ID G3T1A0_LOXAF Unreviewed; 623 AA.
AC G3T1A0;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 63.
DE SubName: Full=Matrilin 4 {ECO:0000313|Ensembl:ENSLAFP00000006830.4};
GN Name=MATN4 {ECO:0000313|Ensembl:ENSLAFP00000006830.4};
OS Loxodonta africana (African elephant).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta.
OX NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000006830.4, ECO:0000313|Proteomes:UP000007646};
RN [1] {ECO:0000313|Ensembl:ENSLAFP00000006830.4, ECO:0000313|Proteomes:UP000007646}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000006830.4,
RC ECO:0000313|Proteomes:UP000007646};
RA Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Loxodonta africana (African elephant).";
RL Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLAFP00000006830.4}
RP IDENTIFICATION.
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000006830.4};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
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DR AlphaFoldDB; G3T1A0; -.
DR Ensembl; ENSLAFT00000008144.4; ENSLAFP00000006830.4; ENSLAFG00000008138.4.
DR GeneTree; ENSGT00940000157086; -.
DR Proteomes; UP000007646; Unassembled WGS sequence.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR CDD; cd00054; EGF_CA; 1.
DR Gene3D; 1.20.5.30; -; 1.
DR Gene3D; 2.10.25.10; Laminin; 4.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 2.
DR InterPro; IPR026823; cEGF.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR036337; Matrilin_cc_sf.
DR InterPro; IPR019466; Matrilin_coiled-coil_trimer.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR24020; COLLAGEN ALPHA; 1.
DR PANTHER; PTHR24020:SF14; MATRILIN-4; 1.
DR Pfam; PF12662; cEGF; 1.
DR Pfam; PF14670; FXa_inhibition; 1.
DR Pfam; PF00092; VWA; 2.
DR PRINTS; PR00453; VWFADOMAIN.
DR SMART; SM00181; EGF; 4.
DR SMART; SM00179; EGF_CA; 4.
DR SMART; SM01279; Matrilin_ccoil; 1.
DR SMART; SM00327; VWA; 2.
DR SUPFAM; SSF58002; Chicken cartilage matrix protein; 1.
DR SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR SUPFAM; SSF53300; vWA-like; 2.
DR PROSITE; PS01186; EGF_2; 1.
DR PROSITE; PS50234; VWFA; 2.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536};
KW Reference proteome {ECO:0000313|Proteomes:UP000007646};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..623
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003454813"
FT DOMAIN 36..215
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 388..563
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
SQ SEQUENCE 623 AA; 68168 MW; BCD6F066738FED14 CRC64;
MRGLLCSPLP LLLLLLLPWE TQLQFTGPKC RSGPLDLVFV IDSSRSVRPF EFETMRQFLV
GLLRGLDVGP NATRVGVIQY SSQVQSVFPL GAFSRHEDME RAIRALVPLA QGTMTGLAIQ
YAMNVAFSVA EGARPPEARV PRVAVIVTDG RPQDRVAEVA AQARARGIEI YAVGVQRADV
GSLRAMASPP LNEHVFLVES FDLIQEFGLQ FQGRLCGKDL CAEGGHGCQH QCVSALDMYH
CTCNPGYQLA ADNKSCLAVD LCAQGTHGCA HHCVSSPGSY SCRCRAGFVL QRDQRSCRAI
DHCSFGNHSC QHECVSTLSG PRCHCREGHD LLSDGRRCQA RDLCNGVDHG CEFRCVSDGL
SYRCLCPEGR QLQADGKSCS RCREGHVDLV LLVDGSKSVR PQNFELVKRF VNQIVDFLDV
SPEGTRVGLV QFSSRVRTEF PLGRYGTAAE VKQAVLAIEY MERGTMTGMA LRHLVEHSFS
EAQGARPRAL NVPRVGLVFT DGRSQDDISL WAARAKEEGI VMYAVGVGKA VEEELREIAS
EPSELHVSYS PDFSTMAHLL ENLKGSICPE EGISAGTELR SPCDCESLME FQGRTLGALD
SLTQNSFLTA RLEALENQLA NQK
//
