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Database: UniProt
Entry: G3TRA8_LOXAF
LinkDB: G3TRA8_LOXAF
Original site: G3TRA8_LOXAF 
ID   G3TRA8_LOXAF            Unreviewed;       877 AA.
AC   G3TRA8;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   27-SEP-2017, entry version 34.
DE   SubName: Full=Transient receptor potential cation channel subfamily C member 6 {ECO:0000313|Ensembl:ENSLAFP00000018116};
GN   Name=TRPC6 {ECO:0000313|Ensembl:ENSLAFP00000018116};
OS   Loxodonta africana (African elephant).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta.
OX   NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000018116, ECO:0000313|Proteomes:UP000007646};
RN   [1] {ECO:0000313|Ensembl:ENSLAFP00000018116}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000018116};
RA   Di Palma F., Heiman D., Young S., Johnson J., Lander E.S.,
RA   Lindblad-Toh K.;
RT   "The Genome Sequence of Loxodonta africana (African elephant).";
RL   Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSLAFP00000018116}
RP   IDENTIFICATION.
RC   STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000018116};
RG   Ensembl;
RL   Submitted (SEP-2011) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the transient receptor (TC 1.A.4) family.
CC       {ECO:0000256|SAAS:SAAS00788929}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSLAFP00000018116}.
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DR   Ensembl; ENSLAFT00000035539; ENSLAFP00000018116; ENSLAFG00000015085.
DR   eggNOG; KOG3609; Eukaryota.
DR   eggNOG; ENOG410XQ0Y; LUCA.
DR   GeneTree; ENSGT00760000119180; -.
DR   Proteomes; UP000007646; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005262; F:calcium channel activity; IEA:InterPro.
DR   CDD; cd00204; ANK; 1.
DR   Gene3D; 1.25.40.20; -; 1.
DR   InterPro; IPR002110; Ankyrin_rpt.
DR   InterPro; IPR020683; Ankyrin_rpt-contain_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR004729; TRP_channel.
DR   InterPro; IPR013555; TRP_dom.
DR   InterPro; IPR005462; TRPC6_channel.
DR   InterPro; IPR002153; TRPC_channel.
DR   PANTHER; PTHR10117; PTHR10117; 1.
DR   PANTHER; PTHR10117:SF69; PTHR10117:SF69; 1.
DR   Pfam; PF12796; Ank_2; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF08344; TRP_2; 1.
DR   PRINTS; PR01097; TRNSRECEPTRP.
DR   PRINTS; PR01647; TRPCHANNEL6.
DR   SMART; SM00248; ANK; 3.
DR   SUPFAM; SSF48403; SSF48403; 1.
DR   TIGRFAMs; TIGR00870; trp; 1.
DR   PROSITE; PS50297; ANK_REP_REGION; 2.
DR   PROSITE; PS50088; ANK_REPEAT; 1.
PE   3: Inferred from homology;
KW   ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023,
KW   ECO:0000256|SAAS:SAAS00844120}; Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000007646};
KW   Ion channel {ECO:0000256|SAAS:SAAS00816195};
KW   Ion transport {ECO:0000256|SAAS:SAAS00816776};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007646};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|SAAS:SAAS00816535}.
FT   TRANSMEM    353    373       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    385    405       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    436    454       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    474    493       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    539    560       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    580    602       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    649    670       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       50    100       ANK_REP_REGION. {ECO:0000259|PROSITE:
FT                                PS50297}.
FT   REPEAT      163    195       ANK. {ECO:0000256|PROSITE-ProRule:
FT                                PRU00023}.
FT   DOMAIN      163    195       ANK_REP_REGION. {ECO:0000259|PROSITE:
FT                                PS50297}.
FT   COILED      830    865       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   877 AA;  100711 MW;  37DF68B24E06F2E0 CRC64;
     CSRGTDNRLA HRRQTILREK GRRLANRGPA YMFSDRSTSL SIEEERFLDA AEYGNVPVVR
     KMLEECLSLN VNCVDYMGQN ALQLAVANEH LEITELLLKK ENLSRVGDAL LLAISKGYVR
     IVEAILGHPA FAEGKRLATS PSQSELQQDD FYAYDEDGTR FSHDVTPIIL AAHCQEYEIV
     HTLLRKGARI ERPHDYFCKC GECNQKQKHD SFSHSRSRIN AYKGLASPAY LSLSSEDPVM
     TALVLSNELA VLANIEKEFK NDYKKLSMQC KDFVVGLLDL CRNTEEVEAI LNGDVEMRHN
     GGDHGRPNLS RLKLAIKYEV KKFVAHPNCQ QQLLSIWYEN LSGLRQQTMA VKFLVVLAVA
     IGLPFLALIY WFAPCSKMGK IMRGPFMKFV AHAASFTIFL GLLVMNAADR FEGTKLLPNE
     TSTDNAKQLF RMKTSCFSWM EMLIISWVIG MIWAECKEIW TQGPKEYLFE LWNMLDFGML
     AIFAASFIAR FMAFWHASKA QSIIDANDTL KDLTKVTLGD NVKYYNLARI KWDPSDPQII
     SEGLYAIAVV LSFSRIAYIL PANESFGPLQ ISLGRTVKDI FKFMVIFIMV FVAFMIGMFN
     LYSYYRGAKQ NEAFTTVEES FKTLFWAIFG LSEVKSVVIN YNHKFIENIG YVLYGVYNVT
     MVIVLLNMLI AMINSSFQEI EDDADVEWKF ARAKLWFSYF EEGRTLPVPF NLVPSPKSLF
     YLLLKLKKWI SELFQGHKKG FQEDAEMNKN NNKTHWGIYT SFQSLNCFSN PKNQLEHSKQ
     SSIRSSEDFH LNSFNNPPRQ YQKIMKRLIK RYVLKAQIDK ESDEVNEGEL KEIKQDISSL
     RYELLEEKSQ NTEDLAELIR KLGEKLSMEP NQEENNR
//
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