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Database: UniProt
Entry: G3TWG4_LOXAF
LinkDB: G3TWG4_LOXAF
Original site: G3TWG4_LOXAF 
ID   G3TWG4_LOXAF            Unreviewed;      1917 AA.
AC   G3TWG4;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   30-AUG-2017, entry version 39.
DE   RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
GN   Name=SCN2A {ECO:0000313|Ensembl:ENSLAFP00000019922};
OS   Loxodonta africana (African elephant).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta.
OX   NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000019922, ECO:0000313|Proteomes:UP000007646};
RN   [1] {ECO:0000313|Ensembl:ENSLAFP00000019922}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000019922};
RA   Di Palma F., Heiman D., Young S., Johnson J., Lander E.S.,
RA   Lindblad-Toh K.;
RT   "The Genome Sequence of Loxodonta africana (African elephant).";
RL   Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSLAFP00000019922}
RP   IDENTIFICATION.
RC   STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000019922};
RG   Ensembl;
RL   Submitted (SEP-2011) to UniProtKB.
CC   -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability
CC       of excitable membranes. {ECO:0000256|RuleBase:RU361132}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSLAFP00000019922}.
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DR   Ensembl; ENSLAFT00000030237; ENSLAFP00000019922; ENSLAFG00000001625.
DR   GeneTree; ENSGT00830000128242; -.
DR   Proteomes; UP000007646; Unassembled WGS sequence.
DR   GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:InterPro.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR   InterPro; IPR001696; Na_channel_asu.
DR   InterPro; IPR010526; Na_trans_assoc.
DR   InterPro; IPR024583; Na_trans_cytopl.
DR   Pfam; PF00520; Ion_trans; 4.
DR   Pfam; PF06512; Na_trans_assoc; 1.
DR   Pfam; PF11933; Na_trans_cytopl; 1.
DR   PRINTS; PR00170; NACHANNEL.
DR   SMART; SM00015; IQ; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000007646};
KW   Ion channel {ECO:0000256|RuleBase:RU361132};
KW   Ion transport {ECO:0000256|RuleBase:RU361132};
KW   Membrane {ECO:0000256|RuleBase:RU361132};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007646};
KW   Sodium {ECO:0000256|RuleBase:RU361132};
KW   Sodium channel {ECO:0000256|RuleBase:RU361132};
KW   Sodium transport {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361132};
KW   Transport {ECO:0000256|RuleBase:RU361132};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    125    148       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    193    212       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    224    245       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    251    271       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    388    415       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    712    736       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    748    769       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    831    859       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    921    944       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1146   1164       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1185   1207       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1213   1233       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1262   1288       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1386   1410       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1469   1487       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1499   1517       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1524   1549       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1586   1614       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1690   1713       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   DOMAIN      128    422       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      463    670       Na_trans_cytopl. {ECO:0000259|Pfam:
FT                                PF11933}.
FT   DOMAIN      721    949       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      958   1140       Na_trans_assoc. {ECO:0000259|Pfam:
FT                                PF06512}.
