ID G3TLT9_LOXAF Unreviewed; 1910 AA.
AC G3TLT9;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 61.
DE SubName: Full=EMAP like 6 {ECO:0000313|Ensembl:ENSLAFP00000015938.3};
GN Name=EML6 {ECO:0000313|Ensembl:ENSLAFP00000015938.3};
OS Loxodonta africana (African elephant).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta.
OX NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000015938.3, ECO:0000313|Proteomes:UP000007646};
RN [1] {ECO:0000313|Ensembl:ENSLAFP00000015938.3, ECO:0000313|Proteomes:UP000007646}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000015938.3,
RC ECO:0000313|Proteomes:UP000007646};
RA Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Loxodonta africana (African elephant).";
RL Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLAFP00000015938.3}
RP IDENTIFICATION.
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000015938.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: May modify the assembly dynamics of microtubules, such that
CC microtubules are slightly longer, but more dynamic.
CC {ECO:0000256|ARBA:ARBA00003210}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}.
CC -!- SIMILARITY: Belongs to the WD repeat EMAP family.
CC {ECO:0000256|ARBA:ARBA00006489}.
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DR Ensembl; ENSLAFT00000020496.3; ENSLAFP00000015938.3; ENSLAFG00000020864.3.
DR GeneTree; ENSGT00940000155564; -.
DR HOGENOM; CLU_001930_0_0_1; -.
DR Proteomes; UP000007646; Unassembled WGS sequence.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 6.
DR InterPro; IPR024977; Apc4-like_WD40_dom.
DR InterPro; IPR011048; Haem_d1_sf.
DR InterPro; IPR005108; HELP.
DR InterPro; IPR011047; Quinoprotein_ADH-like_supfam.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR13720:SF52; ECHINODERM MICROTUBULE-ASSOCIATED PROTEIN-LIKE 6; 1.
DR PANTHER; PTHR13720; WD-40 REPEAT PROTEIN; 1.
DR Pfam; PF12894; ANAPC4_WD40; 1.
DR Pfam; PF03451; HELP; 2.
DR Pfam; PF00400; WD40; 10.
DR SMART; SM00320; WD40; 29.
DR SUPFAM; SSF51004; C-terminal (heme d1) domain of cytochrome cd1-nitrite reductase; 1.
DR SUPFAM; SSF50998; Quinoprotein alcohol dehydrogenase-like; 2.
DR SUPFAM; SSF50978; WD40 repeat-like; 2.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 7.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000007646};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT REPEAT 266..298
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 495..527
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT DOMAIN 604..651
FT /note="HELP"
FT /evidence="ECO:0000259|Pfam:PF03451"
FT REPEAT 950..971
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 1170..1202
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT DOMAIN 1285..1345
