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Database: UniProt
Entry: G3SYE9_LOXAF
LinkDB: G3SYE9_LOXAF
Original site: G3SYE9_LOXAF 
ID   G3SYE9_LOXAF            Unreviewed;      4951 AA.
AC   G3SYE9;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   30-AUG-2017, entry version 43.
DE   SubName: Full=Ryanodine receptor 2 {ECO:0000313|Ensembl:ENSLAFP00000005517};
GN   Name=RYR2 {ECO:0000313|Ensembl:ENSLAFP00000005517};
OS   Loxodonta africana (African elephant).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta.
OX   NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000005517, ECO:0000313|Proteomes:UP000007646};
RN   [1] {ECO:0000313|Ensembl:ENSLAFP00000005517}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000005517};
RA   Di Palma F., Heiman D., Young S., Johnson J., Lander E.S.,
RA   Lindblad-Toh K.;
RT   "The Genome Sequence of Loxodonta africana (African elephant).";
RL   Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSLAFP00000005517}
RP   IDENTIFICATION.
RC   STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000005517};
RG   Ensembl;
RL   Submitted (SEP-2011) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00448}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSLAFP00000005517}.
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DR   STRING; 9785.ENSLAFP00000005517; -.
DR   Ensembl; ENSLAFT00000006572; ENSLAFP00000005517; ENSLAFG00000006539.
DR   eggNOG; KOG2243; Eukaryota.
DR   eggNOG; ENOG410YCNW; LUCA.
DR   GeneTree; ENSGT00760000119152; -.
DR   InParanoid; G3SYE9; -.
DR   OMA; EHMPNDT; -.
DR   OrthoDB; EOG091G00T0; -.
DR   TreeFam; TF315244; -.
DR   Proteomes; UP000007646; Unassembled WGS sequence.
DR   GO; GO:0034704; C:calcium channel complex; IEA:Ensembl.
DR   GO; GO:0070062; C:extracellular exosome; IEA:Ensembl.
DR   GO; GO:0043234; C:protein complex; IEA:Ensembl.
DR   GO; GO:0033017; C:sarcoplasmic reticulum membrane; IEA:Ensembl.
DR   GO; GO:0005790; C:smooth endoplasmic reticulum; IEA:Ensembl.
DR   GO; GO:0030018; C:Z disc; IEA:Ensembl.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0048763; F:calcium-induced calcium release activity; IEA:Ensembl.
DR   GO; GO:0005516; F:calmodulin binding; IEA:Ensembl.
DR   GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR   GO; GO:0034236; F:protein kinase A catalytic subunit binding; IEA:Ensembl.
DR   GO; GO:0034237; F:protein kinase A regulatory subunit binding; IEA:Ensembl.
DR   GO; GO:0043621; F:protein self-association; IEA:Ensembl.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:Ensembl.
DR   GO; GO:0043924; F:suramin binding; IEA:Ensembl.
DR   GO; GO:0030509; P:BMP signaling pathway; IEA:Ensembl.
DR   GO; GO:0035584; P:calcium-mediated signaling using intracellular calcium source; IEA:Ensembl.
DR   GO; GO:0060070; P:canonical Wnt signaling pathway; IEA:Ensembl.
DR   GO; GO:0003300; P:cardiac muscle hypertrophy; IEA:Ensembl.
DR   GO; GO:0071313; P:cellular response to caffeine; IEA:Ensembl.
DR   GO; GO:0071872; P:cellular response to epinephrine stimulus; IEA:Ensembl.
DR   GO; GO:0005513; P:detection of calcium ion; IEA:Ensembl.
DR   GO; GO:0003143; P:embryonic heart tube morphogenesis; IEA:Ensembl.
DR   GO; GO:0072599; P:establishment of protein localization to endoplasmic reticulum; IEA:Ensembl.
DR   GO; GO:0003220; P:left ventricular cardiac muscle tissue morphogenesis; IEA:Ensembl.
DR   GO; GO:1901896; P:positive regulation of calcium-transporting ATPase activity; IEA:Ensembl.
DR   GO; GO:0010460; P:positive regulation of heart rate; IEA:Ensembl.
DR   GO; GO:0051284; P:positive regulation of sequestering of calcium ion; IEA:Ensembl.
DR   GO; GO:0098735; P:positive regulation of the force of heart contraction; IEA:Ensembl.
DR   GO; GO:0086029; P:Purkinje myocyte to ventricular cardiac muscle cell signaling; IEA:Ensembl.
DR   GO; GO:0098910; P:regulation of atrial cardiac muscle cell action potential; IEA:Ensembl.
DR   GO; GO:0098904; P:regulation of AV node cell action potential; IEA:Ensembl.
