ID G3THG7_LOXAF Unreviewed; 422 AA.
AC G3THG7;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 61.
DE RecName: Full=Hexosyltransferase {ECO:0000256|RuleBase:RU363063};
DE EC=2.4.1.- {ECO:0000256|RuleBase:RU363063};
GN Name=B3GALT2 {ECO:0000313|Ensembl:ENSLAFP00000014007.1};
OS Loxodonta africana (African elephant).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta.
OX NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000014007.1, ECO:0000313|Proteomes:UP000007646};
RN [1] {ECO:0000313|Ensembl:ENSLAFP00000014007.1, ECO:0000313|Proteomes:UP000007646}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000014007.1,
RC ECO:0000313|Proteomes:UP000007646};
RA Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Loxodonta africana (African elephant).";
RL Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLAFP00000014007.1}
RP IDENTIFICATION.
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000014007.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane
CC {ECO:0000256|RuleBase:RU363063}; Single-pass type II membrane protein
CC {ECO:0000256|RuleBase:RU363063}. Membrane
CC {ECO:0000256|ARBA:ARBA00004606}; Single-pass type II membrane protein
CC {ECO:0000256|ARBA:ARBA00004606}.
CC -!- SIMILARITY: Belongs to the glycosyltransferase 31 family.
CC {ECO:0000256|ARBA:ARBA00008661, ECO:0000256|RuleBase:RU363063}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_010589234.1; XM_010590932.1.
DR AlphaFoldDB; G3THG7; -.
DR STRING; 9785.ENSLAFP00000014007; -.
DR Ensembl; ENSLAFT00000016691.1; ENSLAFP00000014007.1; ENSLAFG00000016694.1.
DR eggNOG; KOG2287; Eukaryota.
DR GeneTree; ENSGT00940000155117; -.
DR HOGENOM; CLU_036849_2_1_1; -.
DR InParanoid; G3THG7; -.
DR OMA; TSYHFKY; -.
DR OrthoDB; 532757at2759; -.
DR TreeFam; TF318639; -.
DR Proteomes; UP000007646; Unassembled WGS sequence.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008499; F:UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity; IEA:Ensembl.
DR GO; GO:0006682; P:galactosylceramide biosynthetic process; IEA:Ensembl.
DR GO; GO:0009312; P:oligosaccharide biosynthetic process; IEA:Ensembl.
DR GO; GO:0006486; P:protein glycosylation; IEA:InterPro.
DR Gene3D; 3.90.550.50; -; 1.
DR InterPro; IPR045821; B3GT2_N.
DR InterPro; IPR002659; Glyco_trans_31.
DR PANTHER; PTHR11214:SF19; BETA-1,3-GALACTOSYLTRANSFERASE 2; 1.
DR PANTHER; PTHR11214; BETA-1,3-N-ACETYLGLUCOSAMINYLTRANSFERASE; 1.
DR Pfam; PF19341; B3GALT2_N; 1.
DR Pfam; PF01762; Galactosyl_T; 1.
PE 3: Inferred from homology;
KW Glycosyltransferase {ECO:0000256|RuleBase:RU363063};
KW Golgi apparatus {ECO:0000256|RuleBase:RU363063};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU363063};
KW Reference proteome {ECO:0000313|Proteomes:UP000007646};
KW Signal-anchor {ECO:0000256|ARBA:ARBA00022968,
KW ECO:0000256|RuleBase:RU363063};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU363063};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU363063}.
FT TRANSMEM 21..43
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363063"
FT DOMAIN 75..154
FT /note="Beta-1,3-galactosyltransferase 2 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF19341"
SQ SEQUENCE 422 AA; 49303 MW; C4E33508BB764004 CRC64;
MLQWRRRHCC FAKMTWNAKR SLFRTHLIGV LSLVFLFAMF LFFNHHDWLP GKAGFKENPV
TYTFRGFRST KSETNHSSLR NIWKETVPQT LRPQTATNYS NTDLSPQGVT GLENTLSANG
SIYNEKGTGH PNSYRFKYII NEPEKCQEKN PFLILLIAAE PGQIEARRAI RQTWGNESLA
PGIQITRIFL LGISIKLNGY LQHAILEESR QHHDIIQQEY LDTYYNLTIK TLMGMNWVAT
YCPHIPYVMK TDSDMFVNTE YLIHKLLKPD LPPRHNYFTG YLMRGYAPNR NKDSKWYMPP
DLYPSERYPV FCSGTGYVFS GDLAEKIFKV SLSIRRLHLE DVYVGICLAK LRIDPVPPPN
EFVFNHWRVS YSSCKYSHLI TSHQFQPSEL IKYWNHLQQN KHNACANAAK EKAARYRHRK
LH
//
