ID G3TSH8_LOXAF Unreviewed; 808 AA.
AC G3TSH8;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 75.
DE SubName: Full=Toll like receptor 10 {ECO:0000313|Ensembl:ENSLAFP00000018536.1};
GN Name=TLR10 {ECO:0000313|Ensembl:ENSLAFP00000018536.1};
OS Loxodonta africana (African elephant).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta.
OX NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000018536.1, ECO:0000313|Proteomes:UP000007646};
RN [1] {ECO:0000313|Ensembl:ENSLAFP00000018536.1, ECO:0000313|Proteomes:UP000007646}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000018536.1,
RC ECO:0000313|Proteomes:UP000007646};
RA Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Loxodonta africana (African elephant).";
RL Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLAFP00000018536.1}
RP IDENTIFICATION.
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000018536.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the Toll-like receptor family.
CC {ECO:0000256|ARBA:ARBA00009634, ECO:0000256|PIRNR:PIRNR037595}.
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DR AlphaFoldDB; G3TSH8; -.
DR STRING; 9785.ENSLAFP00000018536; -.
DR Ensembl; ENSLAFT00000008544.3; ENSLAFP00000018536.1; ENSLAFG00000008544.3.
DR eggNOG; KOG4641; Eukaryota.
DR GeneTree; ENSGT00940000163662; -.
DR HOGENOM; CLU_006000_3_0_1; -.
DR InParanoid; G3TSH8; -.
DR OMA; ICLYERY; -.
DR TreeFam; TF351113; -.
DR Proteomes; UP000007646; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0043235; C:receptor complex; IEA:Ensembl.
DR GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-UniRule.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-UniRule.
DR GO; GO:0002224; P:toll-like receptor signaling pathway; IEA:InterPro.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR InterPro; IPR000483; Cys-rich_flank_reg_C.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR017241; Toll-like_receptor.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR PANTHER; PTHR24365; TOLL-LIKE RECEPTOR; 1.
DR PANTHER; PTHR24365:SF23; TOLL-LIKE RECEPTOR 10; 1.
DR Pfam; PF13855; LRR_8; 1.
DR Pfam; PF01582; TIR; 1.
DR PIRSF; PIRSF037595; Toll-like_receptor; 1.
DR SMART; SM00369; LRR_TYP; 5.
DR SMART; SM00082; LRRCT; 1.
DR SMART; SM00255; TIR; 1.
DR SUPFAM; SSF52058; L domain-like; 1.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR PROSITE; PS50104; TIR; 1.
PE 3: Inferred from homology;
KW Immunity {ECO:0000256|ARBA:ARBA00022859, ECO:0000256|PIRNR:PIRNR037595};
KW Inflammatory response {ECO:0000256|ARBA:ARBA00023198,
KW ECO:0000256|PIRNR:PIRNR037595};
KW Innate immunity {ECO:0000256|ARBA:ARBA00022588,
KW ECO:0000256|PIRNR:PIRNR037595};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|PIRNR:PIRNR037595};
KW Reference proteome {ECO:0000313|Proteomes:UP000007646};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..808
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003455446"
FT TRANSMEM 577..606
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 631..772
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
SQ SEQUENCE 808 AA; 93862 MW; 9C9C2AE6A31BC688 CRC64;
VRLLRNTCIF CSIVISAQGW TPKQPEEGEL TTNCSSMSLR RVPEDLTPTT TTLDLSYNLL
FQIQSSDFRS VSNLKILILC HNRIQQLDIK AFEFNKELRY LDLSHNRLKI VTCYSLPGLR
HLDLSFNDFD TVPICEETGN MSHLEILGLS GAKIQKSDFQ KIAHLYLNTV ILGLRTLSYY
EEGSLPILNT TKLHMVLPKN INFWVLLCDG IKTSKILEMT NIDDKSQFAS NETQRNLRLK
NAKTSILLLN EVDLLWDDLL IIFQLVWHTS VEYFQLQNVA FGGNVYLDHN SFDYSNTVMR
AIKLEHVHFR IFYIPQDRVY LLFTKMDIEN LTISDAQMPH MIFPNYPMRF QYLNFANNVL
TDALFKKPIH LPHLKTLILK GNQLETFFLV SHFASNTSLQ HLDLSQNLLQ HENNENCSWP
ETLITMNLSS NKFPDSVFRC LPRSIQILDL NNNKIQTVPK AITHLKSLRE LNVAFNFLTD
LPGCSHFRSL SILNIEMNLI LSPSREFFQS CREVKILNAG RNPFRCTCEL RDFIQLQKNS
EGMLAGWSDS YICEYPLNLK GTQLKDVHLP ELSCNTALLI VIIVVMLSLG MTVAFCCLHF
DLLWYIRMLS QWTQTWNRVR KTAQERLKRN VQFHAFISYS EHDSPWVKNE LIPNLEKEDG
SVLICLHERN FDPGKSVTEN IINCIEKSYT SILVLSPNFV QSEWCHYELY FAHHNLVHEN
YIILILLEHI PLYCIPNRYH KLKALMEEKT CLKWPKDRRK HGLFWANLRA AINISLSETR
DMCELQTFAE LNEESRGSTD SLIKTDCL
//
