ID   G3T979_LOXAF            Unreviewed;      4224 AA.
AC   G3T979;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   27-MAR-2024, entry version 75.
DE   SubName: Full=Dynein axonemal heavy chain 5 {ECO:0000313|Ensembl:ENSLAFP00000010314.4};
GN   Name=DNAH5 {ECO:0000313|Ensembl:ENSLAFP00000010314.4};
OS   Loxodonta africana (African elephant).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta.
OX   NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000010314.4, ECO:0000313|Proteomes:UP000007646};
RN   [1] {ECO:0000313|Ensembl:ENSLAFP00000010314.4, ECO:0000313|Proteomes:UP000007646}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000010314.4,
RC   ECO:0000313|Proteomes:UP000007646};
RA   Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., Lindblad-Toh K.;
RT   "The Genome Sequence of Loxodonta africana (African elephant).";
RL   Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSLAFP00000010314.4}
RP   IDENTIFICATION.
RC   STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000010314.4};
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the dynein heavy chain family.
CC       {ECO:0000256|ARBA:ARBA00008887}.
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DR   STRING; 9785.ENSLAFP00000010314; -.
DR   Ensembl; ENSLAFT00000012334.4; ENSLAFP00000010314.4; ENSLAFG00000012310.4.
DR   eggNOG; KOG3595; Eukaryota.
DR   GeneTree; ENSGT00940000155533; -.
DR   InParanoid; G3T979; -.
DR   OMA; FQKRDRY; -.
DR   TreeFam; TF316836; -.
DR   Proteomes; UP000007646; Unassembled WGS sequence.
DR   GO; GO:0097728; C:9+0 motile cilium; IEA:Ensembl.
DR   GO; GO:0097729; C:9+2 motile cilium; IEA:Ensembl.
DR   GO; GO:0005576; C:extracellular region; IEA:GOC.
DR   GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR   GO; GO:0036157; C:outer dynein arm; IEA:Ensembl.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR   GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR   GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR   GO; GO:0007368; P:determination of left/right symmetry; IEA:Ensembl.
DR   GO; GO:0003351; P:epithelial cilium movement involved in extracellular fluid movement; IEA:Ensembl.
DR   GO; GO:0051649; P:establishment of localization in cell; IEA:Ensembl.
DR   GO; GO:0030317; P:flagellated sperm motility; IEA:Ensembl.
DR   GO; GO:0007507; P:heart development; IEA:Ensembl.
DR   GO; GO:0021670; P:lateral ventricle development; IEA:Ensembl.
DR   GO; GO:0036158; P:outer dynein arm assembly; IEA:Ensembl.
DR   Gene3D; 1.10.287.2620; -; 1.
DR   Gene3D; 1.10.472.130; -; 1.
DR   Gene3D; 1.10.8.1220; -; 1.
DR   Gene3D; 1.10.8.710; -; 1.
DR   Gene3D; 1.20.58.1120; -; 1.
DR   Gene3D; 1.20.920.20; -; 1.
DR   Gene3D; 1.20.920.30; -; 1.
DR   Gene3D; 6.10.140.1060; -; 1.
DR   Gene3D; 1.20.140.100; Dynein heavy chain, N-terminal domain 2; 1.
DR   Gene3D; 3.20.180.20; Dynein heavy chain, N-terminal domain 2; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 5.
DR   Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR035699; AAA_6.
DR   InterPro; IPR035706; AAA_9.
DR   InterPro; IPR041658; AAA_lid_11.
DR   InterPro; IPR042219; AAA_lid_11_sf.
DR   InterPro; IPR026983; DHC_fam.
DR   InterPro; IPR041589; DNAH3_AAA_lid_1.
DR   InterPro; IPR042222; Dynein_2_N.
DR   InterPro; IPR043157; Dynein_AAA1S.
DR   InterPro; IPR041466; Dynein_AAA5_ext.
DR   InterPro; IPR024743; Dynein_HC_stalk.
DR   InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR   InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR   InterPro; IPR013602; Dynein_heavy_linker.
DR   InterPro; IPR013594; Dynein_heavy_tail.
