ID G3TQK6_LOXAF Unreviewed; 272 AA.
AC G3TQK6;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 66.
DE RecName: Full=Collectin-11 {ECO:0000256|ARBA:ARBA00040130};
GN Name=COLEC11 {ECO:0000313|Ensembl:ENSLAFP00000017842.2};
OS Loxodonta africana (African elephant).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta.
OX NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000017842.2, ECO:0000313|Proteomes:UP000007646};
RN [1] {ECO:0000313|Ensembl:ENSLAFP00000017842.2, ECO:0000313|Proteomes:UP000007646}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000017842.2,
RC ECO:0000313|Proteomes:UP000007646};
RA Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Loxodonta africana (African elephant).";
RL Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLAFP00000017842.2}
RP IDENTIFICATION.
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000017842.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the COLEC10/COLEC11 family.
CC {ECO:0000256|ARBA:ARBA00038195}.
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DR AlphaFoldDB; G3TQK6; -.
DR STRING; 9785.ENSLAFP00000017842; -.
DR Ensembl; ENSLAFT00000021679.2; ENSLAFP00000017842.2; ENSLAFG00000021841.2.
DR eggNOG; KOG4297; Eukaryota.
DR GeneTree; ENSGT00940000159468; -.
DR HOGENOM; CLU_049894_3_2_1; -.
DR InParanoid; G3TQK6; -.
DR OMA; ITMYFLC; -.
DR TreeFam; TF330481; -.
DR Proteomes; UP000007646; Unassembled WGS sequence.
DR GO; GO:0005581; C:collagen trimer; IEA:UniProtKB-KW.
DR GO; GO:0005615; C:extracellular space; IEA:Ensembl.
DR GO; GO:0005509; F:calcium ion binding; IEA:Ensembl.
DR GO; GO:0120153; F:calcium-dependent carbohydrate binding; IEA:Ensembl.
DR GO; GO:0003677; F:DNA binding; IEA:Ensembl.
DR GO; GO:0042806; F:fucose binding; IEA:Ensembl.
DR GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR GO; GO:0005537; F:mannose binding; IEA:UniProtKB-KW.
DR GO; GO:0070492; F:oligosaccharide binding; IEA:Ensembl.
DR GO; GO:0019730; P:antimicrobial humoral response; IEA:Ensembl.
DR GO; GO:0001867; P:complement activation, lectin pathway; IEA:Ensembl.
DR GO; GO:1903028; P:positive regulation of opsonization; IEA:Ensembl.
DR GO; GO:0006508; P:proteolysis; IEA:Ensembl.
DR CDD; cd03591; CLECT_collectin_like; 1.
DR Gene3D; 3.10.100.10; Mannose-Binding Protein A, subunit A; 1.
DR InterPro; IPR001304; C-type_lectin-like.
DR InterPro; IPR016186; C-type_lectin-like/link_sf.
DR InterPro; IPR018378; C-type_lectin_CS.
DR InterPro; IPR008160; Collagen.
DR InterPro; IPR033990; Collectin_CTLD.
DR InterPro; IPR016187; CTDL_fold.
DR PANTHER; PTHR22801:SF60; COLLECTIN SUBFAMILY MEMBER 11; 1.
DR PANTHER; PTHR22801; LITHOSTATHINE; 1.
DR Pfam; PF01391; Collagen; 2.
DR Pfam; PF00059; Lectin_C; 1.
DR SMART; SM00034; CLECT; 1.
DR SUPFAM; SSF56436; C-type lectin-like; 1.
DR PROSITE; PS00615; C_TYPE_LECTIN_1; 1.
DR PROSITE; PS50041; C_TYPE_LECTIN_2; 1.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Collagen {ECO:0000256|ARBA:ARBA00023119};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Lectin {ECO:0000256|ARBA:ARBA00022734};
KW Reference proteome {ECO:0000313|Proteomes:UP000007646};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..272
FT /note="Collectin-11"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003455661"
FT DOMAIN 150..266
FT /note="C-type lectin"
FT /evidence="ECO:0000259|PROSITE:PS50041"
FT REGION 45..112
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 272 AA; 29296 MW; 376D9950AD7B15E3 CRC64;
IMKRDLAFLG TLISLGFLSL LRSGYPQQTA EEACSMQILV PGLKGDAGEK GEKGAPGRPG
RVGPTGEKGD MGDKGQKGSV GRHGKIGPIG SKGEKGDSGD IGPPGLSGEP GIPCECSQLR
KAIGEMDNQV TQLTTELKFI KNAVAGVRET DNKIYLLVKE EKRYVDAQLS CQGRGGMLSM
PKDETSNGLI ASYITQAGLT RVFIGINDLE KEGTFVYSDR SPMQTFSKWR NGEPNNAYDE
EDCVEMVASG GWNDVACHIT MYFICEFDKE NV
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