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Database: UniProt
Entry: G3TKI4_LOXAF
LinkDB: G3TKI4_LOXAF
Original site: G3TKI4_LOXAF 
ID   G3TKI4_LOXAF            Unreviewed;       671 AA.
AC   G3TKI4;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   24-JAN-2024, entry version 65.
DE   RecName: Full=Signal recognition particle subunit SRP72 {ECO:0000256|ARBA:ARBA00018350, ECO:0000256|PIRNR:PIRNR038922};
GN   Name=SRP72 {ECO:0000313|Ensembl:ENSLAFP00000015338.3};
OS   Loxodonta africana (African elephant).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta.
OX   NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000015338.3, ECO:0000313|Proteomes:UP000007646};
RN   [1] {ECO:0000313|Ensembl:ENSLAFP00000015338.3, ECO:0000313|Proteomes:UP000007646}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000015338.3,
RC   ECO:0000313|Proteomes:UP000007646};
RA   Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., Lindblad-Toh K.;
RT   "The Genome Sequence of Loxodonta africana (African elephant).";
RL   Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSLAFP00000015338.3}
RP   IDENTIFICATION.
RC   STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000015338.3};
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
CC   -!- FUNCTION: Component of the signal recognition particle (SRP) complex, a
CC       ribonucleoprotein complex that mediates the cotranslational targeting
CC       of secretory and membrane proteins to the endoplasmic reticulum (ER).
CC       {ECO:0000256|PIRNR:PIRNR038922}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496,
CC       ECO:0000256|PIRNR:PIRNR038922}. Endoplasmic reticulum
CC       {ECO:0000256|ARBA:ARBA00004240}.
CC   -!- SIMILARITY: Belongs to the SRP72 family.
CC       {ECO:0000256|ARBA:ARBA00007676, ECO:0000256|PIRNR:PIRNR038922}.
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DR   RefSeq; XP_003415941.1; XM_003415893.2.
DR   AlphaFoldDB; G3TKI4; -.
DR   STRING; 9785.ENSLAFP00000015338; -.
DR   Ensembl; ENSLAFT00000018307.3; ENSLAFP00000015338.3; ENSLAFG00000018307.3.
DR   GeneID; 100658699; -.
DR   KEGG; lav:100658699; -.
DR   CTD; 6731; -.
DR   eggNOG; KOG2376; Eukaryota.
DR   GeneTree; ENSGT00390000013264; -.
DR   HOGENOM; CLU_013808_1_0_1; -.
DR   InParanoid; G3TKI4; -.
DR   OMA; NDMKVLA; -.
DR   OrthoDB; 91080at2759; -.
DR   TreeFam; TF106250; -.
DR   Proteomes; UP000007646; Unassembled WGS sequence.
DR   GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-KW.
DR   GO; GO:0005786; C:signal recognition particle, endoplasmic reticulum targeting; IEA:UniProtKB-UniRule.
DR   GO; GO:0008312; F:7S RNA binding; IEA:Ensembl.
DR   GO; GO:0043022; F:ribosome binding; IEA:Ensembl.
DR   GO; GO:0005047; F:signal recognition particle binding; IEA:Ensembl.
DR   GO; GO:0030911; F:TPR domain binding; IEA:Ensembl.
DR   GO; GO:0006614; P:SRP-dependent cotranslational protein targeting to membrane; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 4.
DR   InterPro; IPR013699; Signal_recog_part_SRP72_RNA-bd.
DR   InterPro; IPR026270; SRP72.
DR   InterPro; IPR031545; SRP72_TPR-like.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   InterPro; IPR019734; TPR_repeat.
DR   PANTHER; PTHR14094; SIGNAL RECOGNITION PARTICLE 72; 1.
DR   PANTHER; PTHR14094:SF9; SIGNAL RECOGNITION PARTICLE SUBUNIT SRP72; 1.
DR   Pfam; PF08492; SRP72; 1.
DR   Pfam; PF17004; SRP_TPR_like; 1.
DR   Pfam; PF13181; TPR_8; 2.
DR   PIRSF; PIRSF038922; SRP72; 1.
DR   SMART; SM00028; TPR; 5.
DR   SUPFAM; SSF48452; TPR-like; 2.
DR   PROSITE; PS50005; TPR; 1.
PE   3: Inferred from homology;
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|PIRNR:PIRNR038922};
KW   Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007646};
KW   Ribonucleoprotein {ECO:0000256|ARBA:ARBA00023274,
KW   ECO:0000256|PIRNR:PIRNR038922};
KW   Signal recognition particle {ECO:0000256|ARBA:ARBA00023135,
KW   ECO:0000256|PIRNR:PIRNR038922};
KW   TPR repeat {ECO:0000256|PROSITE-ProRule:PRU00339}.
FT   REPEAT          226..259
FT                   /note="TPR"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT   DOMAIN          532..588
FT                   /note="Signal recognition particle SRP72 subunit RNA-
FT                   binding"
FT                   /evidence="ECO:0000259|Pfam:PF08492"
FT   REGION          527..671
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        564..585
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        603..644
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        657..671
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   671 AA;  74608 MW;  7535B72FA82EF30F CRC64;
     MASGGSGGVS VPALWSEVNR YGQNGDFTRA LKTVNKILQI NKEDVTALHC KVVCLIQNGS
     FKEALNVINT HTKVLANNSL SFEKAYCEYR LNRIENALKT IESANQQTDK IKELYGQVLY
     RLERYDECLA VYRDLVRNSQ DDYDEERKTN LSAVVAAQSN WEKVVPENLG LQEGTHELCY
     NAACALIGQG QLNQAMKILQ KAEDLCRRSL SEDSDGTEED PQAELAIIHG QMAYILQLQG
     RTEEALQLYN QIIKLKPTDV GLLAVIANNI ITINKDQNVF DSKKKVKLTN AEGVEFKLSK
     KQLQAIEFNK ALLAMYTNQA EQCRKISSSL QSQSPEHLLP VLIQAAQLCR EKQHIKAIEL
     LQEFSDQHPE NAAEIKLTMA QLKISQGNIS KACLILRSIE ELKHKPGMVS ALVTMYSHEE
     DIDSAIEVFT QAIQWYQNHQ PKSSAHLSLI REAANFKLKY GRKKEAISDL EQLWKQNPKD
     IHTLAQLISA YSLVDPEKAK VLSNHLPSSD SMSLKVDVEA LENSPGATYI RKKGGKAAGD
     NQTKEQGQGD LKKKKKKKKG KLPKNYDPKV TPDPERWLPM RERSYYRGRK KGKKKDQIGK
     GTQGATAGAS SELDASKTVS SPPTSPRPGS AATVSASTSN IIPPRHQKPA GAPATKKKQQ
     QKKKKGGKGG W
//
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