FT /note="HELP"
FT /evidence="ECO:0000259|Pfam:PF03451"
FT REPEAT 1642..1676
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT DOMAIN 1687..1764
FT /note="Anaphase-promoting complex subunit 4-like WD40"
FT /evidence="ECO:0000259|Pfam:PF12894"
FT REPEAT 1718..1759
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 1875..1910
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REGION 533..567
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 535..550
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 551..567
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1910 AA; 212002 MW; F0DD07A8037E5BF4 CRC64;
FSLALHPDKT LVATGQVGKE PYICVWDSYN VQTVSILKDV HTHGVACLAF DSDGQRLASV
GLDAKNTVCI WDWRKGKLLA SATGHSDRIF DISWDPYQPN RAVSCGVKHI KFWTLCGNAL
TAKRGIFGKT GDLQTILCLA CAKEDITYSG ALNGDIYVWK GLNLVRTIQG AHSAGIFSLY
ACEEGFATGG RDGCIRLWDT DFKPITKIDL RETEQGYKGL SIRSVCWKAD RLLAGTQDSE
IFEVIVRERD KPMLILQGHC EGELWALALH PKKPLAVTGS DDRSVRLWSL ADHALIARCN
MEEAVRSVAF SPDGSQLALG MKDGSFIVLR VRDMTEVVHI KDRKEVIHEM KFAPDGSYLA
VGSNDGPVDV YAVAQRYKKI GECSRSVSFI THIDWSLDSK YLQTNDGAGA RLFYRMPSGK
PLTSKEEIKG IPWASWTCVK GPEVSGIWPK YTDVTDINSV DANYDSSVLV SGDDFGLVKL
FKFPCLKKGA KFRKYVGHSA HVTNVRWSHD FQWVLSTGGA DHSVFQWRFI PEGVTNGTPE
TTPQEGGTDS YSEESDSDLS DVPELDSDIE QETQINYDRQ VYKEDLPQLK QQSKEKNQAV
PFLKREKAPE DSLRLQFIHG YRGYDCRNNL LYTQAGEVVY HIAAAAVVYD RQQHTQRLYL
GHDDDILSLT IHPVKDYVAT GQVGRDAAVH VWDTQTLKCL SLLKGQHQRG VCALDFSADG
KCLVSVGLDD FHSIVFWDWK KGEKIATTRG HKDKIFVIKC NPHHVDKLVT VGMKHIKFWQ
QAGGGFTSKR GIFGSVGKLE TMMCVSYGRM EDLVFSGAAT GDIFIWKDIL LLKTVKAHDG
PVFAMYALDK GFVTGGKDGI VELWDDMFER CLKTYAIKRA ALSTSSKGLL LEDNPSIRAI
TLGHGHILVG TKNGEILEID KSGPMTLLVQ GHMEGEVWGL AAHPLLPICA TVSDDKTLRI
WDLSSQHRML AVRKLKKGGR CCAFSPDGKA LAVGLNDGSF LVVNADTVED MVSFHHRKEM
ISDIKFSKDT GKYLAVASHD NFVDIYNVLT SKRVGICRGA SSYITHIDWD SRGKLLQVNS
GAKEQLFFEA PRGKRHIIRP SEIEKIEWDT WTCVLGPTCE GIWPAHSHVT DVNAASLTKD
CSLLATGDDF GFVKLFSYPV KGQHARFKKY VGHSAHVTNV RWLHNDSVLL TVGGADTALM
IWTREFVGTQ ESKLVDSEES DTDVEEDGGY DSDVAREKAI DYTTKIYAVS IREMEGTKPH
QQLKEVSMEE RYGVASGLQP PVSRAAPQPE KLQKNNVTKK KKLVEELALD HVFGYRGFDC
RNNLHYLNDG ADIIFHTAAA GVVQNLSTGS QSFYLEHTDD ILCLTVNQHP KYRNVVATSQ
IGRSCLPHPG TTPSIHIWDA MTKHTLSMLR CFHSKGVNYI NFSATGKLLV SVGVDPEHTI
TVWRWQEGAK VASRGGHLER IFVVEFRPDS DTQFVSVGVK HMKFWTLAGS ALLYKKGVTG
SMEAAKMQTM LSVAFGANNL TFTGAINGDV YVWKDHFLVR LVAKAHTGPV FTMYTTLRDG
LIVTGGKERP TKEGGAVKLW DQEMKRCRAF QLETGQLVEC VRSVCRGKGK ILVGTKDGEI
IEVGEKNAAS NILIDGHMEG EIWGLATHPS KDIFISASND GTARIWDLAD KKLLNKVNLG
HAARCAAYSP DGEMVAIGMK NGEFVILLVN SLKVWGKKRD RKSAIQDIRI SPDNRFLAVG
SSEHTVDFYD LTQGTSLNRT GYCKDIPSFV IQMDFSADSK YIQVSTGAYK RQVHEVPLGK
QVTDATVVEK ITWASWTSIL GDEVIGIWPR NADKADVNCA CVTHAGLNIV TGDDFGLVKL
FDFPCTEKFA KHKRYFGHSA HVTNIRFSHD DKYVVSTGGD DCSVFVWRCL
//
