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Database: UniProt
Entry: G3TVK8_LOXAF
LinkDB: G3TVK8_LOXAF
Original site: G3TVK8_LOXAF 
ID   G3TVK8_LOXAF            Unreviewed;      1781 AA.
AC   G3TVK8;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   10-MAY-2017, entry version 35.
DE   RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
GN   Name=SCN10A {ECO:0000313|Ensembl:ENSLAFP00000019616};
OS   Loxodonta africana (African elephant).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta.
OX   NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000019616};
RN   [1] {ECO:0000313|Ensembl:ENSLAFP00000019616}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000019616};
RA   Di Palma F., Heiman D., Young S., Johnson J., Lander E.S.,
RA   Lindblad-Toh K.;
RT   "The Genome Sequence of Loxodonta africana (African elephant).";
RL   Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSLAFP00000019616}
RP   IDENTIFICATION.
RC   STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000019616};
RG   Ensembl;
RL   Submitted (SEP-2011) to UniProtKB.
CC   -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability
CC       of excitable membranes. {ECO:0000256|RuleBase:RU361132}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSLAFP00000019616}.
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DR   Ensembl; ENSLAFT00000030605; ENSLAFP00000019616; ENSLAFG00000003408.
DR   GeneTree; ENSGT00830000128242; -.
DR   Proteomes; UP000007646; Unassembled WGS sequence.
DR   GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:InterPro.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR028821; Na_channel_a11su.
DR   InterPro; IPR001696; Na_channel_asu.
DR   InterPro; IPR010526; Na_trans_assoc.
DR   PANTHER; PTHR10037:SF229; PTHR10037:SF229; 1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   Pfam; PF06512; Na_trans_assoc; 1.
DR   PRINTS; PR00170; NACHANNEL.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000007646};
KW   Ion channel {ECO:0000256|RuleBase:RU361132};
KW   Ion transport {ECO:0000256|RuleBase:RU361132};
KW   Membrane {ECO:0000256|RuleBase:RU361132};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007646};
KW   Sodium {ECO:0000256|RuleBase:RU361132};
KW   Sodium channel {ECO:0000256|RuleBase:RU361132};
KW   Sodium transport {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361132};
KW   Transport {ECO:0000256|RuleBase:RU361132};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    107    127       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    133    154       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    166    185       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    205    223       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    235    255       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    261    281       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    375    396       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    582    600       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    612    633       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    645    663       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    701    724       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    781    807       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1052   1070       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1091   1110       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1116   1135       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1161   1187       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1282   1305       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1355   1378       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1398   1416       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1428   1446       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1483   1511       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1531   1550       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1571   1597       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   DOMAIN      134    413       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      582    816       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      825   1046       Na_trans_assoc. {ECO:0000259|Pfam:
FT                                PF06512}.
FT   DOMAIN     1050   1314       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1363   1611       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   COILED      407    438       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1781 AA;  203757 MW;  A675D47115D0D546 CRC64;
     MDDRFYTIIF PDERNFRPFT PDSLAAINKR IAIEKERKKS KDQTATEPKL RPQLDLKVSR
     KLPKLYGDIP PELVAKPLED LDPYYRNHKT FMVLNKKRTI YRFSAKHALF VFGPFNPIRS
     LAIRVLIHSY PFTTVFSVFI ICTVTVNCVF MASIPAKHNS GNDSNIPEYV FTGIYIFEAL
     IKILARGFVL DEFSFLRDPW NWLDSIVIAT AFASYFPATK ISLSSLRTFR VFRALKAISV
     VSGLKVIVGA LLRSVKKLVD VMILTLFCLS IFALVGQQLF MGSLNQKCVR KDCLNGTLFE
     GNCFEKKAST NDKSNCYLSL GVSSSCSEQF TCSHTKYNPD YDYTNFDSFG WSVLAMFRLM
     TQDSWERLYR QVLHVTGYFS VFFFVVVIFL GSFYLINLTL AVVTMAYEEQ NRNVAAETEA
     KEKLFQEAQK LLQEEKEALV AMGIDRSSLT SLEASSFVPK KRKLFGSRKR KPSFLRESGK
     DQAPGSDSDE DSKKKPRLLE QTKRLSQNLS VDHFDENRDP SQRQRALSAV SILTITIQEQ
     EKSQEPCLSC GESLASKYLV WDCSPQWLRI KKVLRTVVTD PFTELAITIC IIVNTVFLAL
     EHRRMKEDFK DMLATGNKVF SGIFIAEVCL KIIALDPYHY FHGGWNVFDF VVALLSLADV
     LTFDKSIPVL RSFRVLRVFK LAKSWPTLNT LIKIIGHSVG ALGNLTVVLA IVVFIFSVVG
     MHLFGAQFNS TRTKQPCSSK APCQRRWHME NFYHSFLVVF RILCGEWIES MWECLQETGS
     YLCVFVFLLI MVIGKLVVLN LFIALLLNSF SNEERDGNSE EGAKKTKVQL ALSRFHQAFC
     FVMHTVRHFF CHWCRRPNLP RQKELIGSPA SRSKDIIPLV VETKIGPETG EEFGALTSPR
     KAIDDGYERT RLAPLAEEEY DIESPDEDNV HPDTQPETAK QVGRLTPKTL KSSSPEVQSV
     EIDVFPEDEQ ATVHNPRKKS DATSVLSYCS TIDPVDPFRW LPEMVPKKQP ERCLPKGLGH
     CFPRCGMDKG RPLWVTWWKL RKTCYQIVKH SWFESFVIFV ILLSSGMLVF EDIHLKEQPK
     IQALLNCTDS IFTYIFILEM GLKWVAFGFS KYFTSAWCWL DFIIVIVSVT SLIDLKPLKS
     FRTLRALRPL RALSQFEGMK VVVNALIGAI PAILNVLLVC LIFWLIFCIL GVSLFCGKFE
     RCINKTDMNS VIDYEIIANK SQCVSKNFSW VNLDVNFDNV GMAYLALLQV ATFKGWTDIM
     YAAVDFRGDM QQPKFEENQY MYLYFVVFII FGSFFTLNLF IGVIIDNFNQ QQKKLGGQDI
     FMTEEQKKYY NAMKKLGSKK PQKPIPRPLN KCQGLVFDLV TSQVFDILII SLIVLNMISM
     MVESEDQSDD VESTLETLNL AFVAIFTVEC LIKIFALRQY YFTNGWNLFD CVVVVLSIVS
     TMISYLKSKQ NIPFPPTLFR IVRLARIGRI LRLVRAARGI RTLLFALMMS LPSLFNIGLL
     LFLVMFIYAI FGMKYFSEVK QESGIDDMFN FQTFVSSMLC LFQITTSAGW DTLLNPMLKT
     NDPCDFSLEN CYLPAIAIAY FVSYIIISFL IVVNMYIAVI LENFNTATEE SEDPLSEDDF
     EIFYEVWEKF DPEATQFIRY SALSDFADAL PEPLRVAKPN RFQFLVMDLP MVSGDRLHCM
     DVLFAFTTRV LGDSEGLDSV KAMMEEKFME ANPFKKLYEP IVTTTKRKEE ERCAAVIQKA
     FRRYITMTRS ALEDRPHPPL QTLCNGDLSS SGVTEGKVHY D
//
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