GenomeNet

Database: UniProt
Entry: G3TJP0_LOXAF
LinkDB: G3TJP0_LOXAF
Original site: G3TJP0_LOXAF 
ID   G3TJP0_LOXAF            Unreviewed;       841 AA.
AC   G3TJP0;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   07-JUN-2017, entry version 32.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
GN   Name=ATP6V0A4 {ECO:0000313|Ensembl:ENSLAFP00000014965};
OS   Loxodonta africana (African elephant).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta.
OX   NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000014965};
RN   [1] {ECO:0000313|Ensembl:ENSLAFP00000014965}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000014965};
RA   Di Palma F., Heiman D., Young S., Johnson J., Lander E.S.,
RA   Lindblad-Toh K.;
RT   "The Genome Sequence of Loxodonta africana (African elephant).";
RL   Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSLAFP00000014965}
RP   IDENTIFICATION.
RC   STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000014965};
RG   Ensembl;
RL   Submitted (SEP-2011) to UniProtKB.
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-
CC       ATPase), a multimeric enzyme that catalyzes the translocation of
CC       protons across the membranes. Required for assembly and activity
CC       of the V-ATPase. {ECO:0000256|RuleBase:RU361189}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|RuleBase:RU361189}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSLAFP00000014965}.
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DR   STRING; 9785.ENSLAFP00000014965; -.
DR   Ensembl; ENSLAFT00000017854; ENSLAFP00000014965; ENSLAFG00000017853.
DR   eggNOG; KOG2189; Eukaryota.
DR   eggNOG; COG1269; LUCA.
DR   GeneTree; ENSGT00390000004941; -.
DR   InParanoid; G3TJP0; -.
DR   OMA; FILRANH; -.
DR   OrthoDB; EOG091G01BI; -.
DR   TreeFam; TF300346; -.
DR   Proteomes; UP000007646; Unassembled WGS sequence.
DR   GO; GO:0016324; C:apical plasma membrane; IEA:Ensembl.
DR   GO; GO:0031526; C:brush border membrane; IEA:Ensembl.
DR   GO; GO:0005768; C:endosome; IEA:Ensembl.
DR   GO; GO:0070062; C:extracellular exosome; IEA:Ensembl.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005765; C:lysosomal membrane; IEA:Ensembl.
DR   GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR   GO; GO:0051117; F:ATPase binding; IEA:Ensembl.
DR   GO; GO:0015078; F:hydrogen ion transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0015991; P:ATP hydrolysis coupled proton transport; IEA:Ensembl.
DR   GO; GO:0007588; P:excretion; IEA:Ensembl.
DR   GO; GO:0001503; P:ossification; IEA:Ensembl.
DR   GO; GO:0006885; P:regulation of pH; IEA:Ensembl.
DR   GO; GO:0007605; P:sensory perception of sound; IEA:Ensembl.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR   PANTHER; PTHR11629; PTHR11629; 1.
DR   Pfam; PF01496; V_ATPase_I; 1.
DR   PIRSF; PIRSF001293; ATP6V0A1; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000007646};
KW   Hydrogen ion transport {ECO:0000256|RuleBase:RU361189};
KW   Ion transport {ECO:0000256|RuleBase:RU361189};
KW   Membrane {ECO:0000256|RuleBase:RU361189};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007646};
KW   Transmembrane {ECO:0000256|RuleBase:RU361189};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361189};
KW   Transport {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    403    427       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    447    466       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    545    566       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    572    596       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    642    662       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    773    797       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   COILED       93    120       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   841 AA;  96713 MW;  1DE2C5CD7BD7E967 CRC64;
     MASVFRSEEM CLSQLFLQVE AAYCCVAELG ELGLVQFKDL NMNVNSFQRK FVNEVRRCES
     LERILRFLED EMKNEIAIQV PEKYPPTPLP REMITLEIIL EKLERELQET NHNQQDLKKN
     FLQLMEFKHL LKKTEDFFEA ETNLADDFFM EDTSNLLELQ TSPAAMPGKL GFTTGVIDRE
     RMAAFERLMW RVCRGNIYLK FTEMDVSLEE PITKEEIKKN IFIIFYQGEQ LRQKIRKICD
     GFRATIYPCP EPAAERRGVL AEVNTRLEDL NIVITQTESH RQRLLQEVAA NWHSWAIQVQ
     KMKAIYHTLN LCNIDVTQQC LIAEVWFPVA DTAHIQRALE QGTEQSGSAM APILTTVPSK
     TAPPTFNRTN KFTAGFQNIV DAYGVGNYRE INPAPYTIIT FPFLFAVMFG DCGHGVVMLL
     AALWMVLNER ALLSQKSDNE IWNTFFYGRY LILLMGVFSI YTGLIYNDCF AKSFNIFGSS
     WSVRPMFRNG TWNSQVLETN TLLQLDPAVP GVYSGNPYPF GIDPVWNLAS NKLTFLNSYK
     MKMSVILGIV HMVFGVILSL FNHIFFRKVL NIILQFIPEM IFILCLFGYL VFMIIFKWCQ
     FDVHVSQDAP SILIHFINMF LFNYDDRANR PLYKHQQEVQ SFFVVMALIS VPWMLLIKPF
     ILRANHRKAQ VRTVGFHSLA GSRNVGCLEI EVHSHCHLSV ETCTAPEPPN EKTFFNFGDI
     FVHQAIHTIE YCLGCISNTA SYLRLWALSL AHAQLSEVLW TMVMNIGLRQ DGWGGLIAVF
     IIFAVFAVLT VAILLIMEGL SAFLHALRLH WVEFQNKFYV GAGYKFSPFS FKRILDGTAE
     E
//
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