DR   InterPro; IPR042228; Dynein_linker_3.
DR   InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR46532:SF13; DYNEIN CYTOPLASMIC 1 HEAVY CHAIN 1; 1.
DR   PANTHER; PTHR46532; MALE FERTILITY FACTOR KL5; 1.
DR   Pfam; PF12774; AAA_6; 1.
DR   Pfam; PF12775; AAA_7; 1.
DR   Pfam; PF12780; AAA_8; 1.
DR   Pfam; PF12781; AAA_9; 1.
DR   Pfam; PF17857; AAA_lid_1; 1.
DR   Pfam; PF18198; AAA_lid_11; 1.
DR   Pfam; PF08385; DHC_N1; 1.
DR   Pfam; PF08393; DHC_N2; 1.
DR   Pfam; PF17852; Dynein_AAA_lid; 1.
DR   Pfam; PF03028; Dynein_heavy; 1.
DR   Pfam; PF12777; MT; 1.
DR   SMART; SM00382; AAA; 3.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
DR   PROSITE; PS00018; EF_HAND_1; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW   Cilium {ECO:0000256|ARBA:ARBA00023069};
KW   Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW   Dynein {ECO:0000256|ARBA:ARBA00023017};
KW   Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW   Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007646};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT   DOMAIN          1957..2093
FT                   /note="AAA+ ATPase"
FT                   /evidence="ECO:0000259|SMART:SM00382"
FT   DOMAIN          2236..2391
FT                   /note="AAA+ ATPase"
FT                   /evidence="ECO:0000259|SMART:SM00382"
FT   DOMAIN          2564..2712
FT                   /note="AAA+ ATPase"
FT                   /evidence="ECO:0000259|SMART:SM00382"
FT   REGION          875..909
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          3190..3227
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          3420..3454
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          3725..3752
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        875..903
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   4224 AA;  483741 MW;  652F37C25D3F586C CRC64;
     QKLKEEKEAK RAHLDGRHNY LFSIVASCVD LNKAEVEDAI LEGNQIERID QLFVAGGLRH
     LVFYYQDVEV AETGQLTPSG GVNLASGKIT KPKVFVTEGK DVALTGVCVF FIRTDPSKAI
     TPENIHREVC FNMLDTADGG LLNSMRRLLS DIFIPALKAT DHGWGEHDGL QEASSIRQDF
     LCSLEGFVGV LSSAQESLKE KVNLQKCDAF ELKTLREPMD YLAIANNPEI LEKIEGCMKV
     WIKQTEQVLA ENNQLRKEAD DLGPRAELEH WKKRLSKFNY LLDQLKRPDV KAALAVLAAA
     RSKLLKTWRE MDIRITDAAN EAKDNVKYLY TLEKCCDPLY SSDPISMIDA IPTLINAIKM
