ID G3TQK1_LOXAF Unreviewed; 488 AA.
AC G3TQK1;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 63.
DE SubName: Full=CASP8 and FADD like apoptosis regulator {ECO:0000313|Ensembl:ENSLAFP00000017835.2};
GN Name=CFLAR {ECO:0000313|Ensembl:ENSLAFP00000017835.2};
OS Loxodonta africana (African elephant).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta.
OX NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000017835.2, ECO:0000313|Proteomes:UP000007646};
RN [1] {ECO:0000313|Ensembl:ENSLAFP00000017835.2, ECO:0000313|Proteomes:UP000007646}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000017835.2,
RC ECO:0000313|Proteomes:UP000007646};
RA Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Loxodonta africana (African elephant).";
RL Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLAFP00000017835.2}
RP IDENTIFICATION.
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000017835.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the peptidase C14A family.
CC {ECO:0000256|ARBA:ARBA00010134}.
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DR AlphaFoldDB; G3TQK1; -.
DR STRING; 9785.ENSLAFP00000017835; -.
DR MEROPS; C14.971; -.
DR Ensembl; ENSLAFT00000021995.2; ENSLAFP00000017835.2; ENSLAFG00000021855.2.
DR eggNOG; KOG3573; Eukaryota.
DR GeneTree; ENSGT00530000064199; -.
DR HOGENOM; CLU_036904_4_3_1; -.
DR InParanoid; G3TQK1; -.
DR OMA; NCFRSIH; -.
DR TreeFam; TF352765; -.
DR Proteomes; UP000007646; Unassembled WGS sequence.
DR GO; GO:0031264; C:death-inducing signaling complex; IEA:Ensembl.
DR GO; GO:0097342; C:ripoptosome; IEA:Ensembl.
DR GO; GO:0004197; F:cysteine-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0008047; F:enzyme activator activity; IEA:Ensembl.
DR GO; GO:0002020; F:protease binding; IEA:Ensembl.
DR GO; GO:0006915; P:apoptotic process; IEA:Ensembl.
DR GO; GO:1902042; P:negative regulation of extrinsic apoptotic signaling pathway via death domain receptors; IEA:Ensembl.
DR GO; GO:0043123; P:positive regulation of canonical NF-kappaB signal transduction; IEA:Ensembl.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR GO; GO:0060544; P:regulation of necroptotic process; IEA:Ensembl.
DR CDD; cd00032; CASc; 1.
DR CDD; cd08337; DED_c-FLIP_r1; 1.
DR CDD; cd08340; DED_c-FLIP_r2; 1.
DR Gene3D; 3.40.50.1460; -; 1.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 2.
DR InterPro; IPR029030; Caspase-like_dom_sf.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR001875; DED_dom.
DR InterPro; IPR011600; Pept_C14_caspase.
DR InterPro; IPR001309; Pept_C14_p20.
DR InterPro; IPR015917; Pept_C14A.
DR PANTHER; PTHR48169:SF4; CASP8 AND FADD LIKE APOPTOSIS REGULATOR; 1.
DR PANTHER; PTHR48169; DED DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF01335; DED; 2.
DR Pfam; PF00656; Peptidase_C14; 1.
DR PRINTS; PR00376; IL1BCENZYME.
DR SMART; SM00115; CASc; 1.
DR SMART; SM00031; DED; 2.
DR SUPFAM; SSF52129; Caspase-like; 1.
DR SUPFAM; SSF47986; DEATH domain; 2.
DR PROSITE; PS50208; CASPASE_P20; 1.
DR PROSITE; PS50168; DED; 2.
PE 3: Inferred from homology;
KW Apoptosis {ECO:0000256|ARBA:ARBA00022703};
KW Reference proteome {ECO:0000313|Proteomes:UP000007646};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 6..78
FT /note="DED"
FT /evidence="ECO:0000259|PROSITE:PS50168"
FT DOMAIN 97..175
FT /note="DED"
FT /evidence="ECO:0000259|PROSITE:PS50168"
FT DOMAIN 271..366
FT /note="Caspase family p20"
FT /evidence="ECO:0000259|PROSITE:PS50208"
SQ SEQUENCE 488 AA; 55649 MW; 717EF1E54CD0EF3A CRC64;
MTRCGVPAAV IHQVEEALDE DEKEMLLFLC RDVARDVALP NVRDLLDILS ERGKLSAMGL
AELLYRMRRF DLLKRILKMD KAAVEALLLR DPHLVSDYRV LLTEISEDLD KSDVSSLIFL
LRDYTGRGKI AKDKSFLDLV VELEKQNLVA PDQLDLLEKC LKNIHRIDLK TKIQKYKQSA
QGAAGTKYVN ALQASLPNLS LKEPTYNLGL QNGRNKEQRM VAGQLGIQRE RVKTSVQESG
VFLSQHIPEE RYRMQSKPLG ICLIIDCIGN DIELLRDTFT SLGFEVQYFL HLHMENIIQI
LHQVACMPQH QNYDSFVCVL VSRGGSQSVF GVDQTHRGYS LDHIRRIFMG DLCPSLLGKP
KLFFIQIYVV SEDQQEVSSL LEMDGAGVNS VDSKARQPGP CMVHREADFL WSLCRADVAL
LEQSSSSPSV YLQCLSQKLQ QERKRPLLDL HIELHSKVYD WNSRVSAKEK YSVWLQHTLR
KKLILSCK
//
