ID G3TC20_LOXAF Unreviewed; 327 AA.
AC G3TC20;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 61.
DE SubName: Full=Salvador family WW domain containing protein 1 {ECO:0000313|Ensembl:ENSLAFP00000011569.2};
GN Name=SAV1 {ECO:0000313|Ensembl:ENSLAFP00000011569.2};
OS Loxodonta africana (African elephant).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta.
OX NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000011569.2, ECO:0000313|Proteomes:UP000007646};
RN [1] {ECO:0000313|Ensembl:ENSLAFP00000011569.2, ECO:0000313|Proteomes:UP000007646}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000011569.2,
RC ECO:0000313|Proteomes:UP000007646};
RA Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Loxodonta africana (African elephant).";
RL Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLAFP00000011569.2}
RP IDENTIFICATION.
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000011569.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; G3TC20; -.
DR STRING; 9785.ENSLAFP00000011569; -.
DR Ensembl; ENSLAFT00000013814.2; ENSLAFP00000011569.2; ENSLAFG00000013815.2.
DR eggNOG; KOG1891; Eukaryota.
DR GeneTree; ENSGT00940000156106; -.
DR HOGENOM; CLU_060422_0_0_1; -.
DR InParanoid; G3TC20; -.
DR OMA; AARYYYP; -.
DR TreeFam; TF317631; -.
DR Proteomes; UP000007646; Unassembled WGS sequence.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005634; C:nucleus; IEA:Ensembl.
DR GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR GO; GO:0060090; F:molecular adaptor activity; IEA:InterPro.
DR GO; GO:0060038; P:cardiac muscle cell proliferation; IEA:Ensembl.
DR GO; GO:0050673; P:epithelial cell proliferation; IEA:Ensembl.
DR GO; GO:0001942; P:hair follicle development; IEA:Ensembl.
DR GO; GO:0035329; P:hippo signaling; IEA:Ensembl.
DR GO; GO:0060575; P:intestinal epithelial cell differentiation; IEA:Ensembl.
DR GO; GO:0097283; P:keratinocyte apoptotic process; IEA:Ensembl.
DR GO; GO:0030216; P:keratinocyte differentiation; IEA:Ensembl.
DR GO; GO:0060487; P:lung epithelial cell differentiation; IEA:Ensembl.
DR GO; GO:0060044; P:negative regulation of cardiac muscle cell proliferation; IEA:Ensembl.
DR GO; GO:0050680; P:negative regulation of epithelial cell proliferation; IEA:Ensembl.
DR GO; GO:0045600; P:positive regulation of fat cell differentiation; IEA:Ensembl.
DR GO; GO:1902174; P:positive regulation of keratinocyte apoptotic process; IEA:Ensembl.
DR GO; GO:0050821; P:protein stabilization; IEA:Ensembl.
DR GO; GO:2000036; P:regulation of stem cell population maintenance; IEA:Ensembl.
DR GO; GO:0060412; P:ventricular septum morphogenesis; IEA:Ensembl.
DR CDD; cd00201; WW; 2.
DR Gene3D; 2.20.70.10; -; 2.
DR InterPro; IPR030030; Sav.
DR InterPro; IPR001202; WW_dom.
DR InterPro; IPR036020; WW_dom_sf.
DR PANTHER; PTHR47522:SF2; PROTEIN SALVADOR HOMOLOG 1; 1.
DR PANTHER; PTHR47522; SALVADOR FAMILY WW DOMAIN-CONTAINING PROTEIN 1; 1.
DR Pfam; PF00397; WW; 1.
DR SMART; SM00456; WW; 2.
DR SUPFAM; SSF51045; WW domain; 2.
DR PROSITE; PS50020; WW_DOMAIN_2; 2.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000007646}.
FT DOMAIN 200..233
FT /note="WW"
FT /evidence="ECO:0000259|PROSITE:PS50020"
FT DOMAIN 235..268
FT /note="WW"
FT /evidence="ECO:0000259|PROSITE:PS50020"
SQ SEQUENCE 327 AA; 37794 MW; 8A6886FA871EAD77 CRC64;
MLSRKKTKNE VSKPAEVQGK YVKKETSPLL RNLMPSFIRH GPTIPRRTDI CLPDSNPNAF
SASGDGVVSR NQSFLRTPVQ RTHHEIMRRE SNRLSAPSYL ARSLADVPRE YGSSQSFLTE
VNFAVENGDS SSRFYYSDSF FDGQRRRPLG DRVQEDYRYY EYNHDLFQRM PQNQGRHASG
IGRVAATSLG NLTNHSSEDL PLPPGWSVDW TMRGRKYYID HNTNTTHWSH PLEREGLPPG
WERVESSEFG TYYVDHINKK AQYRHPCAPS VPRYDQPPPV TYQPQQTERN QSLLVPANPY
HTAEIPDWLQ VYARAPVKYD HILKWTL
//
