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Database: UniProt
Entry: G3TEN1_LOXAF
LinkDB: G3TEN1_LOXAF
Original site: G3TEN1_LOXAF 
ID   G3TEN1_LOXAF            Unreviewed;      1061 AA.
AC   G3TEN1;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   24-JAN-2024, entry version 69.
DE   RecName: Full=Valine--tRNA ligase, mitochondrial {ECO:0000256|ARBA:ARBA00040837};
DE            EC=6.1.1.9 {ECO:0000256|ARBA:ARBA00013169};
DE   AltName: Full=Valyl-tRNA synthetase {ECO:0000256|ARBA:ARBA00029936};
GN   Name=VARS2 {ECO:0000313|Ensembl:ENSLAFP00000012717.3};
OS   Loxodonta africana (African elephant).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta.
OX   NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000012717.3, ECO:0000313|Proteomes:UP000007646};
RN   [1] {ECO:0000313|Ensembl:ENSLAFP00000012717.3, ECO:0000313|Proteomes:UP000007646}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000012717.3,
RC   ECO:0000313|Proteomes:UP000007646};
RA   Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., Lindblad-Toh K.;
RT   "The Genome Sequence of Loxodonta africana (African elephant).";
RL   Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSLAFP00000012717.3}
RP   IDENTIFICATION.
RC   STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000012717.3};
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + L-valine + tRNA(Val) = AMP + diphosphate + L-valyl-
CC         tRNA(Val); Xref=Rhea:RHEA:10704, Rhea:RHEA-COMP:9672, Rhea:RHEA-
CC         COMP:9708, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57762,
CC         ChEBI:CHEBI:78442, ChEBI:CHEBI:78537, ChEBI:CHEBI:456215; EC=6.1.1.9;
CC         Evidence={ECO:0000256|ARBA:ARBA00001624};
CC   -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000256|ARBA:ARBA00004173}.
CC   -!- SIMILARITY: Belongs to the class-I aminoacyl-tRNA synthetase family.
CC       {ECO:0000256|ARBA:ARBA00005594, ECO:0000256|RuleBase:RU363035}.
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DR   RefSeq; XP_003422517.1; XM_003422469.2.
DR   AlphaFoldDB; G3TEN1; -.
DR   STRING; 9785.ENSLAFP00000012717; -.
DR   Ensembl; ENSLAFT00000015186.3; ENSLAFP00000012717.3; ENSLAFG00000015183.3.
DR   GeneID; 100669813; -.
DR   KEGG; lav:100669813; -.
DR   CTD; 57176; -.
DR   eggNOG; KOG0432; Eukaryota.
DR   GeneTree; ENSGT00940000159890; -.
DR   HOGENOM; CLU_001493_0_1_1; -.
DR   InParanoid; G3TEN1; -.
DR   OMA; RQWYIRN; -.
DR   OrthoDB; 5473263at2759; -.
DR   TreeFam; TF354250; -.
DR   Proteomes; UP000007646; Unassembled WGS sequence.
DR   GO; GO:0002161; F:aminoacyl-tRNA editing activity; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004832; F:valine-tRNA ligase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006438; P:valyl-tRNA aminoacylation; IEA:InterPro.
DR   CDD; cd07962; Anticodon_Ia_Val; 1.
DR   CDD; cd00817; ValRS_core; 1.
DR   Gene3D; 3.40.50.620; HUPs; 2.
DR   Gene3D; 3.90.740.10; Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain; 2.
DR   InterPro; IPR001412; aa-tRNA-synth_I_CS.
DR   InterPro; IPR002300; aa-tRNA-synth_Ia.
DR   InterPro; IPR033705; Anticodon_Ia_Val.
DR   InterPro; IPR013155; M/V/L/I-tRNA-synth_anticd-bd.
DR   InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR   InterPro; IPR009080; tRNAsynth_Ia_anticodon-bd.
DR   InterPro; IPR009008; Val/Leu/Ile-tRNA-synth_edit.
DR   InterPro; IPR002303; Valyl-tRNA_ligase.
DR   NCBIfam; TIGR00422; valS; 1.
DR   PANTHER; PTHR11946:SF71; VALINE--TRNA LIGASE, MITOCHONDRIAL; 1.