DR   GO; GO:0010881; P:regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion; IEA:Ensembl.
DR   GO; GO:0098907; P:regulation of SA node cell action potential; IEA:Ensembl.
DR   GO; GO:0098911; P:regulation of ventricular cardiac muscle cell action potential; IEA:Ensembl.
DR   GO; GO:0014808; P:release of sequestered calcium ion into cytosol by sarcoplasmic reticulum; IEA:Ensembl.
DR   GO; GO:0001666; P:response to hypoxia; IEA:Ensembl.
DR   GO; GO:0014850; P:response to muscle activity; IEA:Ensembl.
DR   GO; GO:0035994; P:response to muscle stretch; IEA:Ensembl.
DR   GO; GO:0051775; P:response to redox state; IEA:Ensembl.
DR   GO; GO:0097050; P:type B pancreatic cell apoptotic process; IEA:Ensembl.
DR   GO; GO:0086005; P:ventricular cardiac muscle cell action potential; IEA:Ensembl.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF13833; EF-hand_8; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF100909; SSF100909; 2.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF49899; SSF49899; 2.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50188; B302_SPRY; 3.
DR   PROSITE; PS50222; EF_HAND_2; 1.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000007646};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007646};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4264   4283       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4484   4504       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4558   4577       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4694   4715       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4752   4773       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4828   4851       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       94    149       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      156    203       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      211    266       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      272    329       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      337    394       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      585    795       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1011   1208       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1323   1546       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     4007   4042       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   COILED     4396   4429       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   4951 AA;  562793 MW;  75A0716662070674 CRC64;
     DDEVVLQCTA TIHKEQQKLC LAAEGFGNRL CFLESTSNSK NVPPDLSICT FVLEQSLSVR
     ALQEMLANTV EKSEGQVDVE KWVFSMQTAQ GGGHRTLLYG HAILLRHSYS GMYLSCLSTS
     RSSTDKLAFD VGLQEDTTGE ACWWTIHPAS KQRSEGEKVR VGDDLILVSV SSERYLHLSY
     GNGNGSLQVD AAFQQTLWSV APISSGSEAA QGYLIGGDVL RLLHGHMDEC LTVPAGDHGE
