ID G3T3V9_LOXAF Unreviewed; 1094 AA.
AC G3T3V9;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 46.
DE SubName: Full=Rho GTPase activating protein 39 {ECO:0000313|Ensembl:ENSLAFP00000007986.3};
GN Name=ARHGAP39 {ECO:0000313|Ensembl:ENSLAFP00000007986.3};
OS Loxodonta africana (African elephant).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta.
OX NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000007986.3, ECO:0000313|Proteomes:UP000007646};
RN [1] {ECO:0000313|Ensembl:ENSLAFP00000007986.3, ECO:0000313|Proteomes:UP000007646}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000007986.3,
RC ECO:0000313|Proteomes:UP000007646};
RA Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Loxodonta africana (African elephant).";
RL Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLAFP00000007986.3}
RP IDENTIFICATION.
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000007986.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; G3T3V9; -.
DR Ensembl; ENSLAFT00000009522.3; ENSLAFP00000007986.3; ENSLAFG00000009522.3.
DR GeneTree; ENSGT00390000003161; -.
DR HOGENOM; CLU_005171_0_0_1; -.
DR Proteomes; UP000007646; Unassembled WGS sequence.
DR GO; GO:0005856; C:cytoskeleton; IEA:InterPro.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd04389; RhoGAP_KIAA1688; 1.
DR Gene3D; 2.20.70.10; -; 1.
DR Gene3D; 1.25.40.530; MyTH4 domain; 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR000857; MyTH4_dom.
DR InterPro; IPR038185; MyTH4_dom_sf.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR InterPro; IPR001202; WW_dom.
DR InterPro; IPR036020; WW_dom_sf.
DR PANTHER; PTHR45876; FI04035P; 1.
DR PANTHER; PTHR45876:SF1; RHO GTPASE-ACTIVATING PROTEIN 39; 1.
DR Pfam; PF00784; MyTH4; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00139; MyTH4; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SMART; SM00456; WW; 2.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF51045; WW domain; 1.
DR PROSITE; PS51016; MYTH4; 1.
DR PROSITE; PS50238; RHOGAP; 1.
DR PROSITE; PS50020; WW_DOMAIN_2; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000007646}.
FT DOMAIN 37..71
FT /note="WW"
FT /evidence="ECO:0000259|PROSITE:PS50020"
FT DOMAIN 702..854
FT /note="MyTH4"
FT /evidence="ECO:0000259|PROSITE:PS51016"
FT DOMAIN 901..1089
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 86..154
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 197..239
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 257..286
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 305..343
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 381..407
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 420..514
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 545..570
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 86..118
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 199..238
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 257..279
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 443..465
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 477..491
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1094 AA; 123285 MW; 6F72D5F8F053E4C6 CRC64;
RLEWVEIIEP RTRERMYANL VTGECVWDPP TGVRIKRTSD NQWWELFDPN TSRFYYYNAT
TQRTVWHRPQ NCDIIPLAKL QTLKQNTESP RVSAESSPGR GSAISREGSP STSLEPEPDT
SEKAQELPGQ TGRPVPFGAT KEEHGGSSSP PGVFLEKDYE TYRDYGMDGP LLHYRASSLQ
WTTGTKERML IKVTDREPSF FTPQGNGFPT DGQPGARTQR PSSGQHSPGL QTFTPDTDSA
IFFPERRLSP FLKRTELTGS CSPLQDPRKP SSDSQPSSPR YAYEPPLYEE PPVEYQAPIY
DEPPVDMQYE VSGGYKAGSP QKSPVRKPRP FLQSPKHASP SPYQQLVLTK QRGPERFLSL
DYSPAGKEYV RQLVYVEQAG SSPKLRAGPR HKYAPNPGGG SYSLQPSPCL VRDQRLEARS
GDYSSMEGPD FRHGPPSTPL PPAQDDTMSW CSQQDTMSST GCSPGPRKRK SRKPSLCQDP
HTSSTDGSGD RNPLSEPLLA EERPPCGPSV APLKRADGRL GEAEGARGAC EPFLAQARLA
WEAQQVHHHM KQRSSWDSQK DGSGYESDGA VPLPMPGPVV RAFSEDEALA QQESKHWKRS
TFEKLGFPQI LLEKSISVQT NLASPEPYLH PSQSEDLGSC AQFESGRQGR SMVPSASCVF
PAFTLRKPSS ETDIENWASK HFNKHTQGLF RRKVSIANML AWSSESIKKP MIMTSDRHVK
KEACEIFKLI QMYMGDRRAK ADPLHVALEV ATKGWSTQGL RDELYIQLCR QTTENFRLES
LARGWELMAI CLAFFPPTPK FHSYLEGYIY RHMDPVNDTK VTQHIKELLE RNTKKKSKLR
KKPKPYVEEP DGVAISTYAK YCYHKLQKAA LTGAKKGLRK PTVEEIRHAK NAVFSPSMFG
SALQEVMSMQ KERYPERQLP WVQTRLSEEV LALNGDQTEG IFRVPGDIDE VNALKLQVDQ
WKVPTGLEDP HVPASLLKLW YRELEEPLIP HEFYDQCIAH YESPEAAVAV VHALPRINRM
VLCYLIRFLQ VFVQPANVAI TKMDVSNLAM VMAPNCLRCQ SDDPRVIFEN TRKEMSFLRV
LIQHLDTSFM EGVL
//