     IYSISHYYNT SEKITSLFVK VTNQMISACK AYISNNGTAS IWNQPQDVVV EKILSTIKLK
     QEYQHCFHKT KQKLKQIPNE KQFEFSEMYI FGKFETFHRR LAKILDIFTT FKTYSVLRDS
     KIEGLENLIA MFQGIVVTIK KKEYNFLDQR KMEFDQDYEE FCKQTNDLHN ELQKFMDVTF
     EKIQNTNQAL SMLKKFERLN IPNLGIDDKY RLILENYGAD IDMISKLYTK HKYDPPLGRD
     QPPIAGKILW ARQLFHRIQQ PMQLFQQHPT VLQTAEAKPI IRSYNRIAKV LLEFEVLYHR
     AWLQQIEEIH VGLEASLLVK APGTGELFVN FDPQILTLFR ETECMSQMGL EVSPFAAALF
     QKRDIYKKNF SNMKMMLAEY QRVKSKMPPT IEQLMAPHLA KVDETLQSGL AALNWTSLNI
     EAYLESTFEK IKELELLLNR VNDLIEFRID AILEEMSSTP LCQLPQEEPL TCEEFLQMTK
     DLCVNGAQIL HFKSSLVEEA VNELINMLLD VEVPSKEESE KGSKENRVDL QSDSSEKKEG
     KSDTLTSSLN ASETGAGLLP FMMIKKKKKE TVMLEEEACE LLSHFNHQNA DALLKVTRNT
     LEAIRKRIHA SHTVHFRDRN NISKMKPNSL PIFQAGITLA IPHIAMTPAL EDIQQTLNKA
     VECIVSVPKG VRQWSSELLS TKKMRERKMA ALRNNEDSDS DNDMGENELQ DTLEIASVHL
     PISVQPKNYY KNVADNKEIV KLVSVLSTII NSTKKEVITS LDCFKCYNHI WQKEKEETVM
     TFIVKNPLLS EFESQILYFQ NLEQEINAEP EHICVGCIAL YTADLKLALT AETKAWMTVI
     GRHCNKKYRS EMENIFTLVE EFNKKLNRQI KDLDDIRIAM AALKEIREQQ IAIDFQVGPI
     EESYALLNKY GLLIAKEEMD KVDTLRYAWQ KLLARASDVQ KELVSLQPSF RKELVSTVEV
     FLQDCHQFYL DYDLNGPMAI GLKPQEASDR LIMFQNQFDN IYRKYITYTG GEELFGLPVT
     QYPQLLEIKK QLNLLQKIYT LYNTVIETVN SYHDILWSEV NIEKINNELL EFQNRCRKLP
     RALKDWQAFL DLKKTIDDFS ECCPLLEHMA NKAMMARHWE RITALTGHHL DVGNETFKLR
     NIMEAPLLKY KEEIEDICIS AVKERDIEQK LKQVINEWHN KSFTFGSFKT RGELLLRGDS
     TSEIITNMED SLMLLGSLLS NRYNMPFKAQ IQKWVQYLSN STDIIENWMT VQNLWIYLEA
     VFVGGDIAKQ LPKEAKRFSN IDKSWVKIMT RHEMPNVVQC CVGDETMGQL LPHLLDQLEI
     CQKSLTGYLE KKRLCFPRFF FVSDPALLEI LGQASDSHTI QAHLLNVFDN IKTVKFHEKI
     YDRILSISSR EGETIELGKP VMAEGNVEVW LNSLLEESQS SLHLVIRQAA ASIQETGFQL
     IEFLSSFPAQ VGLLGIQMIW TRDSEEALTN AKSEKKIMQK TNQSFLDLLN TLIDITTKDL
     SSVERVKYET LITIHVHQRD IFDDLCQMHV KSPTDFEWLK QCRFYFHEDS DKMKIHVTDV
     NFTYQNEFLG CTERLVITPL TDRCYITLAQ ALGMSMGGAP AGPAGTGKTE TTKDMGRCLG
     KYVVVFNCSD QMDFRGLGRI FKGLAQSGSW GCFDEFNRID LPVLSVAAQQ ISIILTCKKE
     RKKSFIFTDG DNVTMNPEFG LFLTMNPGYA GRQELPENLK INFRSVAMMV PDRQIIIRVK
     MASCGFVDNI VLARKFFTLY KLCEEQLSKQ VHYDFGLRNI LSVLRTLGAA KRANPTDTES
     TIVMRVLRDM NLSKLIDEDE PLFLSLIEDL FPNILLDKAG YPELETAISR QVEEAGLINH
     LPWKLKVIQL FETQRVRHGI MTLGPSGAGK TTCIHTLMKA MTDCGKPHRE MRMNPKAITA
