ID G3TVR9_LOXAF Unreviewed; 430 AA.
AC G3TVR9;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 66.
DE SubName: Full=Milk fat globule-EGF factor 8 protein {ECO:0000313|Ensembl:ENSLAFP00000019677.1};
GN Name=MFGE8 {ECO:0000313|Ensembl:ENSLAFP00000019677.1};
OS Loxodonta africana (African elephant).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta.
OX NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000019677.1, ECO:0000313|Proteomes:UP000007646};
RN [1] {ECO:0000313|Ensembl:ENSLAFP00000019677.1, ECO:0000313|Proteomes:UP000007646}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000019677.1,
RC ECO:0000313|Proteomes:UP000007646};
RA Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Loxodonta africana (African elephant).";
RL Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLAFP00000019677.1}
RP IDENTIFICATION.
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000019677.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; G3TVR9; -.
DR STRING; 9785.ENSLAFP00000019677; -.
DR Ensembl; ENSLAFT00000026813.1; ENSLAFP00000019677.1; ENSLAFG00000030365.1.
DR eggNOG; ENOG502RXUZ; Eukaryota.
DR GeneTree; ENSGT00940000156049; -.
DR HOGENOM; CLU_030066_0_1_1; -.
DR InParanoid; G3TVR9; -.
DR OMA; YVKTFKV; -.
DR TreeFam; TF330156; -.
DR Proteomes; UP000007646; Unassembled WGS sequence.
DR GO; GO:0009897; C:external side of plasma membrane; IEA:Ensembl.
DR GO; GO:0005615; C:extracellular space; IEA:Ensembl.
DR GO; GO:0005178; F:integrin binding; IEA:Ensembl.
DR GO; GO:0001786; F:phosphatidylserine binding; IEA:Ensembl.
DR GO; GO:0043277; P:apoptotic cell clearance; IEA:Ensembl.
DR CDD; cd00054; EGF_CA; 2.
DR CDD; cd00057; FA58C; 2.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 2.
DR Gene3D; 2.10.25.10; Laminin; 2.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000421; FA58C.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR PANTHER; PTHR46806:SF10; EGF-LIKE REPEAT AND DISCOIDIN I-LIKE DOMAIN-CONTAINING PROTEIN 3 PRECURSOR; 1.
DR PANTHER; PTHR46806; F5/8 TYPE C DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00008; EGF; 2.
DR Pfam; PF00754; F5_F8_type_C; 2.
DR SMART; SM00181; EGF; 2.
DR SMART; SM00231; FA58C; 2.
DR SUPFAM; SSF57196; EGF/Laminin; 2.
DR SUPFAM; SSF49785; Galactose-binding domain-like; 2.
DR PROSITE; PS00022; EGF_1; 2.
DR PROSITE; PS01186; EGF_2; 1.
DR PROSITE; PS50026; EGF_3; 2.
DR PROSITE; PS01285; FA58C_1; 2.
DR PROSITE; PS01286; FA58C_2; 1.
DR PROSITE; PS50022; FA58C_3; 2.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076};
KW Reference proteome {ECO:0000313|Proteomes:UP000007646};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..430
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003455847"
FT DOMAIN 24..62
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 65..109
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 112..268
FT /note="F5/8 type C"
FT /evidence="ECO:0000259|PROSITE:PS50022"
FT DOMAIN 273..430
FT /note="F5/8 type C"
FT /evidence="ECO:0000259|PROSITE:PS50022"
FT DISULFID 33..50
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 52..61
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 99..108
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 430 AA; 47740 MW; CB72B3725E265DB2 CRC64;
MPDLRLLAAL CGALLCATGL FAASGDFCDS SQCLNGGTCL VEMDNAPFYC LCPEGFTGPT
CNETEKGPCL PNPCQHDAKC KVIDDLHRGD IFTPYICKCP QGYAGIHCET RCTMPLGMEG
GAIADSQISA SSVYLGFMGM QRWAPELARL HRTGIVNAWT ASNYDKSPWI QVNLLRKMWV
TGVVTQGASR VGSAEYLRTF KVAYSLDGHK FQFIQDAEGL RDKVFVGNVN NNGQKTNLFD
SPLETQYVRL VPVVCHRACT VRFELLGCEL NGCSEPLGLK DNTIPDKQIT ASSMFKSWGL
NAFSWHPSYA RLDKQGKFNA WTAQSNSASE WLQIDLGLRR RVTGIITQGA RDFGYIQYVA
AYKVAYSDNG QNWTEYKEHG AEDSRIFLGN SDNNSHKKNV FETPFLARFV RVLPVAWHNR
ITLRVELLGC
//
