ID G3TA20_LOXAF Unreviewed; 317 AA.
AC G3TA20;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 64.
DE SubName: Full=Hydroxysteroid 17-beta dehydrogenase 6 {ECO:0000313|Ensembl:ENSLAFP00000010676.3};
GN Name=HSD17B6 {ECO:0000313|Ensembl:ENSLAFP00000010676.3};
OS Loxodonta africana (African elephant).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta.
OX NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000010676.3, ECO:0000313|Proteomes:UP000007646};
RN [1] {ECO:0000313|Ensembl:ENSLAFP00000010676.3, ECO:0000313|Proteomes:UP000007646}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000010676.3,
RC ECO:0000313|Proteomes:UP000007646};
RA Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Loxodonta africana (African elephant).";
RL Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLAFP00000010676.3}
RP IDENTIFICATION.
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000010676.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the short-chain dehydrogenases/reductases (SDR)
CC family. {ECO:0000256|RuleBase:RU000363}.
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DR RefSeq; XP_003405610.1; XM_003405562.1.
DR AlphaFoldDB; G3TA20; -.
DR STRING; 9785.ENSLAFP00000010676; -.
DR Ensembl; ENSLAFT00000012768.3; ENSLAFP00000010676.3; ENSLAFG00000012770.3.
DR GeneID; 100657790; -.
DR KEGG; lav:100657790; -.
DR eggNOG; KOG1610; Eukaryota.
DR GeneTree; ENSGT00940000162028; -.
DR HOGENOM; CLU_010194_2_0_1; -.
DR InParanoid; G3TA20; -.
DR OMA; FFDAYHD; -.
DR OrthoDB; 5403248at2759; -.
DR TreeFam; TF325617; -.
DR Proteomes; UP000007646; Unassembled WGS sequence.
DR GO; GO:0047024; F:5alpha-androstane-3beta,17beta-diol dehydrogenase activity; IEA:Ensembl.
DR GO; GO:0047044; F:androstan-3-alpha,17-beta-diol dehydrogenase activity; IEA:Ensembl.
DR GO; GO:0047023; F:androsterone dehydrogenase activity; IEA:Ensembl.
DR GO; GO:0004303; F:estradiol 17-beta-dehydrogenase [NAD(P)] activity; IEA:Ensembl.
DR GO; GO:0004745; F:NAD-retinol dehydrogenase activity; IEA:Ensembl.
DR GO; GO:0047045; F:testosterone 17-beta-dehydrogenase (NADP+) activity; IEA:Ensembl.
DR GO; GO:0047035; F:testosterone dehydrogenase (NAD+) activity; IEA:Ensembl.
DR GO; GO:0062175; P:brexanolone catabolic process; IEA:Ensembl.
DR CDD; cd09805; type2_17beta_HSD-like_SDR_c; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR020904; Sc_DH/Rdtase_CS.
DR InterPro; IPR002347; SDR_fam.
DR PANTHER; PTHR43313:SF4; 17-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 6; 1.
DR PANTHER; PTHR43313; SHORT-CHAIN DEHYDROGENASE/REDUCTASE FAMILY 9C; 1.
DR Pfam; PF00106; adh_short; 1.
DR PRINTS; PR00081; GDHRDH.
DR PRINTS; PR00080; SDRFAMILY.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS00061; ADH_SHORT; 1.
PE 3: Inferred from homology;
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000007646}.
SQ SEQUENCE 317 AA; 36235 MW; D3C9C904AC7C2E5B CRC64;
MWLYLVGLVS LYYLLRWYRE RQVVSHLRDK YVFITGCDSG FGNLLARQLD LRGLRVLAAC
LTEQGATQLR SQTSDRLETV ILDVTQTESI TAATQWVKER VGDRGLWGLV NNAGIISPFG
HSEWLKIETY VNILKVNLMG LIEVTLSMLP LVKRARGRIV NVSSILGRIA FFAGIYCSSK
YGVEAFSDAL RRELQHFGVK ISIVEPGYFR TGMTDMQQSL EAVKRAWEEA PTDIKETYGQ
HFFDAYCDLM KQVLSKCNTN LNWVTDCMEH ALTSMHPRTR YSAGWDARFF YIPLSYLPTS
LADYILTRPW PKPAQAF
//