     PQMFGRLDVA TNDWTDGIFS TLWRKTLRAK KGEHIWIVLD GPVDAIWIEN LNSVLDDNKT
     LTLANGDRIP MAPNCKIIFE PHNIDNASPA TVSRNGMVFM SSSILDWSPI LEGFLKKRSS
     QEAEVLRQLY TKSFPDLYRF SAQNLEFKME MLEAFVIMQS INMLQGLIPL KEQGGEITSE
     HLGRLYIFSL MWSIGAVLEL DGRRRVEHWL RSQDSLTLDL PTLGGVEDTM FDYYVTLDGK
     WMHWNTCTEE YMYPSHTTPE YSSILVPNVD NVRTDFLIKT IAKQGKAVLL IGEQGTAKTV
     IIKGFMSKYD PESHMIKSLN FSSATTPLMF QRTIESYVDK RMGTTYGPPA GKKMTIFIDD
     VNMPIINEWG DQVTNEIVRQ LMEHNGFYNL EKPGEFTSIV DIQFLAAMIH PGGGRNDIPQ
     RLKRQFSVFN CTLPSDASMD KIFGVIGVGY YCSQRGFPEE VSDLVAKLVP LTRRLWQMTK
     MKMLPTPAKF HYVFNLRDLS RIWQGMLNTT SKVIKESDAL LRLWKHECKR VIADRFTVSE
     DVTWFDKALV SLVEEEFGEE KKLFVDCGID DYFVDFLRDA PEATGQTSEE EADVEMPKIY
     EPIESFNHLK ERLNMFLQLY NESIRGAGMD MVFFEDAMVH LVKISRIIRT PRGNALLVGV
     GGSGKQSLTR LASFIAGYSS FQITLTRSYN TSNLMEDLKI LYRTAGQRGK GITFIFTDNE
     IKEESFLEYM NNVLSSGEVS NLFARDEVDE ITSDLASVMK REFPRRPPTN ENLYDYFMSR
     VRQNLHIVLC FSPVGEKFRN RALKFPALIS GCTVDWFSRW PKDALVAVSE HFLSSYDIDC
     SLETKKEVVQ CMGSFQDGVA EKCVDYFQRF RRSTHVTPKS YLSFIQGYKL IYGEKRAEVQ
     TLANRMNTGL EKLKEASESV AALSKELEVK EKELQVANEK ADTVLKEVTM KAQAAEKVKA
     EVQKVKDKAQ AIVDSISKDK AIAEEKLEAA KPALEEAEAA LQTIKPSDIA TVRTLGRPPH
     LIMRIMDCVL LLFQRRVNAV KTDPERGCTA PSWQESLKLM TAGNFLQNLQ QFPKDTINEE
     VIEFLNPYFE MADYNIETAK RVCGNVAGLC SWTKAMASFF SINKEVLPLK ANLVVQENRH
     VLAMQDLQKA QAELDDKQAE LDVVQAEYEQ AMIEKQDLVS SDRRCQHSLN LSQTIKSGLF
     IPTILEAWII ATMIMKCFSD ILFSILGDVL LATAFLSYSG PFNQEFRNLL LNDWQKEMKA
     RKIPFGSNLN LNEMLIDAPT ISEWNLQGLP NDDLSIQNGI IVTKASRYPL LIDPQTQGKI
     WIKNKENRNE LQITSLNHKY FRNHLEDSLS LGRPLLIEDV GEELDPALDN VLERNFIKTG
     STFKKVKVGD KEADVMDGFR LYITTKLPNP AYTPEISART SIIDFTVTMR GLEDQLLGRV
     ILTEKQELEK ERTHLMEDVT ANKRRMKELE DNLLYRLTST QGSLVEDESL IIVLSNTKRT
     AEEVTQKLEI SAETEIQINS AREEYRPVAT RGSILYFLIT EMRLVNEMYQ TSLRQFLGLF
     DLSLARSVKS PVTSKRIANI IEHMTYEVYK YAARGLYEEH KFLFTLLLTL KIDIQRNRVK
     HEEFLTLIKG GASLDLKACP AKPSKWILDM TWLNLVELSK LRQFSDVLDQ ISRNEKMWKI
     WFDKENPEEE PFPNAYDKSL DCFRRLLLIR SWCPDRTIAQ ARKYIMDSMG ENYAEGIILD
     LEKTWEESDP RTPLICLLSM GSDPTDSIIA LGKRLKIETR YVSMGQGQEV HARKLLQQTM
     ASGGWALLQN CHLGLDFMEE LMAIITEAET VHDAFRLWMT TEVHKQFPIT LLQMSIKFAN
     EPPQGLRAGL KRTYGGVSQD LLDVSTVAQW KPMLYAVAFL HSTVQERRKF GPLGWNIPYE
     FNQADFNATV QFIQNHLDDM DIKK
//