ID G3TAU5_LOXAF Unreviewed; 369 AA.
AC G3TAU5;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 62.
DE SubName: Full=Alcohol dehydrogenase 6 (class V) {ECO:0000313|Ensembl:ENSLAFP00000011030.3};
GN Name=ADH6 {ECO:0000313|Ensembl:ENSLAFP00000011030.3};
OS Loxodonta africana (African elephant).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta.
OX NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000011030.3, ECO:0000313|Proteomes:UP000007646};
RN [1] {ECO:0000313|Ensembl:ENSLAFP00000011030.3, ECO:0000313|Proteomes:UP000007646}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000011030.3,
RC ECO:0000313|Proteomes:UP000007646};
RA Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Loxodonta africana (African elephant).";
RL Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLAFP00000011030.3}
RP IDENTIFICATION.
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000011030.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947,
CC ECO:0000256|RuleBase:RU361277};
CC -!- SIMILARITY: Belongs to the zinc-containing alcohol dehydrogenase
CC family. {ECO:0000256|RuleBase:RU361277}.
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DR AlphaFoldDB; G3TAU5; -.
DR STRING; 9785.ENSLAFP00000011030; -.
DR Ensembl; ENSLAFT00000013178.3; ENSLAFP00000011030.3; ENSLAFG00000013178.3.
DR eggNOG; KOG0022; Eukaryota.
DR GeneTree; ENSGT00940000163645; -.
DR HOGENOM; CLU_026673_14_0_1; -.
DR InParanoid; G3TAU5; -.
DR OMA; QVNEGYQ; -.
DR TreeFam; TF300429; -.
DR Proteomes; UP000007646; Unassembled WGS sequence.
DR GO; GO:0004022; F:alcohol dehydrogenase (NAD+) activity; IEA:Ensembl.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0006069; P:ethanol oxidation; IEA:Ensembl.
DR GO; GO:0045471; P:response to ethanol; IEA:Ensembl.
DR Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR013149; ADH-like_C.
DR InterPro; IPR013154; ADH-like_N.
DR InterPro; IPR002328; ADH_Zn_CS.
DR InterPro; IPR011032; GroES-like_sf.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR43880; ALCOHOL DEHYDROGENASE; 1.
DR PANTHER; PTHR43880:SF20; ALCOHOL DEHYDROGENASE 6; 1.
DR Pfam; PF08240; ADH_N; 1.
DR Pfam; PF00107; ADH_zinc_N; 1.
DR SUPFAM; SSF50129; GroES-like; 2.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS00059; ADH_ZINC; 1.
PE 3: Inferred from homology;
KW Metal-binding {ECO:0000256|RuleBase:RU361277};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000007646};
KW Zinc {ECO:0000256|RuleBase:RU361277}.
FT DOMAIN 35..156
FT /note="Alcohol dehydrogenase-like N-terminal"
FT /evidence="ECO:0000259|Pfam:PF08240"
FT DOMAIN 199..325
FT /note="Alcohol dehydrogenase-like C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00107"
SQ SEQUENCE 369 AA; 40022 MW; 55166797C378F506 CRC64;
MSTTGKVIKC RAAIFWKPGT PFSTEEVEVS PPKAKEIRIK IIATGFCGTE KKRVKSLSKF
PSILGHEGAG IVESVGEGVS VVKTGDKVIT FFLPQCGERT SFLNSEDNFC IKFNEGHTRL
MSDGTTRFTC RGKSLYHFGN TSTFSEYTVM KEISVTKIDA GAPLEKVCLI SCGFTSYGAA
IKTAKISGGG HCRLHLCRVG LSVIIGCKAA RAARIIRVDI NKDKFEKAKE VGTTECISPH
DFKKPIQEVL FMIGAGADFC FEVIGNPETV GAALASCHES HGVCVIVGFS TAGVQFNISG
SLFFSGRSLK GTVFGSWKSR EHVPKLVSDY MAKKFNLNPL ITQTLNFDNI SEVTELMKTG
KCICCVLML
//
