GenomeNet

Database: UniProt
Entry: G3U716_LOXAF
LinkDB: G3U716_LOXAF
Original site: G3U716_LOXAF 
ID   G3U716_LOXAF            Unreviewed;      1934 AA.
AC   G3U716;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   05-JUL-2017, entry version 41.
DE   RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
GN   Name=SCN3A {ECO:0000313|Ensembl:ENSLAFP00000023624};
OS   Loxodonta africana (African elephant).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta.
OX   NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000023624};
RN   [1] {ECO:0000313|Ensembl:ENSLAFP00000023624}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000023624};
RA   Di Palma F., Heiman D., Young S., Johnson J., Lander E.S.,
RA   Lindblad-Toh K.;
RT   "The Genome Sequence of Loxodonta africana (African elephant).";
RL   Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSLAFP00000023624}
RP   IDENTIFICATION.
RC   STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000023624};
RG   Ensembl;
RL   Submitted (SEP-2011) to UniProtKB.
CC   -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability
CC       of excitable membranes. {ECO:0000256|RuleBase:RU361132}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSLAFP00000023624}.
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DR   Ensembl; ENSLAFT00000029315; ENSLAFP00000023624; ENSLAFG00000008951.
DR   eggNOG; KOG2301; Eukaryota.
DR   eggNOG; ENOG410XNP6; LUCA.
DR   GeneTree; ENSGT00830000128242; -.
DR   Proteomes; UP000007646; Unassembled WGS sequence.
DR   GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:InterPro.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR   InterPro; IPR001696; Na_channel_asu.
DR   InterPro; IPR010526; Na_trans_assoc.
DR   InterPro; IPR024583; Na_trans_cytopl.
DR   Pfam; PF00520; Ion_trans; 4.
DR   Pfam; PF06512; Na_trans_assoc; 1.
DR   Pfam; PF11933; Na_trans_cytopl; 2.
DR   PRINTS; PR00170; NACHANNEL.
DR   PROSITE; PS50096; IQ; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000007646};
KW   Ion channel {ECO:0000256|RuleBase:RU361132};
KW   Ion transport {ECO:0000256|RuleBase:RU361132};
KW   Membrane {ECO:0000256|RuleBase:RU361132};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007646};
KW   Sodium {ECO:0000256|RuleBase:RU361132};
KW   Sodium channel {ECO:0000256|RuleBase:RU361132};
KW   Sodium transport {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361132};
KW   Transport {ECO:0000256|RuleBase:RU361132};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    256    276       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    406    433       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    718    736       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    748    771       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    828    856       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    918    941       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1164   1182       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1203   1225       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1231   1251       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1280   1306       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1401   1425       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1484   1502       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1514   1532       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1539   1564       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1601   1629       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1705   1728       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   DOMAIN      134    440       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      513    630       Na_trans_cytopl. {ECO:0000259|Pfam:
FT                                PF11933}.
FT   DOMAIN      630    667       Na_trans_cytopl. {ECO:0000259|Pfam:
FT                                PF11933}.
FT   DOMAIN      718    946       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      955   1157       Na_trans_assoc. {ECO:0000259|Pfam:
FT                                PF06512}.
