ID G3TEN1_LOXAF Unreviewed; 1061 AA.
AC G3TEN1;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 24-JAN-2024, entry version 69.
DE RecName: Full=Valine--tRNA ligase, mitochondrial {ECO:0000256|ARBA:ARBA00040837};
DE EC=6.1.1.9 {ECO:0000256|ARBA:ARBA00013169};
DE AltName: Full=Valyl-tRNA synthetase {ECO:0000256|ARBA:ARBA00029936};
GN Name=VARS2 {ECO:0000313|Ensembl:ENSLAFP00000012717.3};
OS Loxodonta africana (African elephant).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta.
OX NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000012717.3, ECO:0000313|Proteomes:UP000007646};
RN [1] {ECO:0000313|Ensembl:ENSLAFP00000012717.3, ECO:0000313|Proteomes:UP000007646}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000012717.3,
RC ECO:0000313|Proteomes:UP000007646};
RA Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Loxodonta africana (African elephant).";
RL Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLAFP00000012717.3}
RP IDENTIFICATION.
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000012717.3};
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-valine + tRNA(Val) = AMP + diphosphate + L-valyl-
CC tRNA(Val); Xref=Rhea:RHEA:10704, Rhea:RHEA-COMP:9672, Rhea:RHEA-
CC COMP:9708, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57762,
CC ChEBI:CHEBI:78442, ChEBI:CHEBI:78537, ChEBI:CHEBI:456215; EC=6.1.1.9;
CC Evidence={ECO:0000256|ARBA:ARBA00001624};
CC -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000256|ARBA:ARBA00004173}.
CC -!- SIMILARITY: Belongs to the class-I aminoacyl-tRNA synthetase family.
CC {ECO:0000256|ARBA:ARBA00005594, ECO:0000256|RuleBase:RU363035}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_003422517.1; XM_003422469.2.
DR AlphaFoldDB; G3TEN1; -.
DR STRING; 9785.ENSLAFP00000012717; -.
DR Ensembl; ENSLAFT00000015186.3; ENSLAFP00000012717.3; ENSLAFG00000015183.3.
DR GeneID; 100669813; -.
DR KEGG; lav:100669813; -.
DR CTD; 57176; -.
DR eggNOG; KOG0432; Eukaryota.
DR GeneTree; ENSGT00940000159890; -.
DR HOGENOM; CLU_001493_0_1_1; -.
DR InParanoid; G3TEN1; -.
DR OMA; RQWYIRN; -.
DR OrthoDB; 5473263at2759; -.
DR TreeFam; TF354250; -.
DR Proteomes; UP000007646; Unassembled WGS sequence.
DR GO; GO:0002161; F:aminoacyl-tRNA editing activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004832; F:valine-tRNA ligase activity; IEA:UniProtKB-EC.
DR GO; GO:0006438; P:valyl-tRNA aminoacylation; IEA:InterPro.
DR CDD; cd07962; Anticodon_Ia_Val; 1.
DR CDD; cd00817; ValRS_core; 1.
DR Gene3D; 3.40.50.620; HUPs; 2.
DR Gene3D; 3.90.740.10; Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain; 2.
DR InterPro; IPR001412; aa-tRNA-synth_I_CS.
DR InterPro; IPR002300; aa-tRNA-synth_Ia.
DR InterPro; IPR033705; Anticodon_Ia_Val.
DR InterPro; IPR013155; M/V/L/I-tRNA-synth_anticd-bd.
DR InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR InterPro; IPR009080; tRNAsynth_Ia_anticodon-bd.
DR InterPro; IPR009008; Val/Leu/Ile-tRNA-synth_edit.
DR InterPro; IPR002303; Valyl-tRNA_ligase.
DR NCBIfam; TIGR00422; valS; 1.
DR PANTHER; PTHR11946:SF71; VALINE--TRNA LIGASE, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11946; VALYL-TRNA SYNTHETASES; 1.
DR Pfam; PF08264; Anticodon_1; 1.
DR Pfam; PF00133; tRNA-synt_1; 1.