     EQRRNVHYEG GAVSVHARSL WRLETLRVAW SGSHIRWGQP FRLRHVTTGK YLSLLEDKSL
     LLMDKEKADV KSTAFTFRSS KEKLDVGIRK EVDGMGTSEI KYGDSVCYIQ HVDTGLWLTY
     QSVDVKSVRM GSIQRKAIMH HEGHMDDGLN LSRSQHEESR TARVIRSTVF LFNRFIRGLD
     ALSKKVKASS VDLPIESVSL SLQDLIGYFH PPDEHLEHED KQNRLRALKN RQNLFQEEGM
     INLVLECIDR LHVYSSAAHF ADVAGREAGE SWKSILNSLY ELLAALIRGN RKNCAQFSGS
     LDWLISRLER LEASSGILEV LHCVLVESPE ALNIIKEGHI KSIISLLDKH GRNHKVLDVL
     CSLCVCHGVA VRSNQHLICD NLLPGRDLLL QTRLVNHVSS MRPNIFLGVS EGSAQYKKWY
     YELMVDHTEP FVTAEATHLR VGWASTEGYS PYPGGGEEWG GNGVGDDLFS YGFDGLHLWS
     GCIARTVSSP NQHLLRTDDV ISCCLDLSAP SISFRINGQP VQGMFENFNI DGLFFPVVSF
     SAGIKVRFLL GGRHGEFKFL PPPGYAPCYE AVLPKEKLKV EHSREYKQER TYTRDLLGPT
     VSLTQAAFTP IPVDTSQIVL PPHLERIREK LAENIHELWV MNKIELGWQY GPVRDDNKRQ
     HPCLVEFSKL PEQERNYNLQ MSLETLKTLL ALGCHVGILD EHADEKVKKM KLPKNYQLTS
     GYKPAPMDLS FIKLTPSQEA MVDKLAENAH NVWARDRIRQ GWTYGIQQDV KNRRNPRLVP
     YALLDDRTKK SNKDSLREAV RTLLGYGYNL EAPDQDHAAR AEMCSGTGER FRIFRAEKTY
     AVKAGKWYFE FEAVTAGDMR VGWSRPGCQP DQELGSDERA FAFDGFKAQR WHQGNEHYGR
     SWQAGDVVGC MVDMNEHTMM FTLNGEILLD DSGSELAFKD IEVGDGFIPA CSLGVAQVGR
     MNFGKDVSTL KYFTICGLQE GYEPFAVNTN RDITMWLSKR LPQFLQVPSN HEHIEVTRID
     GTIDSSPCLK VTQKSFGSQN SSTDIMFYRL SMPIECAEVF SKTAAGGLPG ASLFGPKNDL
     EDYDADSDFE VLMKTAHGHL VPDRVDKEAT KSEFNNHKDY AQEKPSRLKQ RFLLRRTKPD
     YSTSHSARLT EDVLADDRDD YDYLMQTSTY YYSVRIFPGQ EPANVWVGWI TSDFHQYDTG
     FDLDRVRTVT VTLGDEKGKV HESIKRSNCY MVCAGESMSP GQGRNNNGLE IGCVVDAASG
     LLTFTANGKE LSTYYQVEPS TKLFPAVFAQ ATSPNVFQFE LGRIKNVMPL SAGLFKSEHK
     NPVPQCPPRL HVQFLSHVLW SRMPNQFLKV DVSRISERQG WLVQCLDPLQ FMSLHIPEEN
     RSVDILELTE QEELLKFHYH TLRLYSAVCA LGNHRVAHAL CSHVDEPQLL YAIDNKYMPG
     LLRAGYYDLL IDIHLSSYAT ARLMMNNEFI VPMTEETKSI TLFPDENKKH GLPGIGLSTS
     LRPRMQFSSP SFVSISNECY QYSPEFPLDI LKAKTIQMLT EAVKESSLHA RDPVGGTTEF
     LFVPLIKLFY TLLIMGVFHN EDLKHVLQLI EPSVFKDAAT PEEDSVVLEK ELSTEDWKLE
     GAGEEEAKGG RRPKEGLLQM KLPEPVKLQM CLLLQYLCDC QVRHRIEAIV AFSDDFVAKL
     QDNQRFRYNE VMQALNMSAA LTARKTKEFR SPPQEQINML LNFKDDKSEC PCPEEIRDQL
     LDFHEDLMTH CGIELDEDGS LDGNSDLTIR GRLLSLVEKV TYLKKKQAEK PIESDSKKSS
     TLQQLISETM VRWAQESVIE DPELVRAMFV LLHRQYDGIG GLVRALPKTY TINSVSVEDT
     INLLASLGQI RSLLSVRMGK EEEKLMIRGL GDIMNNKVFY QHPNLMRALG MHETVMEVMV
     NVLGGGESKE ITFPKMVANC CRFLCYFCRI SRQNQKAMFD HLSYLLENSS VGLASPAMRG
     STPLDVAAAS VMDNNELALA LREPDLEKVV RYLAGCGLQS CQMLVSKGYP DIGWNPVEGE
     RYLDFLRFAV FCNGESVEEN ANVVVRLLIR RPECFGPALR GEGGNGLLAA MEEAIKIAED
     PSRDGPSPTS GSSKTPDTEG EEDDTIHMGN AIMTFYSALI DLLGRCAPEM HLIHAGKGEA
     IRIRSILRSL IPLADLVGVI SIAFQMPTIA KDGNVVEPDM SAGFCPDHKA AMVLFLDRVY
     GIEDQDFLLH LLEVGFLPDL RAAASLDTAA LSATDMALAL NRYLCTAVLP LLTRCAPLFA
     GTEHHASLID SLLHTVYRLS KGCSLTKAQR DSIEVCLLSI CGQLRPSMMQ HLLRRLVFDV
     PLLNEHAKMP LKLLTNHYER CWKYYCLPGG WGNFGAASEE ELHLSRKLFW GIFDALSQKK
