GenomeNet

Database: UniProt
Entry: G3SZS3_LOXAF
LinkDB: G3SZS3_LOXAF
Original site: G3SZS3_LOXAF 
ID   G3SZS3_LOXAF            Unreviewed;       853 AA.
AC   G3SZS3;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   27-SEP-2017, entry version 29.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
GN   Name=ATP6V0A2 {ECO:0000313|Ensembl:ENSLAFP00000006145};
OS   Loxodonta africana (African elephant).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta.
OX   NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000006145, ECO:0000313|Proteomes:UP000007646};
RN   [1] {ECO:0000313|Ensembl:ENSLAFP00000006145}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000006145};
RA   Di Palma F., Heiman D., Young S., Johnson J., Lander E.S.,
RA   Lindblad-Toh K.;
RT   "The Genome Sequence of Loxodonta africana (African elephant).";
RL   Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSLAFP00000006145}
RP   IDENTIFICATION.
RC   STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000006145};
RG   Ensembl;
RL   Submitted (SEP-2011) to UniProtKB.
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-
CC       ATPase), a multimeric enzyme that catalyzes the translocation of
CC       protons across the membranes. Required for assembly and activity
CC       of the V-ATPase. {ECO:0000256|RuleBase:RU361189}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|RuleBase:RU361189}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSLAFP00000006145}.
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DR   STRING; 9785.ENSLAFP00000006145; -.
DR   Ensembl; ENSLAFT00000007311; ENSLAFP00000006145; ENSLAFG00000007308.
DR   eggNOG; KOG2189; Eukaryota.
DR   eggNOG; COG1269; LUCA.
DR   GeneTree; ENSGT00390000004941; -.
DR   InParanoid; G3SZS3; -.
DR   OMA; TIPSFMN; -.
DR   OrthoDB; EOG091G01BI; -.
DR   TreeFam; TF300346; -.
DR   Proteomes; UP000007646; Unassembled WGS sequence.
DR   GO; GO:0001669; C:acrosomal vesicle; IEA:Ensembl.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005765; C:lysosomal membrane; IEA:Ensembl.
DR   GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR   GO; GO:0015078; F:hydrogen ion transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0015991; P:ATP hydrolysis coupled proton transport; IEA:InterPro.
DR   GO; GO:0006879; P:cellular iron ion homeostasis; IEA:Ensembl.
DR   GO; GO:0036295; P:cellular response to increased oxygen levels; IEA:Ensembl.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR   PANTHER; PTHR11629; PTHR11629; 1.
DR   Pfam; PF01496; V_ATPase_I; 1.
DR   PIRSF; PIRSF001293; ATP6V0A1; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000007646};
KW   Hydrogen ion transport {ECO:0000256|RuleBase:RU361189};
KW   Ion transport {ECO:0000256|RuleBase:RU361189};
KW   Membrane {ECO:0000256|RuleBase:RU361189};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007646};
KW   Transmembrane {ECO:0000256|RuleBase:RU361189};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361189};
KW   Transport {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    406    430       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    451    468       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    554    572       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    584    607       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    651    674       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    786    808       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   COILED       94    128       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   853 AA;  97647 MW;  21F5F2E804D7E358 CRC64;
     MGSLFRSESM CLAQLFLQAG TAYECLSALG ERGLVQFRDL NQSVSSFQRK FVGEMKRCEE
     LERILAYLVQ EINKADIPLP EGETSPPAPP LKQVLEMQEQ LQKLEVELRE VTKNKEKLRK
     NLLELIEYTH MLRVTKTFVK RNVEFEPAYE EFSSLETESL IDYSCMQRLG AKLGFVSGLI
     NQGKVEAFEK MLWRVCKGYT IVTYAELDEP LEDPETGEVI KWYVFLISFW GEQIGYKVKK
     ICDCYHCHIY PYPNTAEERK EIQEGLNTRI QDLYTVLHKT EDYLRQVLCN AAETVYSRVI
     QVKKMKAIYH MLNMCSFDVT NKCLIAEVWC PEADLQELRR ALEDGSRESG ATIPSFMNTI
     PTKETPPTLI RTNKFTEGFQ NIVDAYGVGS YREVNPALFT IITFPFLFAV MFGDFGHGFV
     MFLFALLLVL NENHPRLKQS QEILRMFFDG RYILLLMGLF SVYTGLIYND CFSKSVNIFG
     SGWNVSAMYS SSHAAKEPKK LILWNNSVVR HNRVLQLDPS VPGVFQGPYP FGIDPIWNLA
     TNRLTFLNSF KMKMSVILGI IHMTFGVTLG ICNHLHFRKK FNIYLVSIPE LLFMLCIFGY
     LIFMIIYKWL VYSAETSRVA PSILIEFINM FLFPASETVG LYPGQAPVQR LLLAITALSV
     PVLVLGKPLF LLWLHNGRGC FGVSRSGYTL VRKDSEEEVS LLGSQDIEEG SNHMEDRCRE
     VTNEEFNFGE ILMTQVIHSI EYCLGCISNT ASYLRLWALS LAHAQLSDVL WAMLMRVGLR
     VDTTYGVLLL LPVMAFFAIL TIFILLVMEG LSAFLHAIRL HWVEFQNKFY TGAGTKFVPF
     SFNLLSSKFN NDD
//
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