DR PRINTS; PR00986; TRNASYNTHVAL.
DR SUPFAM; SSF47323; Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases; 1.
DR SUPFAM; SSF52374; Nucleotidylyl transferase; 1.
DR SUPFAM; SSF50677; ValRS/IleRS/LeuRS editing domain; 1.
DR PROSITE; PS00178; AA_TRNA_LIGASE_I; 1.
PE 3: Inferred from homology;
KW Aminoacyl-tRNA synthetase {ECO:0000256|ARBA:ARBA00023146,
KW ECO:0000256|RuleBase:RU363035};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU363035};
KW Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000256|RuleBase:RU363035};
KW Mitochondrion {ECO:0000256|ARBA:ARBA00023128};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU363035};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917,
KW ECO:0000256|RuleBase:RU363035};
KW Reference proteome {ECO:0000313|Proteomes:UP000007646};
KW Transit peptide {ECO:0000256|ARBA:ARBA00022946}.
FT DOMAIN 113..736
FT /note="Aminoacyl-tRNA synthetase class Ia"
FT /evidence="ECO:0000259|Pfam:PF00133"
FT DOMAIN 780..928
FT /note="Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase
FT anticodon-binding"
FT /evidence="ECO:0000259|Pfam:PF08264"
FT REGION 12..74
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 38..54
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1061 AA; 118113 MW; B6E09C9D0FA3B513 CRC64;
MFHLPLASFR PPLWGLRPSR GLPRPRPLST QSEPHGSPIS RRNREAKQKR LQERQAALEA
GISGKNKPPA ESSKAWTPKE IVLYEVPTEP GEKKDVSRPL PPAYSPQYVE AAWYPWWVRE
GFFKPEYKAQ LPQATGETFS MCIPPPNVTG SLHIGHALTV AIQDALVRWH RMRGDQVLWV
PGSDHAGIAT QAVVEKQLWK EQGLRRHELS REAFLREVWK WKEEKGGEIC EQLRVLGASL
DWDRECFTMD AGSSVAVTEA FVRLYKAGLL YRNRQLVNWS CALRSAISDI EVESRALPGH
TQLQLPGCPV PVSFGLLVFI AFPVDGEPDA EVVVGTTRPE TLPGDVAVAI HPDDSRYTHL
HGRQLRHPLT GHLLPLITDS AVQPHVGTGA VKVTPAHSPA DAEMGARHGL SPQSVIAEDG
TMTLLCGDWL QGLHRFVARE KIMCVLRERG LFRGLQSHPM VLRICSRSGD VVECLLKSQW
FVRCREMGDQ AAKAVESGAL GLHPPYHQKN WQHWFSHIGD WCISRQLWWG HQIPAYLVVE
EQTENVGEGC WVVGRSEAEA RQAAAELTGR PGEELTLERD PDVLDTWFSS ALFPFSALGW
PQETPDLARF YPLSLLETGS DLLLFWVGRM VMLGTQLTGQ LPFSKVLLHS MVRDRQGRKM
SKSLGNVLDP RDIISGAELQ VLQEKLKDGN LDPAELAIAA AAQRKDFPHG IPECGTDALR
FTLCSHGALG GDLNLSVTEV LSSRHFCNKI WNALRFILNV LGEKFTPQPA EELSPSSPVD
AWILSRLALT ARECERGFRT CELSLVTHTL HHFWLHNLCD TYLEAVKPVV ARSPCPSGPP
QILFSCADVG LRLLAPLMPF LAEELWQRLP TRPGCASAPS ICVAPYPSAC SLEHWHQPEL
ERCFSRVQEA AQALRALRAT YQLTKARPRV LLQSSEQSKQ GLFEAFLEPL GTLGHCGAVG
LLPPGMAAPS GWAQAPLSDG IQIFMELQGL VDPQTHLPLL AARRHKLQKQ LENLLTRTPS
QGEAETQRQQ RLSSLQVELS KLDKAASHLQ QLMEESQLRE C
//