     YEQELFKLAL PCLSAVAGAL PPDYMESNYV SMMEKQSSVD SEGNFNPQPV DTSNITIPEK
     LEYFINKYAE HSHDKWSMDK LANGWIYGEV YSDSSKVQPL MKPYKLLSEK EKEIYRWPIK
     ESLKTMLAWG WRIERTREGD SMALYNRTRR ISQTSQVSID ITHGYSPRAI DMSNVTLSRD
     LHAMAEMMAE NYHNIWAKKK KMELESKGGG NHPLLVPYDT LTAKEKAKDR EKAQDILKFL
     QINGYAVSRG FKDLELDTPS IEKRFAYSFL QQLIRYVDEA HQYILEFDGG SRSKGEPFPY
     EQEIKFFAKV VLPLIDQYFK NHRLYFLSAA SRPLCSGGHA SNKEKEMVTS LFCKLGVLVR
     HRISLFGNDA TSIVNCLHIL GQTLDARTVM KTGLESVKSA LRAFLDNAAE DLEKTMENLK
     QGQFTHTRNQ PRGVTQIINY TTVALLPMLS SLFEHIGQHQ FGEDLILEDV QVSCYRILTS
     LYTLGTSKSI YVERQRSALG ECLAAFAGAF PVAFLETHLD KHNVYSIYNT KSSRERAALN
     LPSNVEDVCP NIPSLEKLMD EIVELAESGI RYTQMPHVME VILPMLCSYM SRWWEHGPEN
     NPERAEMCCT ALNSEHMNTL LGNILKIIYN NLGIDEGAWM KRLAVFSQPI INKVKPQLLK
     THFLPLMEKL KKKAALVVSE EDHMKAEARG DMSEAELLIL DEFTTLARDL YAFYPLLIRF
     VDYNRAKWLK EPNPEAEELF RMVAEVFIYW SKSHNFKREE QNFVVQNEIN NMSFLITDTK
     SKMSKAAVSD QERKKMKRKG DRYSMQTSLI VAALKRLLPI GLNICAPGDQ ELIALAKNRF
     SLKDTEDEVR DIIRNNIHLQ GKLEDPAIRW QMALYKDLPN RTEDTSDPEK TVERVLDIAN
     VLFHLEQVRF CIYLIIFAQV EHPQRSKKAV WHKLLSKQRK RAVVACFRMA PLYNLPRHRA
     VNLFLQGYEK SWIETEEHYF EDKLIEDLAK PGAEPPEEDE GTKRVDPLHQ LILLFSRTAL
     TEKCKLEEDF LYMAYADIMA KSCHDEEDDD GEEEVKSFEE KEMEKQKLLY QQARLHDRGA
     AEMVLQTISA SKGEMGPMVA ATLKLGIAIL NGGNSTVQQK MLDYLKEKKD VGFFQSLAGL
     MQSCSVLDLN AFERQNKAEG LGMVTEEGSG EKVLQDDEFT CDLFRFLQLL CEGHNSDFQN
     YLRTQTGNNT TVNIIISTVD YLLRVQESIS DFYWYYSGKD VIDEQGQRNF SKAIQVAKQV
     FNTLTEYIQG PCTGNQQSLA HSRLWDAVVG FLHVFAHMQM KLSQDSSQIE LLKELMDLQK
     DMVVMLLSML EGNVVNGTIG KQMVDMLVES SNNVEMILKF FDMFLKLKDL TSSDTFKEYD
     PDGKGVISKR DFHKAMESHK HYTQSETEFL LSCAETDENE TLDYEEFVKR FHEPAKDIGF
     NVAVLLTNLS EHMPNDTRLQ TFLELAESVL NYFQPFLGRI EIMGSAKRIE RVYFEISESS
     RTQWEKPQVK ESKRQFIFDV VNEGGEKEKM ELFVNFCEDT IFEMQLAAQI SESDLNERST
     NKEESEKEKP EEQEPRMGFF SIRTVKSALF ALRYNILTLM RMLSLKSLKK QMKKMKKMTM
     KDMVTAFFSS YWSIFLNLLH FVASVFRGFF RIVCSLLLGG SLVEGAKKIK VAELLANMPD
     PTQDEVRGDG EDGERKPMEV ALPSEDLTDL KELTEESDLL SDIFGLDLKR EGGQYKLIPH
     NPNAGLSDLM SNPVPIPEVQ EKFQEQKAKE EEKEEKEETK SEPEKAEGED GEKEEKAKED
     KGKQKLRQLH THRYGEPEVP ESAFWKKIIA YQQKLLNYFA RNFYNMRMLA LFVAFAINFI
     LLFYKVSTSS VVEGKELPPR SSGENAKVSS LDSGSQRIIA VHYVLEESSG YMEPTLRILA
     ILHTVISFFC IIGYYCLKVP LVIFKREKEV ARKLEFDGLY ITEQPSEDDI KGQWDRLVIN
     TQSFPNNYWD KFVKRKVMDK YGEFYGRDRI SELLGMDKAA LDFSDAREKK KPKKDSSLSA
     VLNSIDVKYQ MWKLGVVFTD NSFLYLAWYM TMSILGHYNN FFFAAHLLDI AMGFKTLRTI
     LSSVTHNGKQ LVLTVGLLAV VVYLYTVVAF NFFRKFYNKS EDGDTPDMKC DDMLTCYMFH
     MYVGVRAGGG IGDEIEDPAG DEYEIYRIIF DITFFFFVIV ILLAIIQGLI IDAFGELRDQ
     QEQVKEDMET KCFICGIGND YFDTVPHGFE THTLQEHNLA NYLFFLMYLI NKDETEHTGQ
     ESYVWKMYQE RCWEFFPAGD CFRKQYEDQL N
//
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