ID G3TIA8_LOXAF Unreviewed; 209 AA.
AC G3TIA8;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 55.
DE SubName: Full=Artemin {ECO:0000313|Ensembl:ENSLAFP00000014369.3};
GN Name=ARTN {ECO:0000313|Ensembl:ENSLAFP00000014369.3};
OS Loxodonta africana (African elephant).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta.
OX NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000014369.3, ECO:0000313|Proteomes:UP000007646};
RN [1] {ECO:0000313|Ensembl:ENSLAFP00000014369.3, ECO:0000313|Proteomes:UP000007646}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000014369.3,
RC ECO:0000313|Proteomes:UP000007646};
RA Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Loxodonta africana (African elephant).";
RL Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLAFP00000014369.3}
RP IDENTIFICATION.
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000014369.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the TGF-beta family. GDNF subfamily.
CC {ECO:0000256|ARBA:ARBA00009832}.
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DR AlphaFoldDB; G3TIA8; -.
DR STRING; 9785.ENSLAFP00000014369; -.
DR Ensembl; ENSLAFT00000017137.3; ENSLAFP00000014369.3; ENSLAFG00000017139.3.
DR eggNOG; ENOG502S53F; Eukaryota.
DR GeneTree; ENSGT00950000182993; -.
DR InParanoid; G3TIA8; -.
DR OMA; VTQPCCR; -.
DR TreeFam; TF332366; -.
DR Proteomes; UP000007646; Unassembled WGS sequence.
DR GO; GO:0005615; C:extracellular space; IEA:Ensembl.
DR GO; GO:0030116; F:glial cell-derived neurotrophic factor receptor binding; IEA:InterPro.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR GO; GO:0030971; F:receptor tyrosine kinase binding; IEA:InterPro.
DR GO; GO:0007411; P:axon guidance; IEA:Ensembl.
DR GO; GO:0050930; P:induction of positive chemotaxis; IEA:Ensembl.
DR GO; GO:0097021; P:lymphocyte migration into lymphoid organs; IEA:Ensembl.
DR GO; GO:0007422; P:peripheral nervous system development; IEA:Ensembl.
DR GO; GO:0061146; P:Peyer's patch morphogenesis; IEA:Ensembl.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR043401; GDNF_fam.
DR InterPro; IPR001839; TGF-b_C.
DR PANTHER; PTHR12173:SF9; ARTEMIN; 1.
DR PANTHER; PTHR12173; GDNF SUBFAMILY OF TGF-BETA FAMILY; 1.
DR Pfam; PF00019; TGF_beta; 1.
DR SMART; SM00204; TGFB; 1.
DR SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR PROSITE; PS51362; TGF_BETA_2; 1.
PE 3: Inferred from homology;
KW Growth factor {ECO:0000256|ARBA:ARBA00023030,
KW ECO:0000256|RuleBase:RU000354};
KW Reference proteome {ECO:0000313|Proteomes:UP000007646};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..32
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 33..209
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003455499"
FT DOMAIN 90..208
FT /note="TGF-beta family profile"
FT /evidence="ECO:0000259|PROSITE:PS51362"
FT REGION 35..108
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 70..86
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 209 AA; 21905 MW; 01D6E873930529B6 CRC64;
LFLTEALLWP SAQSPVWPTL AALALLSSVA ETSLDPASRS PATREGPAPA LASPAGHLQG
GRTARLCGGR PRRPPPPPPR PAPSLPAPAR GSRAARTGGR RSRARAAGAR GCRLRAQLVP
VRALGLGYSS DELVRFRFCS GSCRRARSPH DLSLASLLRA GVLRLPPGSR PVSQPCCRPT
SYEAVSFMDV NSTWRTVDSL SATACGCLG
//
