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Database: UniProt
Entry: G3TU82_LOXAF
LinkDB: G3TU82_LOXAF
Original site: G3TU82_LOXAF 
ID   G3TU82_LOXAF            Unreviewed;       692 AA.
AC   G3TU82;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   25-OCT-2017, entry version 42.
DE   SubName: Full=Hyperpolarization activated cyclic nucleotide gated potassium channel 3 {ECO:0000313|Ensembl:ENSLAFP00000019140};
GN   Name=HCN3 {ECO:0000313|Ensembl:ENSLAFP00000019140};
OS   Loxodonta africana (African elephant).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta.
OX   NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000019140};
RN   [1] {ECO:0000313|Ensembl:ENSLAFP00000019140}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000019140};
RA   Di Palma F., Heiman D., Young S., Johnson J., Lander E.S.,
RA   Lindblad-Toh K.;
RT   "The Genome Sequence of Loxodonta africana (African elephant).";
RL   Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSLAFP00000019140}
RP   IDENTIFICATION.
RC   STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000019140};
RG   Ensembl;
RL   Submitted (SEP-2011) to UniProtKB.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSLAFP00000019140}.
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DR   STRING; 9785.ENSLAFP00000019140; -.
DR   Ensembl; ENSLAFT00000032009; ENSLAFP00000019140; ENSLAFG00000003265.
DR   eggNOG; KOG0498; Eukaryota.
DR   eggNOG; ENOG410XPSE; LUCA.
DR   GeneTree; ENSGT00900000140801; -.
DR   InParanoid; G3TU82; -.
DR   OMA; VMEQHLV; -.
DR   OrthoDB; EOG091G0JQU; -.
DR   TreeFam; TF318250; -.
DR   Proteomes; UP000007646; Unassembled WGS sequence.
DR   GO; GO:0005887; C:integral component of plasma membrane; IEA:Ensembl.
DR   GO; GO:0005249; F:voltage-gated potassium channel activity; IEA:Ensembl.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:Ensembl.
DR   CDD; cd00038; CAP_ED; 1.
DR   Gene3D; 2.60.120.10; -; 1.
DR   InterPro; IPR018490; cNMP-bd-like.
DR   InterPro; IPR000595; cNMP-bd_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR003938; K_chnl_volt-dep_EAG/ELK/ERG.
DR   InterPro; IPR014710; RmlC-like_jellyroll.
DR   Pfam; PF00027; cNMP_binding; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   PRINTS; PR01463; EAGCHANLFMLY.
DR   SMART; SM00100; cNMP; 1.
DR   SUPFAM; SSF51206; SSF51206; 1.
DR   PROSITE; PS50042; CNMP_BINDING_3; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000007646};
KW   Ion channel {ECO:0000256|SAAS:SAAS00904115};
KW   Ion transport {ECO:0000256|SAAS:SAAS00502700};
KW   Membrane {ECO:0000256|SAAS:SAAS00502630, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007646};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00137614,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00137754,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|SAAS:SAAS00502637}.
FT   TRANSMEM      7     31       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      340    446       Cyclic nucleotide-binding.
FT                                {ECO:0000259|PROSITE:PS50042}.
SQ   SEQUENCE   692 AA;  77246 MW;  61206F9D2AF01B11 CRC64;
     PYSDFRFYWD LTMLLLMVGN LIVLPVGITF FKEENSPPWI VFNVLSDTFF LLDLVLNFRT
     GIVVEEGAEI LLAPRAIRTR YLRTWFLVDL ISSIPVDYIF LVVELEPRLD AEVYKTARAL
     RIVRFTKILS LLRLLRLSRL IRYIHQWEIF HMTYDLASAV VRIFNLIGMM LLLCHWDGCL
     QFLVPMLQDF PPDCWVSINH MVNHSWGRQY SHALFKAMSH MLCIGYGQQA PVGMPDVWLT
     MLSMIVGATC YAMFIGHATA LIQSLDSSRR QYQEKYKQVE QYMSFHKLPA DTRQRIHEYY
     EHRYQGKMFD EESILGELSE PLREEIINFT CRGLVAHMPL FAHADPSFVT AVLTKLRFEV
     FQPGDLVVRE GSVGRKMYFI QHGLLSVLAR GARDTRLTDG SYFGEICLLT RGRRTASVRA
     DTYCRLYSLS VDHFNAVLEE FPMMRRAFET VAVDRLRRIG KKNSLLQRKR SEPSPGSSGG
     IMEQHLVQHD RDMARGVRGL APGTGARLSG KPVLWEPLVH APLQAAAVTS NVAIALTHQR
     GPLSLSPDSP ATLLARSARR SAGSPASPLV PVRAAPLLVR GPWASTSRLP APPARTLHAS
     LSRAGRSQVS LLGPPPGGGG RRLGPRGRPL SASQPSLPQR AAGDGSPGRK GSGNERLPPS
     GLLAKPPGTA QSPRPPVPEP AAPRGPQLSA NM
//
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