ID   G3TKJ0_LOXAF            Unreviewed;       783 AA.
AC   G3TKJ0;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   27-MAR-2024, entry version 53.
DE   SubName: Full=BMP/retinoic acid inducible neural specific 2 {ECO:0000313|Ensembl:ENSLAFP00000015345.4};
GN   Name=BRINP2 {ECO:0000313|Ensembl:ENSLAFP00000015345.4};
OS   Loxodonta africana (African elephant).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta.
OX   NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000015345.4, ECO:0000313|Proteomes:UP000007646};
RN   [1] {ECO:0000313|Ensembl:ENSLAFP00000015345.4, ECO:0000313|Proteomes:UP000007646}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000015345.4,
RC   ECO:0000313|Proteomes:UP000007646};
RA   Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., Lindblad-Toh K.;
RT   "The Genome Sequence of Loxodonta africana (African elephant).";
RL   Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSLAFP00000015345.4}
RP   IDENTIFICATION.
RC   STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000015345.4};
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the BRINP family.
CC       {ECO:0000256|ARBA:ARBA00010360}.
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DR   RefSeq; XP_003410926.1; XM_003410878.2.
DR   AlphaFoldDB; G3TKJ0; -.
DR   STRING; 9785.ENSLAFP00000015345; -.
DR   Ensembl; ENSLAFT00000018315.4; ENSLAFP00000015345.4; ENSLAFG00000018314.4.
DR   GeneID; 100655445; -.
DR   KEGG; lav:100655445; -.
DR   CTD; 57795; -.
DR   eggNOG; ENOG502QQZS; Eukaryota.
DR   GeneTree; ENSGT00940000160314; -.
DR   HOGENOM; CLU_018347_0_0_1; -.
DR   InParanoid; G3TKJ0; -.
DR   OMA; LSACCRW; -.
DR   OrthoDB; 3949486at2759; -.
DR   TreeFam; TF331600; -.
DR   Proteomes; UP000007646; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0071300; P:cellular response to retinoic acid; IEA:Ensembl.
DR   GO; GO:0021953; P:central nervous system neuron differentiation; IEA:Ensembl.
DR   GO; GO:0045930; P:negative regulation of mitotic cell cycle; IEA:Ensembl.
DR   GO; GO:0045666; P:positive regulation of neuron differentiation; IEA:InterPro.
DR   InterPro; IPR033237; BRINP.
DR   InterPro; IPR020864; MACPF.
DR   PANTHER; PTHR15564:SF8; BMP_RETINOIC ACID-INDUCIBLE NEURAL-SPECIFIC PROTEIN 2; 1.
DR   PANTHER; PTHR15564; MACPF DOMAIN-CONTAINING PROTEIN; 1.
DR   Pfam; PF19052; BRINP; 1.
DR   Pfam; PF01823; MACPF; 1.
DR   SMART; SM00457; MACPF; 1.
PE   3: Inferred from homology;
KW   Cell cycle {ECO:0000256|ARBA:ARBA00022810};
KW   Growth arrest {ECO:0000256|ARBA:ARBA00022810};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007646};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        20..42
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          89..281
FT                   /note="MACPF"
FT                   /evidence="ECO:0000259|SMART:SM00457"
SQ   SEQUENCE   783 AA;  89039 MW;  F7C37B97A758D817 CRC64;
     MRWQCGTQFR GLQPATAPWA ILLALGLPGW VLVVSATAAA VVPEQHASSA GQPPLDWLLT
     DRGPFHRAQE YTDFMERYRQ GFTTRYRIYR EFARWKVNSL ALERKDFFSL PLPLAPEFVR
     NIRLLGRRPN LQQVTENLIK KYGTHFLLSA TLGGEESLTI FVDKRKLSRK TETGGGAPVA
     VGSGNSSAVS LETLHQLAAS YFIDRESTLR RLHHIQIATG AIKVTETRTG PLGCSNYDNL
     DSVSSVLVQS PENKVQLLGL QVLLPEYLRE RFVAAALSYI TCSSEGELIC KENDCWCKCG
     PTFPECNCPD ADIRAMEDGL LQIQDSWATH NRQFEESEEF QALLKRLPED RFLNSTAISH
     FWAMDNNLQH RYQQLGASLK VLFKKTHRIV RRLFSLCKRC HRQPRFRLPK ERPLSYWWNR
     IQSLLYCGES TFPGTFLEQS HSCTCPYDQS SCQGPIPCAL GEGPACAHCA PDNTTRCGSC
     NLGYVLAQGL CRPEVAESLE NFLGLETDLQ DLELKYLLQK RDSRIEVHSI FISNDMRLGS
     WFDPSWRKRM LLTLKSNKYK PGLVHVMLAL SLQICLTKNS TLEPVMAIYV NPFGGSHSES
     WFMPVNEGNF PDWERTNVDA AAQCQNWTIT LGNRWKTFFE TVHVYLRSRI KSLDDSSNET
     IYYEPLEMTD PSKNLGYMKI NTLQVFGYSL PFDPDAIRDL ILQLDYPYTQ GSQDSALLQL
     VELRDRVNQL SPPGKVRLDL FSCLLRHRLK LANNEVGRIQ SSLRAFNSKL PNPVEYETGK
     LCS
//