FT   DOMAIN     1162   1433       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1483   1738       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   COILED      430    471       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1934 AA;  219423 MW;  4BBD5C06D6EEBDA3 CRC64;
     MAQALLVPPG PESFRLFTRE SLAAIEKRAA EEKAKKPKKE QDNDDENKPK PNSDLEAGKN
     LPFIYGDIPP ELVSEPLEDL DPYYIHKKTF IVLNKGKAIF RFSATSALYI LTPLNPVRKI
     AIKILVHSYP FHSTLFSMLI MCTILTNCVF MTLSNPPDWT KNVEYTFTGI YTFESLIKIL
     ARGFCLEDFT FLRDPWNWLD FSVIVMAYVT EFVDLGNVSA LRTFRVLRAL KTISVIPGLK
     TIVGALIQSV KKLSDVMILT VFCLSVFALI GLQLFMGNLR NKCLQWPPSD SAFETNITSH
     FNGTMDSNGT FVNVTMSTFN WKDYIDDDSH FYFLDGQKDP LLCGNGSDAG QCPEGYICVK
     AGRNPNYGYT SFDTFSWAFL SLFRLMTQDY WENLYQLTLR AAGKTYMIFF VLVIFLGSFY
     LVNLILAVVA MAYEEQNQAT LEEAEQKEAE FQQMLEQLKK QQEEAQAVAA ASAASRDFSG
     IGGLGELLES SSEASKLSSK SAKEWRNRRK KRRQREHLEG NNKGERGRFP KSESEDSVKR
     SSFLFSMDGN RLTSDRKFCS PHQSLLSIRG SLFSPRRNSK TSIFSFRGRA KDVGSENDFA
     DDEHSTFEDS ESRRDSLFVP HRHGERRNSN GTTTETEVRK RRLSSYQISM EMLEDSSGRQ
     RAVSIASILT NTMEELEESR QKCPPCWYRF ANVFLIWDCC DAWLKVKHLV NLIVMDPFVD
     LAITICIVLN TLFMAMEHYP MTDQFSSVLT VGNLVFTGIF TAEMVLKIIA MDPYYYFQEG
     WNIFDGIIVS LSLMELGLAN VEGLSVLRSF RLLRVFKLAK SWPTLNMLIK IIGNSVGALG
     NLTLVLAIIV FIFAVVGMQL FGKSYKECVC KISSDCELPR WHMNDFFHSF LIVFRVLCGE
     WIETMWDCME VAGQTMCLIV FMLVMVIGNL VVLNLFLALL LSSFSSDNLA ATDDDNEMNN
     LQIAIGRMQK GIDYVKNKIR KCFQGVFFRK PKVIEIHEGN KIDSCVSNNT GIEISKELNY
     IKDGNGTTSG VGTGSSVEKC VIDENDYMSF INNPSLTVTV PIAVGESDFE NLNTEEFSSE
     SELEESKEKL NATSSSEGST VDVAPPREGE QAEIEPEEDL KPEACFTEGC IKKFPFCQVS
     TEEGKGKVWW NLRKTCYSIV EHNWFETFIV FMILLSSGAL AFEDIYIEQR KTIKTMLEYA
     DKVFTYIFIL EMLLKWVAYG FQTYFTNAWC WLDFLIVDVS LVSLVANALG YSELGAIKSL
     RTLRALRPLR ALSRFEGMRV VVNALVGAIP SIMNVLLVCL IFWLIFSIMG VNLFAGKFYH
     CVNTTTGDMF EVSEVNNLSD CQALGKQARW KNVKVNFDNV GAGYLALLQV ATFKGWMDIM
     YAAVDSRDVK LQPVYEENLY MYLYFVIFII FGSFFTLNLF IGVIIDNFNQ QKKKFGGQDI
     FMTEEQKKYY NAMKKLGSKK PQKPIPRPAN KFQGMVFDFV TRQVFDISIM ILICLNMVTM
     MVETDDQSKY MTLVLSRINL VFIILFTGEF VLKLISLRYY YFTIGWNIFD FVVVILSIVG
     MFLAELIEKY FVSPTLFRVI RLARIGRILR LIKGAKGIRT LLFALMMSLP ALFNIGLLLF
     LVMFIYAIFG MSNFAYVKKE AGIDDMFNFE TFGNSMICLF QITTSAGWDG LLAPILNSAP
     PDCDPDAIHP GSSVKGDCGN PSVGIFFFVS YIIISFLVVV NMYIAVILEN FSVATEESAE
     PLSEDDFEMF YEVWEKFDPD ATQFIEFSKL SDFAAALDPP LLIAKPNKVQ LIAMDLPMVS
     GDRIHCLDIL FAFTKRVLGE SGEMDALRIQ MEDRFMASNP SKVSYEPITT TLKRKQEEVS
     AAIIQRNFRC YLLKQRLKKF SSKYKKEEIK GRINLPIKED MIIDKLNGNS TPEKTDGSSS
     TTSPPSYDSV TKPD
//
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