ID G3TZJ1_LOXAF Unreviewed; 889 AA.
AC G3TZJ1;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 68.
DE RecName: Full=TIR domain-containing protein {ECO:0000259|PROSITE:PS50104};
OS Loxodonta africana (African elephant).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta.
OX NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000020999.1, ECO:0000313|Proteomes:UP000007646};
RN [1] {ECO:0000313|Ensembl:ENSLAFP00000020999.1, ECO:0000313|Proteomes:UP000007646}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000020999.1,
RC ECO:0000313|Proteomes:UP000007646};
RA Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Loxodonta africana (African elephant).";
RL Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLAFP00000020999.1}
RP IDENTIFICATION.
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000020999.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the Toll-like receptor family.
CC {ECO:0000256|ARBA:ARBA00009634}.
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DR AlphaFoldDB; G3TZJ1; -.
DR STRING; 9785.ENSLAFP00000020999; -.
DR Ensembl; ENSLAFT00000037022.1; ENSLAFP00000020999.1; ENSLAFG00000029454.1.
DR eggNOG; KOG0619; Eukaryota.
DR GeneTree; ENSGT00940000165464; -.
DR HOGENOM; CLU_318753_0_0_1; -.
DR InParanoid; G3TZJ1; -.
DR OMA; NAWVGPW; -.
DR TreeFam; TF351113; -.
DR Proteomes; UP000007646; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR GO; GO:0042832; P:defense response to protozoan; IEA:Ensembl.
DR GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR GO; GO:0002224; P:toll-like receptor signaling pathway; IEA:InterPro.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 4.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR017241; Toll-like_receptor.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR PANTHER; PTHR24365; TOLL-LIKE RECEPTOR; 1.
DR PANTHER; PTHR24365:SF522; TOLL-LIKE RECEPTOR 12; 1.
DR Pfam; PF13855; LRR_8; 2.
DR Pfam; PF01582; TIR; 1.
DR SMART; SM00369; LRR_TYP; 6.
DR SMART; SM00255; TIR; 1.
DR SUPFAM; SSF52058; L domain-like; 2.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR PROSITE; PS50104; TIR; 1.
PE 3: Inferred from homology;
KW Immunity {ECO:0000256|ARBA:ARBA00022859};
KW Inflammatory response {ECO:0000256|ARBA:ARBA00023198};
KW Innate immunity {ECO:0000256|ARBA:ARBA00022588};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000007646};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..26
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 27..889
FT /note="TIR domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003456109"
FT DOMAIN 739..885
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
SQ SEQUENCE 889 AA; 97891 MW; 64A1C2019C138AFE CRC64;
WTRLGAEMGK HLLLLGLLLS LPLITAWTVV NCLVTEGSQL PLVSRYTLLC HLDTSLSLFA
SCSSVTNLTQ VLETVPPSVE GLCLSGSISV LPPDAFSHFP GLKVLGLNLH FTQLLPGALR
GLEQLRRLTF LGRHTDFLYL PPDAFGNLSS LQYLTFSGPC LDGSLGVRLP PGLQLLAVTH
SCLQNVGVLA DIFPDLVLAS SSGDAWALDT LDLSFNKRLN ITSPGALPGL QLRTLHLDHT
NTEVAAVAEL GLQRLDALSA KKTGMAQLPV GVIAHFGLQE LHLGLTQIGR IAPEALASCH
SLKSLDLKSS RLIDLPPGFL AAMPSLQTLK LTINQQQIAM LCMNGTGAES GLWALDLSNN
GLYTMFPDTF SCLPHLRELL LQGNQLFHLD GQVFQGLRRL QTLDLSRNPL AALGKGWLGS
LPALTTLNLL DTQIVLSSAW DFWGPERLNN LRLRLLSGPP RMLSLPVGLA SLELHAVSGM
KPWKLVTDVL PVLQTLTLKG WGLQLGVQNI SKIFPALHQL SLLGNSLEAL CSQDTSHFFL
WQLPGLKQLN VKGDGHNLRP CCITGLPSLR ELKLQLLQSR ARPRPVRLEE LVGELPMLEV
LQLEHTGLET LSAAAFQGLR SLQILVLGWE NGLVLDGSLQ EHSPQMPQYM YFLTSSLACQ
CANAWVGPWL ERSPRTYVHI TTHQLCQPEA GGHSNRPLFP FLWSHCPQTL GLELFLGSSA
LLLLLLQGLR GQRSEGKRFL YDVFLSHCRQ DQGWVVRELL PALEGCPPVG WGLRVCLPER
DFEPGKDVAD NVADSMVGSR ITICVLSQQA LCTPRCLLEL RLATSLLLAA PYLPALLLVF
LEPISRHQLP RYHRLAWLLR RGDYHMWPRE DERKDDFWAW LGRRLGQPG
//
