ID G3U793_LOXAF Unreviewed; 1221 AA.
AC G3U793;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 75.
DE SubName: Full=Rap guanine nucleotide exchange factor 1 {ECO:0000313|Ensembl:ENSLAFP00000023701.1};
GN Name=RAPGEF1 {ECO:0000313|Ensembl:ENSLAFP00000023701.1};
OS Loxodonta africana (African elephant).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta.
OX NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000023701.1, ECO:0000313|Proteomes:UP000007646};
RN [1] {ECO:0000313|Ensembl:ENSLAFP00000023701.1, ECO:0000313|Proteomes:UP000007646}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000023701.1,
RC ECO:0000313|Proteomes:UP000007646};
RA Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Loxodonta africana (African elephant).";
RL Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLAFP00000023701.1}
RP IDENTIFICATION.
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000023701.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; G3U793; -.
DR STRING; 9785.ENSLAFP00000023701; -.
DR Ensembl; ENSLAFT00000032851.1; ENSLAFP00000023701.1; ENSLAFG00000003693.4.
DR eggNOG; KOG3417; Eukaryota.
DR GeneTree; ENSGT00940000156235; -.
DR InParanoid; G3U793; -.
DR OMA; INRQEDF; -.
DR TreeFam; TF317296; -.
DR Proteomes; UP000007646; Unassembled WGS sequence.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; IEA:Ensembl.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0001568; P:blood vessel development; IEA:Ensembl.
DR GO; GO:0060070; P:canonical Wnt signaling pathway; IEA:Ensembl.
DR GO; GO:0098609; P:cell-cell adhesion; IEA:Ensembl.
DR GO; GO:0070371; P:ERK1 and ERK2 cascade; IEA:Ensembl.
DR GO; GO:0090090; P:negative regulation of canonical Wnt signaling pathway; IEA:Ensembl.
DR GO; GO:0070373; P:negative regulation of ERK1 and ERK2 cascade; IEA:Ensembl.
DR GO; GO:2000178; P:negative regulation of neural precursor cell proliferation; IEA:Ensembl.
DR GO; GO:0051898; P:negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction; IEA:Ensembl.
DR GO; GO:0046580; P:negative regulation of Ras protein signal transduction; IEA:Ensembl.
DR GO; GO:0061351; P:neural precursor cell proliferation; IEA:Ensembl.
DR GO; GO:0043491; P:phosphatidylinositol 3-kinase/protein kinase B signal transduction; IEA:Ensembl.
DR GO; GO:0048008; P:platelet-derived growth factor receptor signaling pathway; IEA:Ensembl.
DR GO; GO:0007265; P:Ras protein signal transduction; IEA:Ensembl.
DR CDD; cd00155; RasGEF; 1.
DR CDD; cd06224; REM; 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF99; RAP GUANINE NUCLEOTIDE EXCHANGE FACTOR 1; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00229; RasGEFN; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000007646}.
FT DOMAIN 830..954
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 984..1208
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT REGION 205..233
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 247..297
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 333..374
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 418..479
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 688..808
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 262..289
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 343..374
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 688..760
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1221 AA; 135989 MW; 72FE971EC55B7575 CRC64;
SDSQRSHLSS FTMKLMDKFH SPKIKRTPSK KGKPAEVSVK IPEKPVNKEA TDRFLPEGYP
IPLDLEQQTV EFMSTSAVAS RSQRQKNLSW LEEKEKEVVS ALRYFKTIVD KMAIDKKVLE
MLPGSASKVL EAILPLVQSD PRIQHSSALS SCYSRVYQSL ANLIRWSDQV MLEGVNSEDK
EMVTTVKGVI KAVLDGVKEL VRLTIEKQGH PSPTSPVKPS SPACKPDSQS ELPLTDREME
ILNKTTGMSQ STELLPDSMD EEVAPPKPPL PGIRVVDNSP PPALPPKKRQ SAPSPTRVAV
VAPMSRATSG SSLPVGINRQ DFDVDCYTQR RLSGGSHSYG GESPRLSPCS SIGKLSKSDE
QLSSLDRDSG QCSRNTSCET LDHYDPDYEF LQQDLSNADQ IPQQVACNLS PLPESLGESG
SPFLGHPFQL PLGSCPQPEG PLALGQQTDT PPALPEKKRR SAASQTTDSS GRRVSYERHP
SQYDNISEDD LQMPASVQSI PFTPFAAILP FQQGGSPAPV EFVGDFTVPD STGDPEKPPP
LPEKKNKHML AYMQLLEDYS EPQPSMFYQT PQNEHIYQQK NKHLMEVYGF NDSFSSGDSA
QELAPPPALP PKQRQLQASY AASSFSSVSY CVQQTKVTFT PEDGSATQGI SVSVSNSFLS
RHGNLPVPSY KSVFRSYSQD FVPHSQAPVQ PFLPSTSSSS PHFPPVHQSQ SSDLAVPTIA
SPPSSTVDGP LSSSQESSFH GNTVCLPSET SFTDSPQTPL ESPAVKDGHP KGSSSVGGAP
GKENREGGER APKSPDALEA AQSEEEVDEL SLIDHNEIMA RLTLKQEGDD GPDVRGGSGD
ILLVHATETD RKDLVLYCEA FLTTYRTFIT PEELIKKLQY RYPSQKFSPF ADTFKKRVSK
NTFFVLVRVV DELCLVELTE EILKLLMELV FRLVCNGELS LARVLRKNIL DKVDQKKLLR
CANSDQPLAA RGVAARPGTL HDFHSHEIAE QLTLLDAELF YKIEIPEVLL WAKEQNEEKS
PNLTQFTEHF NNMSYWVRSI IMLQEKAQDR ERLLLKFIKI MKHLRKLNNF NSYLAILSAL
DSAPIRRLEW QKQTSEGLAE YCTLIDSSSS FRAYRAALSE VEPPCIPYLG WKAQQLSFFS
GRAAPHLDFH LPPLRRFRQF NILDSMRAFQ QAHYDIRRND DIVNFFNDFS DHLAEEALWE
LSLKIKPRNI TRRKTDREEK T
//
