI PPERRQKLEK ARPGQFLGK
//
