ID   G3TYT9_LOXAF            Unreviewed;       609 AA.
AC   G3TYT9;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   27-MAR-2024, entry version 63.
DE   RecName: Full=Metal transporter {ECO:0000256|RuleBase:RU369091};
GN   Name=CNNM1 {ECO:0000313|Ensembl:ENSLAFP00000020747.1};
OS   Loxodonta africana (African elephant).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta.
OX   NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000020747.1, ECO:0000313|Proteomes:UP000007646};
RN   [1] {ECO:0000313|Ensembl:ENSLAFP00000020747.1, ECO:0000313|Proteomes:UP000007646}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000020747.1,
RC   ECO:0000313|Proteomes:UP000007646};
RA   Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., Lindblad-Toh K.;
RT   "The Genome Sequence of Loxodonta africana (African elephant).";
RL   Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSLAFP00000020747.1}
RP   IDENTIFICATION.
RC   STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000020747.1};
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- FUNCTION: Metal transporter. {ECO:0000256|RuleBase:RU369091}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU369091};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU369091}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the ACDP family. {ECO:0000256|ARBA:ARBA00010484,
CC       ECO:0000256|RuleBase:RU369091}.
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DR   AlphaFoldDB; G3TYT9; -.
DR   STRING; 9785.ENSLAFP00000020747; -.
DR   Ensembl; ENSLAFT00000027872.1; ENSLAFP00000020747.1; ENSLAFG00000000165.4.
DR   eggNOG; KOG2118; Eukaryota.
DR   GeneTree; ENSGT00940000157525; -.
DR   HOGENOM; CLU_011310_5_1_1; -.
DR   InParanoid; G3TYT9; -.
DR   OMA; RQNSECC; -.
DR   TreeFam; TF101012; -.
DR   Proteomes; UP000007646; Unassembled WGS sequence.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0010960; P:magnesium ion homeostasis; IEA:InterPro.
DR   CDD; cd04590; CBS_pair_CorC_HlyC_assoc; 1.
DR   Gene3D; 3.10.580.10; CBS-domain; 1.
DR   InterPro; IPR045095; ACDP.
DR   InterPro; IPR000644; CBS_dom.
DR   InterPro; IPR046342; CBS_dom_sf.
DR   InterPro; IPR002550; CNNM.
DR   InterPro; IPR044751; Ion_transp-like_CBS.
DR   PANTHER; PTHR12064; METAL TRANSPORTER CNNM; 1.
DR   PANTHER; PTHR12064:SF28; METAL TRANSPORTER CNNM1; 1.
DR   Pfam; PF00571; CBS; 1.
DR   SUPFAM; SSF54631; CBS-domain pair; 1.
DR   PROSITE; PS51371; CBS; 1.
DR   PROSITE; PS51846; CNNM; 1.
PE   3: Inferred from homology;
KW   CBS domain {ECO:0000256|PROSITE-ProRule:PRU00703};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PROSITE-
KW   ProRule:PRU01193}; Reference proteome {ECO:0000313|Proteomes:UP000007646};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|PROSITE-
KW   ProRule:PRU01193};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, ECO:0000256|PROSITE-
KW   ProRule:PRU01193}.
FT   DOMAIN          1..49
FT                   /note="CNNM transmembrane"
FT                   /evidence="ECO:0000259|PROSITE:PS51846"
FT   DOMAIN          137..203
FT                   /note="CBS"
FT                   /evidence="ECO:0000259|PROSITE:PS51371"
FT   REGION          376..412
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          471..491
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          530..550
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          582..609
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        382..396
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        582..597
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   609 AA;  68630 MW;  47EC30A95066DA29 CRC64;
     MAAAFPVCYP LGRLLDWALR QEISTFYTRE KLLETLRAAD PYNDLVKEEL NIIQGALELR
     TKVVEEVLTP LGDCFMLRSD AVLDFATVSE ILRSGYTRIP VYEGDQRHNI VDILFVKDLA
     FVDPDDCTPL LTVTRFYNRP LHCVFNDTRL DTVLEEFKKG KSHLAIVQRV NNEGEGDPFY
     EVMGIVTLED IIEEIIKSEI LDETDLYTDN RKKQRVPHRE RKRQDFSLFK LSDSEMRVKI
     SPQLLLATHR FMATEVEPFK SLYLSEKILL RLLKHPNVIQ ELKFDEKNKK APEHYLYQRN
     RPVDYFVLLL QGKVEVEVGK EGLRFENGAF TYYGVPAIMT TACSDNDVRK VGSLAGSSVF
     LPVSVSRTFA FSRGDSLAGS PAAVNRSPSR CSGLNRSESP NRERSDFGGS NTQLYSSNNN
     LYTPDYSVHV LSDVQFVKIT RQQYQNALTA CHMDSSPQSP DMEAFAVGDS TKAPTTWGTP
     QTPKDDPAVT PLNDRSSLLC GRSDGLKSPG EVVYLRMEEM AFTQEDVDDF EERGTQQLSL
     SPGAVPTRAA PDSECCNINL DTETSPCSSD FEESVGKKLL RTLSGRKRKR SPDGERTSEE
     NSNLTPLIT
//