ID G3TF43_LOXAF Unreviewed; 1940 AA.
AC G3TF43;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 66.
DE RecName: Full=Myosin-4 {ECO:0000256|ARBA:ARBA00044107};
DE AltName: Full=Myosin heavy chain 2b {ECO:0000256|ARBA:ARBA00044300};
DE AltName: Full=Myosin heavy chain 4 {ECO:0000256|ARBA:ARBA00044226};
GN Name=MYH1 {ECO:0000313|Ensembl:ENSLAFP00000012921.3};
OS Loxodonta africana (African elephant).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta.
OX NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000012921.3, ECO:0000313|Proteomes:UP000007646};
RN [1] {ECO:0000313|Ensembl:ENSLAFP00000012921.3, ECO:0000313|Proteomes:UP000007646}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000012921.3,
RC ECO:0000313|Proteomes:UP000007646};
RA Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Loxodonta africana (African elephant).";
RL Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLAFP00000012921.3}
RP IDENTIFICATION.
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000012921.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Muscle contraction. {ECO:0000256|ARBA:ARBA00037488}.
CC -!- SUBUNIT: Muscle myosin is a hexameric protein that consists of 2 heavy
CC chain subunits (MHC), 2 alkali light chain subunits (MLC) and 2
CC regulatory light chain subunits (MLC-2).
CC {ECO:0000256|ARBA:ARBA00038612}.
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Myosin family. {ECO:0000256|ARBA:ARBA00008314,
CC ECO:0000256|PROSITE-ProRule:PRU00782}.
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DR Ensembl; ENSLAFT00000015421.3; ENSLAFP00000012921.3; ENSLAFG00000015427.3.
DR GeneTree; ENSGT00940000154760; -.
DR Proteomes; UP000007646; Unassembled WGS sequence.
DR GO; GO:0030016; C:myofibril; IEA:UniProtKB-SubCell.
DR GO; GO:0016459; C:myosin complex; IEA:UniProtKB-KW.
DR GO; GO:0051015; F:actin filament binding; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003774; F:cytoskeletal motor activity; IEA:UniProtKB-UniRule.
DR CDD; cd14915; MYSc_Myh4; 1.
DR Gene3D; 1.10.10.820; -; 1.
DR Gene3D; 1.20.5.340; -; 5.
DR Gene3D; 1.20.5.370; -; 4.
DR Gene3D; 1.20.5.4820; -; 1.
DR Gene3D; 1.20.58.530; -; 1.
DR Gene3D; 6.10.250.2420; -; 1.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 1.
DR Gene3D; 2.30.30.360; Myosin S1 fragment, N-terminal; 1.
DR Gene3D; 1.20.120.720; Myosin VI head, motor domain, U50 subdomain; 1.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR001609; Myosin_head_motor_dom.
DR InterPro; IPR004009; Myosin_N.
DR InterPro; IPR008989; Myosin_S1_N.
DR InterPro; IPR002928; Myosin_tail.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR014751; XRCC4-like_C.
DR PANTHER; PTHR45615; MYOSIN HEAVY CHAIN, NON-MUSCLE; 1.
DR PANTHER; PTHR45615:SF78; MYOSIN-4; 1.
DR Pfam; PF00063; Myosin_head; 1.
DR Pfam; PF02736; Myosin_N; 1.
DR Pfam; PF01576; Myosin_tail_1; 1.
DR PRINTS; PR00193; MYOSINHEAVY.
DR SMART; SM00242; MYSc; 1.
DR SUPFAM; SSF90257; Myosin rod fragments; 4.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS50096; IQ; 1.
DR PROSITE; PS51456; MYOSIN_MOTOR; 1.
DR PROSITE; PS51844; SH3_LIKE; 1.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Myosin {ECO:0000256|ARBA:ARBA00023123, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00782}; Reference proteome {ECO:0000313|Proteomes:UP000007646}.
