ID G3TDE1_LOXAF Unreviewed; 548 AA.
AC G3TDE1;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 54.
DE RecName: Full=Mannosyltransferase {ECO:0000256|RuleBase:RU363075};
DE EC=2.4.1.- {ECO:0000256|RuleBase:RU363075};
GN Name=PIGB {ECO:0000313|Ensembl:ENSLAFP00000012160.4};
OS Loxodonta africana (African elephant).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta.
OX NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000012160.4, ECO:0000313|Proteomes:UP000007646};
RN [1] {ECO:0000313|Ensembl:ENSLAFP00000012160.4, ECO:0000313|Proteomes:UP000007646}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000012160.4,
RC ECO:0000313|Proteomes:UP000007646};
RA Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Loxodonta africana (African elephant).";
RL Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLAFP00000012160.4}
RP IDENTIFICATION.
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000012160.4};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Mannosyltransferase involved in glycosylphosphatidylinositol-
CC anchor biosynthesis. Transfers the third alpha-1,2-mannose to Man2-
CC GlcN-acyl-PI during GPI precursor assembly.
CC {ECO:0000256|ARBA:ARBA00025591}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|RuleBase:RU363075}; Multi-pass membrane protein
CC {ECO:0000256|RuleBase:RU363075}.
CC -!- SIMILARITY: Belongs to the glycosyltransferase 22 family.
CC {ECO:0000256|RuleBase:RU363075}.
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DR AlphaFoldDB; G3TDE1; -.
DR STRING; 9785.ENSLAFP00000012160; -.
DR Ensembl; ENSLAFT00000014512.4; ENSLAFP00000012160.4; ENSLAFG00000014508.4.
DR eggNOG; KOG1771; Eukaryota.
DR GeneTree; ENSGT00950000183090; -.
DR HOGENOM; CLU_012353_2_0_1; -.
DR InParanoid; G3TDE1; -.
DR OMA; FNNYGYL; -.
DR TreeFam; TF313518; -.
DR Proteomes; UP000007646; Unassembled WGS sequence.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0000030; F:mannosyltransferase activity; IEA:Ensembl.
DR GO; GO:0006506; P:GPI anchor biosynthetic process; IEA:Ensembl.
DR GO; GO:0097502; P:mannosylation; IEA:Ensembl.
DR InterPro; IPR005599; GPI_mannosylTrfase.
DR PANTHER; PTHR22760; GLYCOSYLTRANSFERASE; 1.
DR PANTHER; PTHR22760:SF4; GPI MANNOSYLTRANSFERASE 3; 1.
DR Pfam; PF03901; Glyco_transf_22; 1.
PE 3: Inferred from homology;
KW Endoplasmic reticulum {ECO:0000256|RuleBase:RU363075};
KW Glycosyltransferase {ECO:0000256|RuleBase:RU363075};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU363075};
KW Reference proteome {ECO:0000313|Proteomes:UP000007646};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU363075};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU363075}.
FT TRANSMEM 52..73
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363075"
FT TRANSMEM 217..239
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363075"
FT TRANSMEM 251..270
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363075"
FT TRANSMEM 303..323
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363075"
FT TRANSMEM 335..351
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363075"
FT TRANSMEM 357..376
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363075"
FT TRANSMEM 383..401
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363075"
SQ SEQUENCE 548 AA; 63880 MW; E850078C3CC68A39 CRC64;
MEREGGDGSL FFRGLQSRTH EKMKLRKRKS ALYLSAQEAS AGRRRDLLGE NIYLVMFTIA
LRIFNCFLVQ TSFVPDEYWQ SLEVAHHMVF KNYGYLTWEW TERLRGYTYP LIFASIYKIL
HLLGKDSVQL LLLKIWVPRL AQALLSAIAD VKLYSLMKQL ENQETARWVF FCQLCSWFTW
YCCTRTLTNT METVLTTIAL FYYPLEGSKS MNSVKYSSLV ALAFLVRPTA VIPWVPLLFR
HFWLEHRKLD LILYHFLPVG FVTLGLSLII DRIFFGQWTL VQFNFLKFNV LQNLGTFYGS
HPWHWYFSQG LPVVLGTHLP FFIHGCFLAP KRYRILLVTV LWTVLVYSMV SHKEFRFIYP
VLPFCMVFCG HSLNHLKVWK KPAVSFLFLS NVLLTLYTGL VHQRGALDVM SHIQELCPSS
HGTSAASVFV MMPCHSTPSY SHVHCPLPMR FLQCPPDLTG KSHYLDEADT FYLNPLNWLY
KEFHNDSSLP THLIIFSILE EEISAFLISS NYERTDIIFH THLPEGRIGS HIHIYERKLK
GKLDRSSS
//