ID G3U7M0_LOXAF Unreviewed; 1301 AA.
AC G3U7M0;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 69.
DE SubName: Full=Calcium dependent secretion activator 2 {ECO:0000313|Ensembl:ENSLAFP00000023828.1};
GN Name=CADPS2 {ECO:0000313|Ensembl:ENSLAFP00000023828.1};
OS Loxodonta africana (African elephant).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta.
OX NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000023828.1, ECO:0000313|Proteomes:UP000007646};
RN [1] {ECO:0000313|Ensembl:ENSLAFP00000023828.1, ECO:0000313|Proteomes:UP000007646}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000023828.1,
RC ECO:0000313|Proteomes:UP000007646};
RA Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Loxodonta africana (African elephant).";
RL Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLAFP00000023828.1}
RP IDENTIFICATION.
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000023828.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR STRING; 9785.ENSLAFP00000023828; -.
DR Ensembl; ENSLAFT00000031494.1; ENSLAFP00000023828.1; ENSLAFG00000013553.3.
DR eggNOG; KOG3543; Eukaryota.
DR GeneTree; ENSGT00590000083094; -.
DR InParanoid; G3U7M0; -.
DR OMA; LSFTLEX; -.
DR TreeFam; TF312963; -.
DR Proteomes; UP000007646; Unassembled WGS sequence.
DR GO; GO:0031410; C:cytoplasmic vesicle; IEA:UniProtKB-KW.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0098793; C:presynapse; IEA:GOC.
DR GO; GO:1990504; P:dense core granule exocytosis; IEA:InterPro.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR GO; GO:0016079; P:synaptic vesicle exocytosis; IEA:InterPro.
DR CDD; cd01234; PH_CADPS; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR033227; CAPS.
DR InterPro; IPR010439; MUN_dom.
DR InterPro; IPR014770; Munc13_1.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR12166; CALCIUM-DEPENDENT SECRETION ACTIVATOR; 1.
DR PANTHER; PTHR12166:SF7; CALCIUM-DEPENDENT SECRETION ACTIVATOR 2; 1.
DR Pfam; PF06292; MUN; 1.
DR Pfam; PF00169; PH; 1.
DR SMART; SM01145; DUF1041; 1.
DR SMART; SM00233; PH; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50004; C2; 1.
DR PROSITE; PS51258; MHD1; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 4: Predicted;
KW Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329};
KW Exocytosis {ECO:0000256|ARBA:ARBA00022483};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Reference proteome {ECO:0000313|Proteomes:UP000007646};
KW Transport {ECO:0000256|ARBA:ARBA00022927}.
FT DOMAIN 350..465
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 488..591
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 890..1061
FT /note="MHD1"
FT /evidence="ECO:0000259|PROSITE:PS51258"
FT REGION 1..75
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 398..417
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1279..1301
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..16
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 402..417
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1301 AA; 148040 MW; FA02504B42B9925F CRC64;
MLDPSSSEEE SDEGLEEGSR DVLVAAGGPQ RAPPAPLREG RRDAAGRAGG GGAVRPGSPS
PSVLSEGRDE PERLLDEEQE RRIRLQLYVL VVRCIAYPFN AKQPTDMARR QQKLNKQQLQ
LLKERFQAFL NGETQIVADE AFCNAVRSYY EVFLKSDRVA RMVQSGGCSA NDFREVFKKN
IEKRVRSLPE IDGLSKETVL SSWIAKYDAI YRGEEDVCKQ PTRMALSAVS ELILSKEQLY
EMFQQILGIK KLEHQLLYNA CQLDNADEQA AQIRRELDGR LQLAEKMAKE RKFPKFIAKE
METMYIEELR SSVNLLMANL ESLPVSKGGP EFKLQKLKRS QNSAFLDIGD ENEIQLSKSD
VVLSFTLEIV IMEVQGLKSV APNRIVYCTM EVEGGEKLQT DQAEASRPQW GTQGDFTTTH
PRPVVKVKLF TESTGVLALE DKELGRVVLY PTPNSSKAAE LHRMIVPKNS QDSDLKIKLA
VRMDKPPHMK HSGYLYALGQ KVWKRWKKRY FVLVQVSQYT FAMCSYREKK SEPQELMQLE
GYTVDYTDPH PGLQGGQMFF NAVKEGDAVL FASDDEQDRI LWVQAMYRAT GQSYKPIPAI
QTQKLNPKGG TIHSDAQLYA DRFQKHGMDE FISADPCKLD HAFLFRLLQR QTLDHRLNDS
YSCLGLVSPG QVFVLDEYCA RYGVRGCHRH LCYLTELMEH SENGAVIDPN LLHYSFAFCA
SHVHGNRPDG IGTVSMEEKE KFEEIKERLS SLLENQLSHF RYCFPFGRPE GALKATLSLL
ERVLMKDIAT PVPAEEVKKV VRKCLEKAAL INYTRLTEYA KIEGPAEKET ETMNHASPAR
KLEEVLHLAE LCIEVLQQNE EHHSEVLQAF AWWPDLLAEH AEKFWALFTV DMSTALEAQP
QDSWDSFPLF QLLNNFLRND TLLCNGKFHK HLQEIFVPLV VRYVDLMESS IAQSIHRGFE
QETWQPVKNI ANSLPNVALP KVPSLPLNLP QIPSFSTPTW MASLYESTNG SATSEDLFWK
LDALQMFVFD LHWPEQEFAH HLEQRLKLMA SDMIEACVKR TRTAFELKLQ KASKTTDLRI
PASVCTMFNV LVDAKKQSTK LCALDGGQEQ QYHSKIDDLI DNTVKDVISL LVSKFVSVLE
GVLSKLSRYD EGTFFSSILS FTVKAAAKYV DVPKPGMDLA DTYIMFVRQN QDILRDKVNE
EMYIEKLFDQ WYSSSMKVIC VWLADRLDLQ LHIYQLKTLI KIVKKTYRDF RLQGVLEGTL
NSKTYDTLHR RLTVEEATAS VSEGGGLQGI TMKDSDEEEE G
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