GenomeNet

Database: UniProt
Entry: G3U980_LOXAF
LinkDB: G3U980_LOXAF
Original site: G3U980_LOXAF 
ID   G3U980_LOXAF            Unreviewed;       374 AA.
AC   G3U980;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   08-NOV-2023, entry version 58.
DE   RecName: Full=Peptidase A1 domain-containing protein {ECO:0000259|PROSITE:PS51767};
OS   Loxodonta africana (African elephant).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta.
OX   NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000024388.1, ECO:0000313|Proteomes:UP000007646};
RN   [1] {ECO:0000313|Ensembl:ENSLAFP00000024388.1, ECO:0000313|Proteomes:UP000007646}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000024388.1,
RC   ECO:0000313|Proteomes:UP000007646};
RA   Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., Lindblad-Toh K.;
RT   "The Genome Sequence of Loxodonta africana (African elephant).";
RL   Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSLAFP00000024388.1}
RP   IDENTIFICATION.
RC   STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000024388.1};
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the peptidase A1 family.
CC       {ECO:0000256|ARBA:ARBA00007447, ECO:0000256|RuleBase:RU000454}.
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DR   AlphaFoldDB; G3U980; -.
DR   STRING; 9785.ENSLAFP00000024388; -.
DR   MEROPS; A01.006; -.
DR   Ensembl; ENSLAFT00000034170.1; ENSLAFP00000024388.1; ENSLAFG00000031820.1.
DR   eggNOG; KOG1339; Eukaryota.
DR   GeneTree; ENSGT00940000162710; -.
DR   HOGENOM; CLU_013253_3_0_1; -.
DR   InParanoid; G3U980; -.
DR   OMA; QNHHRFN; -.
DR   TreeFam; TF314990; -.
DR   Proteomes; UP000007646; Unassembled WGS sequence.
DR   GO; GO:0004190; F:aspartic-type endopeptidase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   Gene3D; 6.10.140.60; -; 1.
DR   Gene3D; 2.40.70.10; Acid Proteases; 2.
DR   InterPro; IPR001461; Aspartic_peptidase_A1.
DR   InterPro; IPR001969; Aspartic_peptidase_AS.
DR   InterPro; IPR012848; Aspartic_peptidase_N.
DR   InterPro; IPR033121; PEPTIDASE_A1.
DR   InterPro; IPR021109; Peptidase_aspartic_dom_sf.
DR   PANTHER; PTHR47966; BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED; 1.
DR   PANTHER; PTHR47966:SF13; CHYMOSIN; 1.
DR   Pfam; PF07966; A1_Propeptide; 1.
DR   Pfam; PF00026; Asp; 1.
DR   PRINTS; PR00792; PEPSIN.
DR   SUPFAM; SSF50630; Acid proteases; 1.
DR   PROSITE; PS00141; ASP_PROTEASE; 2.
DR   PROSITE; PS51767; PEPTIDASE_A1; 1.
PE   3: Inferred from homology;
KW   Aspartyl protease {ECO:0000256|RuleBase:RU000454};
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157,
KW   ECO:0000256|PIRSR:PIRSR601461-2};
KW   Hydrolase {ECO:0000256|RuleBase:RU000454};
KW   Protease {ECO:0000256|RuleBase:RU000454};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007646}.
FT   DOMAIN          67..371
FT                   /note="Peptidase A1"
FT                   /evidence="ECO:0000259|PROSITE:PS51767"
FT   ACT_SITE        85
FT                   /evidence="ECO:0000256|PIRSR:PIRSR601461-1"
FT   ACT_SITE        267
FT                   /evidence="ECO:0000256|PIRSR:PIRSR601461-1"
FT   DISULFID        98..103
FT                   /evidence="ECO:0000256|PIRSR:PIRSR601461-2"
FT   DISULFID        258..262
FT                   /evidence="ECO:0000256|PIRSR:PIRSR601461-2"
FT   DISULFID        301..334
FT                   /evidence="ECO:0000256|PIRSR:PIRSR601461-2"
SQ   SEQUENCE   374 AA;  41558 MW;  E9CAC0E0A6EF74C5 CRC64;
     RCPTLTLILP HLLRVHLHKG KSMRQALKES GLLDDFLRKH QYAIGRKYSN SGMVAREPLI
     NYLDSQYFGK IYIGTPSQEF TVVFDTGSSD FWVPSVYCNS DACQNHHCFN LFKSSTFQNM
     GQPLTIQYGT GSMQGFLGYD TVTVSDIVDP QQTVGLSTQE PGNVFTYAEF DGILGLAYPS
     LASEYLVPVF DNMMYRHLVP HDLFSVYMSR NDQGSVLTLG AIDSSYYTGS LHWVPVTLQE
     YWQFTVDSIT VDGVLVACDG GCQAILDTGT SLLAGPNNDI LNIQKVIGAT RGQYGQFNID
     CGRLSSMPVV VFEIQGRRYP LPPSAYTNQD QGSCTSGFQS NSDPQQWILG DVFIREYYSV
     FDRANNCVGL AKAI
//
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