FT   DOMAIN     1144   1418       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1468   1723       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   COILED      412    450       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1917 AA;  218199 MW;  728B3846F71B8ADD CRC64;
     MAQSVLVPPG PDSFRFFTRE SLAAIEQRIA EEKAKRPKQE RKDEDDENGP KPNSDLEAGK
     SLPFIYGDIP PEMVSEPLED LDPYYINKKT FIVLNKGKAI SRFSATPALY ILTPFNPIRK
     LAIKILIHSL FNVLIMCTIL TNCVFMTMSN PPDWTKNVEY TFTGIYTFES LIKILARGFC
     LEDFTFLRDP WNWLDFTVIT FAYVTEFVNL GNVSALRTFR VLRALKTISV IPGLKTIVGA
     LIQSVKKLSD VMILTVFCLS VFALIGLQLF MGNLRNKYIT SFFSSSLDVN GTIINRTVSM
     FNWDEYIEDK SHFYFLEGQN DALLCGNSSD AGQCPEGYIC VKAGRNPNYG YTSFDTFSWA
     FLSLFRLMTQ DFWENLYQLT LRAAGKTYMI FFVLVIFLGS FYLINLILAV VAMAYEEQNQ
     ATLEEAEQKE AEFQQMLEQL KKQQEEAQVE STFTVLKSSS VVSKLRFRKS ESEDSIRRKG
     FRFSLEWLLE AKLPKDRQEN ENQGMNHISL LSIRGSLFSP RRNSRASLFS FRGRAKDIGS
     ENDFADDEHS TFEDNDSRRD SLFVPHRHGE RRHSNVSQAS RASRVLPILP MNGKMHSAVD
     CNGVVSLVGG PSALTSPIGQ LLPEDLLQTG ANSGTTTETE IRKRRSSSYH VSMDLLEDPT
     AKQRAMSMAS ILTNTMEELE ESRQKCPPCW YKFANMCLIW DCCKPWLKVK HLVNLVVMDP
     FVDLAITICI VLNTLFMAME HYPMTEQFSN VLSVGNLVFT GIFTAEMFLK IIAMDPYYYF
     QEGWNIFDGF IVSLSLMELG LANVEGLSVL RSFRLLRVFK LAKSWPTLNM LIKIIGNSVG
     ALGNLTLVLA IIVFIFAVVG MQLFGKSYKE CVCKISSDCE LPRWHMHDFF HSFLIVFRVL
     CGEWIETMWD CMEVAGQTMC LTVFMMVMVI GNLVVLNLFL ALLLSSFSSD NLAATDDDNE
     MNNLQIAVGR MQKGIDYVKR NIREFIQKAF VRKQKALDLN NKKDSCISNH TTVEISSSVE
     KYVVDESDYM SFINNPSLTV TVPIAVGESD FENLNTEEFS SESDMEESKE KLNATSSSEG
     STVDIGAPAE GEQPEAEPEE SLEPEACFTE DCVRKFKCCQ ISIEEGKGKL WWNVRKTCYK
     IVEHNWFETF IVFMILLSSG ALAFEDIYIE QRKTIKTMLE YADKVFTYIF ILEMLLKWVA
     YGFQMYFTNA WCWLDFLIVD VSLVSLTANA LGYSELGAIK SLRTLRALRP LRALSRFEGM
     RVVVNALLGA IPSIMNVLLV CLIFWLIFSI MGVNLFAGKF YHCINYTTGE MFDVSVVNNY
     SECKALIESN QTARWKNVKV NFDNVGLGYL SLLQVATFKG WMDIMYAAVD SRNVELQPKY
     EDNLYMYLYF VIFIIFGSFF TLNLFIGVII DNFNQQKKKF GGQDIFMTEE QKKYYNAMKK
     LGSKKPQKPI PRPANKFQGM VFDFVTKQVF DISIMILICL NMVTMMVETD DQSQEMTNIL
     YWINLVFIVL FTGECVLKLI SLRYYYFTIG WNIFDFVVVI LSIVGMFLAE LIEKYFVSPT
     LFRVIRLARI GRILRLIKGA KGIRTLLFAL MMSLPALFNI GLLLFLVMFI YAIFGMSNFA
     YVKREVGIDD MFNFETFGNS MICLFQITTS AGWDGLLAPI LNSGPPDCDP EKDHPGSSVK
     GDCGNPSVGI FFFVSYIIIS FLVVVNMYIA VILENFSVAT EESAEPLSED DFEMFYEVWE
     KFDPDATQFI EFSKLSDFAA ALDPPLLIAK PNKVQLIAMD LPMVSGDRIH CLDILFAFTK
     RVLGESGEMD ALRIQMEERF MASNPSKVSY EPITTTLKRK QEEVSAIVIQ RAYRRYLLKQ
     KVKKVSCICK KDKGKEGDGT PIKEDTLIDK LHENSTPEKT DVTPSTTSPP SYDSVTK
//
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