DR   PANTHER; PTHR11946; VALYL-TRNA SYNTHETASES; 1.
DR   Pfam; PF08264; Anticodon_1; 1.
DR   Pfam; PF00133; tRNA-synt_1; 1.
DR   PRINTS; PR00986; TRNASYNTHVAL.
DR   SUPFAM; SSF47323; Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases; 1.
DR   SUPFAM; SSF52374; Nucleotidylyl transferase; 1.
DR   SUPFAM; SSF50677; ValRS/IleRS/LeuRS editing domain; 1.
DR   PROSITE; PS00178; AA_TRNA_LIGASE_I; 1.
PE   3: Inferred from homology;
KW   Aminoacyl-tRNA synthetase {ECO:0000256|ARBA:ARBA00023146,
KW   ECO:0000256|RuleBase:RU363035};
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU363035};
KW   Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000256|RuleBase:RU363035};
KW   Mitochondrion {ECO:0000256|ARBA:ARBA00023128};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW   ECO:0000256|RuleBase:RU363035};
KW   Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917,
KW   ECO:0000256|RuleBase:RU363035};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007646};
KW   Transit peptide {ECO:0000256|ARBA:ARBA00022946}.
FT   DOMAIN          113..736
FT                   /note="Aminoacyl-tRNA synthetase class Ia"
FT                   /evidence="ECO:0000259|Pfam:PF00133"
FT   DOMAIN          780..928
FT                   /note="Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase
FT                   anticodon-binding"
FT                   /evidence="ECO:0000259|Pfam:PF08264"
FT   REGION          12..74
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        38..54
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1061 AA;  118113 MW;  B6E09C9D0FA3B513 CRC64;
     MFHLPLASFR PPLWGLRPSR GLPRPRPLST QSEPHGSPIS RRNREAKQKR LQERQAALEA
     GISGKNKPPA ESSKAWTPKE IVLYEVPTEP GEKKDVSRPL PPAYSPQYVE AAWYPWWVRE
     GFFKPEYKAQ LPQATGETFS MCIPPPNVTG SLHIGHALTV AIQDALVRWH RMRGDQVLWV
     PGSDHAGIAT QAVVEKQLWK EQGLRRHELS REAFLREVWK WKEEKGGEIC EQLRVLGASL
     DWDRECFTMD AGSSVAVTEA FVRLYKAGLL YRNRQLVNWS CALRSAISDI EVESRALPGH
     TQLQLPGCPV PVSFGLLVFI AFPVDGEPDA EVVVGTTRPE TLPGDVAVAI HPDDSRYTHL
     HGRQLRHPLT GHLLPLITDS AVQPHVGTGA VKVTPAHSPA DAEMGARHGL SPQSVIAEDG
     TMTLLCGDWL QGLHRFVARE KIMCVLRERG LFRGLQSHPM VLRICSRSGD VVECLLKSQW
     FVRCREMGDQ AAKAVESGAL GLHPPYHQKN WQHWFSHIGD WCISRQLWWG HQIPAYLVVE
     EQTENVGEGC WVVGRSEAEA RQAAAELTGR PGEELTLERD PDVLDTWFSS ALFPFSALGW
     PQETPDLARF YPLSLLETGS DLLLFWVGRM VMLGTQLTGQ LPFSKVLLHS MVRDRQGRKM
     SKSLGNVLDP RDIISGAELQ VLQEKLKDGN LDPAELAIAA AAQRKDFPHG IPECGTDALR
     FTLCSHGALG GDLNLSVTEV LSSRHFCNKI WNALRFILNV LGEKFTPQPA EELSPSSPVD
     AWILSRLALT ARECERGFRT CELSLVTHTL HHFWLHNLCD TYLEAVKPVV ARSPCPSGPP
     QILFSCADVG LRLLAPLMPF LAEELWQRLP TRPGCASAPS ICVAPYPSAC SLEHWHQPEL
     ERCFSRVQEA AQALRALRAT YQLTKARPRV LLQSSEQSKQ GLFEAFLEPL GTLGHCGAVG
     LLPPGMAAPS GWAQAPLSDG IQIFMELQGL VDPQTHLPLL AARRHKLQKQ LENLLTRTPS
     QGEAETQRQQ RLSSLQVELS KLDKAASHLQ QLMEESQLRE C
//
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