ID G3U002_LOXAF Unreviewed; 1065 AA.
AC G3U002;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 65.
DE SubName: Full=RNA binding motif protein 27 {ECO:0000313|Ensembl:ENSLAFP00000021160.1};
GN Name=RBM27 {ECO:0000313|Ensembl:ENSLAFP00000021160.1};
OS Loxodonta africana (African elephant).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta.
OX NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000021160.1, ECO:0000313|Proteomes:UP000007646};
RN [1] {ECO:0000313|Ensembl:ENSLAFP00000021160.1, ECO:0000313|Proteomes:UP000007646}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000021160.1,
RC ECO:0000313|Proteomes:UP000007646};
RA Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Loxodonta africana (African elephant).";
RL Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLAFP00000021160.1}
RP IDENTIFICATION.
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000021160.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: May be involved in the turnover of nuclear polyadenylated
CC (pA+) RNA. {ECO:0000256|ARBA:ARBA00043866}.
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DR RefSeq; XP_010589828.1; XM_010591526.1.
DR AlphaFoldDB; G3U002; -.
DR STRING; 9785.ENSLAFP00000021160; -.
DR Ensembl; ENSLAFT00000023062.2; ENSLAFP00000021160.1; ENSLAFG00000022447.2.
DR GeneID; 100660063; -.
DR KEGG; lav:100660063; -.
DR CTD; 54439; -.
DR eggNOG; KOG2135; Eukaryota.
DR GeneTree; ENSGT00510000046929; -.
DR InParanoid; G3U002; -.
DR OMA; CPMEHGL; -.
DR OrthoDB; 5406435at2759; -.
DR TreeFam; TF319253; -.
DR Proteomes; UP000007646; Unassembled WGS sequence.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006397; P:mRNA processing; IEA:InterPro.
DR CDD; cd12517; RRM_RBM27; 1.
DR Gene3D; 3.30.70.330; -; 1.
DR Gene3D; 1.20.1390.10; PWI domain; 1.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR002483; PWI_dom.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR045137; RBM26/27.
DR InterPro; IPR034451; RBM27_RRM.
DR InterPro; IPR000504; RRM_dom.
DR InterPro; IPR000571; Znf_CCCH.
DR PANTHER; PTHR14398; RNA RECOGNITION RRM/RNP DOMAIN; 1.
DR PANTHER; PTHR14398:SF1; RNA-BINDING PROTEIN 27; 1.
DR Pfam; PF01480; PWI; 1.
DR Pfam; PF00076; RRM_1; 1.
DR Pfam; PF00642; zf-CCCH; 1.
DR SMART; SM00360; RRM; 1.
DR SUPFAM; SSF54928; RNA-binding domain, RBD; 1.
DR PROSITE; PS50102; RRM; 1.
DR PROSITE; PS50103; ZF_C3H1; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00723};
KW Reference proteome {ECO:0000313|Proteomes:UP000007646};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|PROSITE-
KW ProRule:PRU00176}; Zinc {ECO:0000256|PROSITE-ProRule:PRU00723};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00723}.
FT DOMAIN 273..301
FT /note="C3H1-type"
FT /evidence="ECO:0000259|PROSITE:PS50103"
FT DOMAIN 606..680
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT ZN_FING 273..301
FT /note="C3H1-type"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00723"
FT REGION 79..144
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 160..278
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 319..422
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 571..598
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 701..732
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 947..974
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1009..1065
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 818..892
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 88..144
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 166..181
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 182..210
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 218..272
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 319..366
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 373..387
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 391..406
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 584..598
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 701..730
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1012..1030
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1031..1057
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1065 AA; 119062 MW; D5EA876D7FF72725 CRC64;
MLIEDVDALK SWLAKLLEPI CDADPSALAN YVVALVKKDK PEKELKAFCA DQLDVFLQKE
TSGFVDKLFE SLYTKNYLPP LEPVKPEPKP SVQEKEEIKE EVFQEPAEEE RDSRKKKYPS
PQKTRSESSE RRTREKKRED GKWRDYDRYY ERNELYREKY DWRRGRSKSR SKSRGLSRSR
SRSRGRSKDR DPNRNVEHRE RSKFKSERND LESSYVPVSA PPPNSSEQYS SGTQSIPSTV
TVIAPAHHSE NTTESWSNYY NNHSSSNSFG RNPPPKRRCR DYDERGFCVL GDLCQFDHGN
DPLVVDEVAL PSMIPFPPPP PGLPPPPPPG ILMPPMPGPG PGPGPGPGPG PGPGPGPGPG
PGPGHSMRLP VPQGHGQPPP SVVLPIPRPP ITQSNLINNR DQPGTSAVPN LAPVGARLPP
PLPQNLLYTV SERQPMYSRE HGAAASERLQ LGTPPPLLAA RLVPPRNLMG SSIGYHTSVS
SPTPLVPDTY EPDGYNPEAP SITSSGRSQY RQFFSRTQTQ RPNLIGLTSG DMDANPRAAN
IVIQTEPPVP VSINSNITRV VLEPDSRKRA MSGLEGPLTK KPWLGKQGNN NQSKPGFLRK
NQYTNTKLEV KKIPQELNNI TKLNEHFSKF GTIVNIQVAF KGDPEAALIQ YLTNEEARKA
ISSTEAVLNN RFIRVLWHRE NNEQPALQSP TQLLLQQQQT LSHLSQQHHH LPQHLHQQQV
LATQSPPSAV HGGIQKMMNK PQTSGAYVLN KVPVKHRLGH ASGNQSDAAH LLNQSGGAGE
DCQIFSAPGH PKMIYSSSNL KTPSKLCSGS KSHDVQEVLK KKQEAMKLQQ DMRKKRQEVL
EKQIECQKML ISKLEKNKNM KPEERANIMK TLKELGEKIS QLKDELKTSS AVSTPSKVKT
KTEAQKELLD TELDLHKRLS SGEDTTELRK KLSQLQVEAA RLGILPVGRG KTMSSQGRGR
GRGRGGRGRG SLNHMVVDHR PKALTVGGFN EEEKDELLQH FSAANQGSKF KDRRLQVWHK
PKVPSISTET EEEEVKEEET ETSDLFLHDD DDEDEDEYES RSWRR
//
