ID G3U2I9_LOXAF Unreviewed; 677 AA.
AC G3U2I9;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE SubName: Full=Amyloid beta precursor protein binding family B member 1 {ECO:0000313|Ensembl:ENSLAFP00000022047.1};
GN Name=APBB1 {ECO:0000313|Ensembl:ENSLAFP00000022047.1};
OS Loxodonta africana (African elephant).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta.
OX NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000022047.1, ECO:0000313|Proteomes:UP000007646};
RN [1] {ECO:0000313|Ensembl:ENSLAFP00000022047.1, ECO:0000313|Proteomes:UP000007646}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000022047.1,
RC ECO:0000313|Proteomes:UP000007646};
RA Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Loxodonta africana (African elephant).";
RL Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLAFP00000022047.1}
RP IDENTIFICATION.
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000022047.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; G3U2I9; -.
DR Ensembl; ENSLAFT00000031432.1; ENSLAFP00000022047.1; ENSLAFG00000027099.1.
DR GeneTree; ENSGT00390000000002; -.
DR Proteomes; UP000007646; Unassembled WGS sequence.
DR GO; GO:0001540; F:amyloid-beta binding; IEA:InterPro.
DR CDD; cd01271; PTB2_Fe65; 1.
DR CDD; cd00201; WW; 1.
DR Gene3D; 2.20.70.10; -; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 2.
DR InterPro; IPR039576; APBB1/2/3.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR006020; PTB/PI_dom.
DR InterPro; IPR001202; WW_dom.
DR InterPro; IPR036020; WW_dom_sf.
DR PANTHER; PTHR14058; AMYLOID BETA A4 PRECURSOR PROTEIN-BINDING FAMILY B; 1.
DR PANTHER; PTHR14058:SF5; AMYLOID BETA PRECURSOR PROTEIN BINDING FAMILY B MEMBER 1; 1.
DR Pfam; PF00640; PID; 2.
DR Pfam; PF00397; WW; 1.
DR SMART; SM00462; PTB; 2.
DR SMART; SM00456; WW; 1.
DR SUPFAM; SSF50729; PH domain-like; 2.
DR SUPFAM; SSF51045; WW domain; 1.
DR PROSITE; PS01179; PID; 2.
DR PROSITE; PS01159; WW_DOMAIN_1; 1.
DR PROSITE; PS50020; WW_DOMAIN_2; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000007646}.
FT DOMAIN 227..259
FT /note="WW"
FT /evidence="ECO:0000259|PROSITE:PS50020"
FT DOMAIN 339..427
FT /note="PID"
FT /evidence="ECO:0000259|PROSITE:PS01179"
FT DOMAIN 509..666
FT /note="PID"
FT /evidence="ECO:0000259|PROSITE:PS01179"
FT REGION 48..67
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 75..110
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 133..178
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 194..230
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 249..273
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 296..321
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 194..223
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 677 AA; 73109 MW; 264C0BEE24E372B4 CRC64;
MSVPSSLSQS AINANSHGGP ALSLPLPLHA AHNQLLNAKL HATAVGPKDL RSMGEGSGPE
PGPANAKWLK EGQNQLRRAA TAHRDQNRNV TLTLAEEPSQ EPETAPLGPK GLMHLYSELE
LSAHNAANRG LRGPGLIIST QEHGPDLSSP PGLPEPLQSV EVPPGPQALA DGPREHSKSA
SLLFGMRNSA ASDEDSSWAT LSQGSPSYGS PEDTDSFWNP NAFETDSDLP AGWMRVQDTS
GTYYWHIPTG TTQWEPPGRA SPSQGSSPRE ESQLTWTGFA HGEGFEDGEF WKGELERGHQ
FGPDSSLPFP PAQSLSPEPL PQEEEKLLPR NANPGIKCFA VRSLGWVEMT EEELAPGRSS
VAVNNCIRQL SYHKNNLHDP MSGGWGEGKD LLLQLEDETL KLVEPQSQAL LHTQPIVSIR
VWGVGRDSGS QSGASFLTLF SASLVLPDPE RSSNRPSLAP SLHTFLPQIM AERRNARCLV
NGLSLDHSKL VDVPFQVEFP APKSELVQKF QVYYLGNVPV AKPVGVDVIN GALESVLSSS
SREQWTPSHV SVAPATLTIL HQQTEAVLGE CRVRFLSFLA VGRDVHTFAF IMAAGPASFC
CHMFWCEPNA ASLSEAVQAA CMLRYQKCLD ARSQASTSCL PAPPAESVAR RVGWTVRRGV
QSLWGSLKPK RLGAHTP
//