FT DOMAIN 33..82
FT /note="Myosin N-terminal SH3-like"
FT /evidence="ECO:0000259|PROSITE:PS51844"
FT DOMAIN 86..783
FT /note="Myosin motor"
FT /evidence="ECO:0000259|PROSITE:PS51456"
FT REGION 660..682
FT /note="Actin-binding"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
FT COILED 847..1928
FT /evidence="ECO:0000256|SAM:Coils"
FT BINDING 179..186
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
SQ SEQUENCE 1940 AA; 222941 MW; 721EBCDBF607EEBE CRC64;
MSADSEMAVF GEAAPYLRKS EKERIEAQNK PFDAKTSVFV AEPKESFVKG TIQSREGGKV
TVKTEGGATL TVKDDQIFPM NPPKFDKIED MAMMTHLHEP AVLYNLKERY AAWMIYTYSG
LFCVTVNPYK WLPVYNPEVV TAYRGKKRQE APPHIFSISD NAYQFMLTDR ENQSILITGE
SGAGKTVNTK RVIQYFATIA VTGDKKKEEV TSGKMQGTLE DQIISANPLL EAFGNAKTVR
NDNSSRFGKF IRIHFGATGK LASADIETYL LEKSRVTFQL KAERSYHIFY QIMSNKKPEL
IEMLLITTNP YDFAFVSQGE ITVPSIDDQE ELMATDSAVD ILGFTADEKV AIYKLTGAVM
HYGNMKFKQK QREEQAEPDG TEVADKAAYL QSLNSADLLK ALCYPRVKVG NEFVTKGQTV
QQVYNAVGAL AKAVYEKMFL WMVTRINQQL DTKQPRQYFI GVLDIAGFEI FDFNSLEQLC
INFTNEKLQQ FFNRHMFVLE QEEYKKEGIE WEFIDFGMDL AACIELIEKP MGIFSILEEE
CMFPKATDTS FKNKLYEQHL GKSNNFQKPR PTKGKAEAHF SLVHYAGTVD YNIAGWLDKN
KDPLNETVVG LYQKSALKTL AFLFAGGQSA EPEAGSGGKK GGKKKGSSFQ TVSALFRENL
NKLMTNLRST HPHFVRCLIP NETKTPGAME HELVLHQLRC NGVLEGIRIC RKGFPSRILY
ADFKQRYKVL NASAIPEGQF IDSKKASEKL LGSIDIDHTQ YKFGHTKVFF KAGLLGTLEE
MRDDKLAQLI THTQALCRGY LMRVEFKKMM ERRESVFCIQ YNIRAFMNVK HWPWMKLYFK
IKPLLKSAET EKEMATMKEE FEKTKEELAK SEAKRKELEE KMVALIQEKN DLQLQVQSEA
DGLADAEERC DQLIKTKIQL EVKIKELTER ADDEEEINAE LTAKKRKLED ECSELKKDID
DLELTLAKVE KEKHATENKV KNLTEEMAGL DETIAKLTKE KKALQEAHQQ TLDDLQAEED
KVNTLTKVKT KLEQQVDDLE GSLEQEKKLR MDLERAKRKL EGDLKLAQES TMDIENDKQQ
LDEKLKKKEF EMNNLQGRIE DEQVLGMQLQ KKIKELQARI EELEEEIEAE RASRAKAEKQ
RSDLSRELEE ISERLEEAGG ATSTQIELNK KREAEFQKMR RDLEEATLQH ETTAATLRKK
HADSVAELGE QIDNLQRVKQ KLEKEKSELK MEIDDLTSNM ETVSKAKGNL EKMCHTLEDQ
LSEVKSKEEE HQRLINELST QKARLHTESG ELSRQLDEKD ALVSQLSRGK QAYIQQVEEL
KRQLEEESKA KNALAHALQS AHHDCDLLRE QYEEEQEGKA ELQRAMSKAN SEVAQWRTKY
ETDAIQRTEE LEDAKKKLAQ RLQDAEEHVE AAIAKCASLE KTKQRLQNEV EDLMLDVERS
TAACAALEKK QRNFDKILSD WKQKYEETQA ELEASQKESR SLSTELFKVK NAYEESLDQL
ETLKRENKNL EQEISDLTEQ IAEGGKHIHE LEKVKKQIDQ EKSELQAALE EAEGSLEHEE
SKILRIQLEL NQVKSEIDQK IAEKDEEINQ LKRNHLRAVE SMQSTLDAEI RSRNDALRIK
KKMEGDLNEM EIQLNHANRQ AAEAIRNLRS TQGILKDTQL HLDDAIRGQD DLKEQLAMAE
RRANLMQAET EELRASLEQT ERSRKVAEQE LLDASERVQL LHTQNTGLLN TKKKLETDIS
QIQGEMEDVV QEARNAEEKA KKAITDAAMM AEELKKEQDT SAHLERMKKN LEQMAKDLQH
RLDEAEQLAL KGGKKQIQKL EARVRELENE VENEQKRNVE AVKGLRKHER RVKELAYQAE
EDRKNVLRLQ DLVDKLQTKV KVYKRQAEEA EEQSNVNLAK FRKLQHELEE AEERADIAES
QVNKLRMKSR EVHTKVKSEE
//
