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Database: UniProt
Entry: G3T3S0_LOXAF
LinkDB: G3T3S0_LOXAF
Original site: G3T3S0_LOXAF 
ID   G3T3S0_LOXAF            Unreviewed;       819 AA.
AC   G3T3S0;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   30-AUG-2017, entry version 43.
DE   SubName: Full=Two pore segment channel 1 {ECO:0000313|Ensembl:ENSLAFP00000007930};
GN   Name=TPCN1 {ECO:0000313|Ensembl:ENSLAFP00000007930};
OS   Loxodonta africana (African elephant).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta.
OX   NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000007930};
RN   [1] {ECO:0000313|Ensembl:ENSLAFP00000007930}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000007930};
RA   Di Palma F., Heiman D., Young S., Johnson J., Lander E.S.,
RA   Lindblad-Toh K.;
RT   "The Genome Sequence of Loxodonta africana (African elephant).";
RL   Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSLAFP00000007930}
RP   IDENTIFICATION.
RC   STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000007930};
RG   Ensembl;
RL   Submitted (SEP-2011) to UniProtKB.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSLAFP00000007930}.
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DR   RefSeq; XP_003419391.2; XM_003419343.2.
DR   RefSeq; XP_010597261.1; XM_010598959.1.
DR   Ensembl; ENSLAFT00000009457; ENSLAFP00000007930; ENSLAFG00000009454.
DR   GeneID; 100676831; -.
DR   KEGG; lav:100676831; -.
DR   CTD; 53373; -.
DR   eggNOG; ENOG410INF7; Eukaryota.
DR   eggNOG; ENOG410XZT8; LUCA.
DR   GeneTree; ENSGT00530000063660; -.
DR   KO; K16896; -.
DR   Proteomes; UP000007646; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005245; F:voltage-gated calcium channel activity; IEA:InterPro.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR028801; TPC1.
DR   PANTHER; PTHR10037:SF262; PTHR10037:SF262; 1.
DR   Pfam; PF00520; Ion_trans; 2.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000007646};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007646};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    108    130       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    136    154       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    236    255       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    262    281       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    301    324       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    446    466       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    478    496       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    508    527       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    571    595       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    667    692       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      108    331       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      442    691       Ion_trans. {ECO:0000259|Pfam:PF00520}.
SQ   SEQUENCE   819 AA;  94855 MW;  43E58B86199EE891 CRC64;
     MAVSLDDDVP LILTLDEGSS TPLAPSNGLA QEELPSKNGS SYAIDDSRDP SLSSGGESFP
     PSPTRHNWEM NYQEAAIYLQ EGENNDKFFT HPKDAKALAA YLFVHNHLFY LMELLTALLL
     LLLSLCEAPA VPALRLGIYV HATLELFALM VVVFELCMKL RWLGLHTFIR HKRTMVKTSV
     LVVQFIEAIV VLVRQTSHVR VTRALRCIFL VDCRYCGGVR RNLRQIFQSL PPFMDILLLL
     LFFMTIFAIL GFYLFSPNPS DPYFNTLENS IISLFVLLTT ANFPDVMMPS YSRNPWSCVF
     FIVYLSIELY FIMNLLLAVV FDTFNDIEKH KFKSLLLHKR TAIQHAYRLL ISQRRPAGIS
     YRQFEGLMRF YKPRMNAGER YLTFKALNQS NTPQLSLKDF YDIYEVAALK WKAKKNREHW
     FDELPRTAFL IFKGINILVK SKAYQYFMYL VVAVNGIWIL VETFMLKGGN FFAKHVPWSY
     LVFLTIYGVE LFLKVAGLGP VEYLSSGWNL FDFSVTVFAF LGLLALAFNM EPFYFIVVLR
     PLQLLRLFKL KKRYRNVLDT MFELLPRMGS LGLTLLIFYY SFAIVGMEFF CGILYPNCCN
     LSTVADAYRW VNHTVGNKTM VEEGYYYLNN FDNILNSFVT LFELTVVNNW YIIMEGVTSQ
     TSHWSRLYFM TFYIVTMVVM TIIVAFILEA FVFRMNYSRK NQDSEVDSGI TLEKELSKEE
     LVTILELYRE VRGAASDVTR LLKTLSQMER HEQNSVVFLG RRSRTKSDLS LKMYQEEIQE
     WYQEHARRQE EQQRQLSGSG GVPSTQQPPG SRQRSQTIT
//
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