ID G3U7S4_LOXAF Unreviewed; 638 AA.
AC G3U7S4;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 55.
DE SubName: Full=FMR1 autosomal homolog 2 {ECO:0000313|Ensembl:ENSLAFP00000023882.1};
GN Name=FXR2 {ECO:0000313|Ensembl:ENSLAFP00000023882.1};
OS Loxodonta africana (African elephant).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta.
OX NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000023882.1, ECO:0000313|Proteomes:UP000007646};
RN [1] {ECO:0000313|Ensembl:ENSLAFP00000023882.1, ECO:0000313|Proteomes:UP000007646}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000023882.1,
RC ECO:0000313|Proteomes:UP000007646};
RA Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Loxodonta africana (African elephant).";
RL Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLAFP00000023882.1}
RP IDENTIFICATION.
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000023882.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, Cytoplasmic ribonucleoprotein granule
CC {ECO:0000256|ARBA:ARBA00004331}. Postsynapse
CC {ECO:0000256|ARBA:ARBA00034110}. Synapse
CC {ECO:0000256|ARBA:ARBA00034103}.
CC -!- SIMILARITY: Belongs to the FMR1 family.
CC {ECO:0000256|ARBA:ARBA00006633}.
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DR AlphaFoldDB; G3U7S4; -.
DR Ensembl; ENSLAFT00000032177.1; ENSLAFP00000023882.1; ENSLAFG00000001114.3.
DR GeneTree; ENSGT00950000183189; -.
DR Proteomes; UP000007646; Unassembled WGS sequence.
DR GO; GO:0036464; C:cytoplasmic ribonucleoprotein granule; IEA:UniProtKB-SubCell.
DR GO; GO:0098794; C:postsynapse; IEA:UniProtKB-SubCell.
DR GO; GO:0003729; F:mRNA binding; IEA:InterPro.
DR GO; GO:0006417; P:regulation of translation; IEA:InterPro.
DR CDD; cd22505; KH_I_FXR2_rpt1; 1.
DR CDD; cd22508; KH_I_FXR2_rpt2; 1.
DR CDD; cd22511; KH_I_FXR2_rpt3; 1.
DR CDD; cd20476; Tudor_Agenet_FXR2_rpt2; 1.
DR Gene3D; 2.30.30.140; -; 2.
DR Gene3D; 3.30.1370.10; K Homology domain, type 1; 2.
DR InterPro; IPR008395; Agenet-like_dom.
DR InterPro; IPR040148; FMR1.
DR InterPro; IPR022034; FMR1-like_C_core.
DR InterPro; IPR040472; FMRP_KH0.
DR InterPro; IPR032172; FXR1_C1.
DR InterPro; IPR004087; KH_dom.
DR InterPro; IPR004088; KH_dom_type_1.
DR InterPro; IPR036612; KH_dom_type_1_sf.
DR InterPro; IPR047422; KH_I_FXR2_rpt1.
DR InterPro; IPR047424; KH_I_FXR2_rpt2.
DR InterPro; IPR047420; Tudor_Agenet_FXR2_rpt2.
DR InterPro; IPR041560; Tudor_FRM1.
DR PANTHER; PTHR10603; FRAGILE X MENTAL RETARDATION SYNDROME-RELATED PROTEIN; 1.
DR PANTHER; PTHR10603:SF3; FRAGILE X MENTAL RETARDATION SYNDROME-RELATED PROTEIN 2; 1.
DR Pfam; PF05641; Agenet; 1.
DR Pfam; PF12235; FXMRP1_C_core; 1.
DR Pfam; PF16096; FXR_C1; 1.
DR Pfam; PF00013; KH_1; 2.
DR Pfam; PF17904; KH_9; 1.
DR Pfam; PF18336; Tudor_FRX1; 1.
DR SMART; SM00322; KH; 2.
DR SUPFAM; SSF54791; Eukaryotic type KH-domain (KH-domain type I); 2.
DR PROSITE; PS51641; AGENET_LIKE; 2.
DR PROSITE; PS50084; KH_TYPE_1; 2.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Reference proteome {ECO:0000313|Proteomes:UP000007646};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW RNA-binding {ECO:0000256|PROSITE-ProRule:PRU00117}.
FT DOMAIN 1..33
FT /note="Agenet-like"
FT /evidence="ECO:0000259|PROSITE:PS51641"
FT DOMAIN 46..98
FT /note="Agenet-like"
FT /evidence="ECO:0000259|PROSITE:PS51641"
FT REGION 362..638
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 380..417
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 418..451
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 465..488
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 588..602
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 638 AA; 70724 MW; 8D8392EDF559DC2D CRC64;
GFVKDVHEDS VTIFFENNWQ SERQIPFGDV RLPPPADYNK EITEGDEVEV YSRANEQEPC
GWWLARVRMM KGDFYVIEYA ACDATYNEIV TLERLRPVNP NPLATKGSFF KVTMAVPEDL
REACSNENVH KEFKKALGAN CIFLNITNSE LFILSTTEAP VKRASLLGDM HFRSLRTKLL
LMSRNEEATK HLETSKQLAA AFQEEFTVRE DLMGLAIGTH GANIQQARKV PGVTAIELGE
ETCTFRIYGE TPEACRQARS YLEFSEDSVQ VPRNMVGKVI GKNGKVIQEI VDKSGVVRVR
VEGDNDKKNP REEGMVPFIF VGTRENISNA QALLEYHLSY LQEVEQLRLE RLQIDEQLRQ
IGLGFRPPGS GRGSGGSDKA GYTTDESSSS SLHTTRTYGG SWTGGSAYGP GSDPSTASET
ESEKREEPNR AGPGDRDPPT RGEESRRRPT GGRGRGPPPA PRPTSRYNSS SISSVLKDPD
SNPYSLLDTS EPEPPADSEP GEPPPASARR RRSRRRRTDE DRTVMDGGLE SDGPNMTENG
LEDESRPQRR NRSRRRRNRG NRTDGSISGD RQPVTVADYI SRAESQSRQR PALERTKPSE
DSLSGQKGDS VSKLPKGPSE NGELSTPLEL GSLVNGVS
//
