ID G3TMV7_LOXAF Unreviewed; 1002 AA.
AC G3TMV7;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 60.
DE SubName: Full=Elastin microfibril interfacer 2 {ECO:0000313|Ensembl:ENSLAFP00000016491.2};
GN Name=EMILIN2 {ECO:0000313|Ensembl:ENSLAFP00000016491.2};
OS Loxodonta africana (African elephant).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta.
OX NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000016491.2, ECO:0000313|Proteomes:UP000007646};
RN [1] {ECO:0000313|Ensembl:ENSLAFP00000016491.2, ECO:0000313|Proteomes:UP000007646}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000016491.2,
RC ECO:0000313|Proteomes:UP000007646};
RA Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Loxodonta africana (African elephant).";
RL Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLAFP00000016491.2}
RP IDENTIFICATION.
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000016491.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR STRING; 9785.ENSLAFP00000016491; -.
DR Ensembl; ENSLAFT00000022270.2; ENSLAFP00000016491.2; ENSLAFG00000023146.2.
DR eggNOG; ENOG502QV5P; Eukaryota.
DR GeneTree; ENSGT01030000234633; -.
DR HOGENOM; CLU_011705_0_0_1; -.
DR InParanoid; G3TMV7; -.
DR OMA; PAWPGWT; -.
DR TreeFam; TF331033; -.
DR Proteomes; UP000007646; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:Ensembl.
DR GO; GO:0030336; P:negative regulation of cell migration; IEA:Ensembl.
DR GO; GO:0045766; P:positive regulation of angiogenesis; IEA:Ensembl.
DR GO; GO:0043065; P:positive regulation of apoptotic process; IEA:Ensembl.
DR GO; GO:0030194; P:positive regulation of blood coagulation; IEA:Ensembl.
DR GO; GO:1900426; P:positive regulation of defense response to bacterium; IEA:Ensembl.
DR GO; GO:1901731; P:positive regulation of platelet aggregation; IEA:Ensembl.
DR Gene3D; 2.60.120.40; -; 1.
DR InterPro; IPR001073; C1q_dom.
DR InterPro; IPR011489; EMI_domain.
DR InterPro; IPR008983; Tumour_necrosis_fac-like_dom.
DR PANTHER; PTHR15427; EMILIN ELASTIN MICROFIBRIL INTERFACE-LOCATED PROTEIN ELASTIN MICROFIBRIL INTERFACER; 1.
DR PANTHER; PTHR15427:SF5; EMILIN-2; 1.
DR Pfam; PF00386; C1q; 1.
DR Pfam; PF07546; EMI; 1.
DR SMART; SM00110; C1Q; 1.
DR SUPFAM; SSF49842; TNF-like; 1.
DR PROSITE; PS50871; C1Q; 1.
DR PROSITE; PS51041; EMI; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Reference proteome {ECO:0000313|Proteomes:UP000007646};
KW Signal {ECO:0000256|ARBA:ARBA00022729}.
FT DOMAIN 1..34
FT /note="EMI"
FT /evidence="ECO:0000259|PROSITE:PS51041"
FT DOMAIN 850..1001
FT /note="C1q"
FT /evidence="ECO:0000259|PROSITE:PS50871"
FT REGION 27..91
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 474..493
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 548..577
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 702..844
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 167..215
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 479..493
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 733..782
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1002 AA; 110097 MW; C31D9AAD90F3C560 CRC64;
YRVSFRPRYV TKFKTVTQLE WRCCPGFRGG DCQEGPGNPG RTPHPTPAQP RNSMKKATDN
EPNQIPGPKR TLAPTHTAEP SRVVDPKQGP QELQEKKIQV LEEKVFRLTR TVLDLQSSIA
GVNENLKHAI QNDAGKMLVS WLNNVHPQPT PDSAIGGDTE MVQLPGINNK ESGMKDIKSE
LAEVKDALKT KSDKLEELDG KVKGYEGQLK QLQEAAQGPT VTMTTNELYQ AYVDSKIDAL
REELMEGMDR KLADLKNSCE YRLVGLQQQC DDYGSSFLGV IELIGEKEAN LRKEINDLRA
QLPNPSIQTN CSDHEKNGAH FGQQIKMLDQ KIERVAEATR MLNGRLDNEF DRLTVPEPEV
DFVARWNELD ARINVTEKNA EEHCFYIEES LRGAINAEVH ELKQLLNQKI QSLEDRVGSV
LLEIANSSNA EFTPSSSTLP GVSGSGNEQV LTELNHLKDK LQVVEDICQQ NFQREPHGRE
GTLPNEEDHT MGDSSRLLKS LNDTMHRKFQ EIEWSIQKLQ QDFSFLYSQL NHTENNVTFL
QNEMSHCREG KNAEGGGFTK GGKPERTGET LPSPPDPTAQ CCSQLEEELQ RLQSQVLTGL
DTCKENMQGV QTEVSVVEGR VSQMEKTCNK LDSISGSLDK IKEGLNKHVS SLWSCIRQMN
GTLQSHSGDI SGLKNSVQQF YSHVFQISTD LQDLVKFQPS AIKSPXEVAQ PPPHRKGPQT
PGRLAKGPTK PAHPELTPAP LPRPSSLPPP EDPGQRPVLP KRPLSPQPPE EMLPPPAWPG
WTGLPLLPGS TGVIMETGEA GPPGRMGVSG RGLPQGVDGQ TGQAPFPNSE GYAGAPGYPK
SPPVASPGVL VPSLVSFSAG LTQKPFSSDG GVVLFNKVLV NDGDVYNPNT GIFTAPYDGR
YLITATLTPE RDTYVEAVLS VSNASVAQLH TAGYKREFLE YHQPPGALHT CGGLGAFHLI
VHLKAGDGVN IVVTGGRLAQ TDFDEMYSTF SGVLLYPFLS HL
//
