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Database: UniProt
Entry: G3U9F3_LOXAF
LinkDB: G3U9F3_LOXAF
Original site: G3U9F3_LOXAF 
ID   G3U9F3_LOXAF            Unreviewed;      4936 AA.
AC   G3U9F3;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   22-NOV-2017, entry version 42.
DE   SubName: Full=Ryanodine receptor 1 {ECO:0000313|Ensembl:ENSLAFP00000024461};
GN   Name=RYR1 {ECO:0000313|Ensembl:ENSLAFP00000024461};
OS   Loxodonta africana (African elephant).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta.
OX   NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000024461};
RN   [1] {ECO:0000313|Ensembl:ENSLAFP00000024461}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000024461};
RA   Di Palma F., Heiman D., Young S., Johnson J., Lander E.S.,
RA   Lindblad-Toh K.;
RT   "The Genome Sequence of Loxodonta africana (African elephant).";
RL   Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSLAFP00000024461}
RP   IDENTIFICATION.
RC   STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000024461};
RG   Ensembl;
RL   Submitted (SEP-2011) to UniProtKB.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSLAFP00000024461}.
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DR   Ensembl; ENSLAFT00000026528; ENSLAFP00000024461; ENSLAFG00000032372.
DR   GeneTree; ENSGT00760000119152; -.
DR   Proteomes; UP000007646; Unassembled WGS sequence.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR   CDD; cd12877; SPRY1_RyR; 1.
DR   CDD; cd12878; SPRY2_RyR; 1.
DR   CDD; cd12879; SPRY3_RyR; 1.
DR   Gene3D; 1.25.10.30; -; 2.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR035910; IP3R_RIH_dom_sf.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR033215; RyR1.
DR   InterPro; IPR035761; SPRY1_RyR.
DR   InterPro; IPR035764; SPRY2_RyR.
DR   InterPro; IPR035762; SPRY3_RyR.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 4.
DR   PANTHER; PTHR13715:SF15; PTHR13715:SF15; 4.
DR   Pfam; PF13833; EF-hand_8; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 2.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF100909; SSF100909; 1.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF49899; SSF49899; 2.
DR   SUPFAM; SSF82109; SSF82109; 1.
DR   PROSITE; PS50188; B302_SPRY; 3.
DR   PROSITE; PS50919; MIR; 4.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000007646};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007646};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4469   4489       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4547   4570       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4736   4758       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4817   4840       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      105    165       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      172    217       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      223    277       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      345    402       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      591    807       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1033   1225       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1346   1566       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
SQ   SEQUENCE   4936 AA;  555385 MW;  964617AE9E18CC07 CRC64;
     MGDGGEGEDD VQFLRTDDEV VLQCNATVLK EQLKLCLAAE GFGNRLCFLE PTSNAQNVPP
     DLAICCFVLE QSLSVRALQE MLANTVEAGV EACEWYFMSS QGGGHRTLLY GHAILLRHAH
     SRMYLSCLTT SRSMTDKLAF DVGLQEDALS PPLIGEACWW TTHPASKQRS EGEKVRVGDD
     LILVSVSSER YLHLSTASGE LQVDASFMQT LWNMNPISSC CEEGYVTGGH VLRLFHGHMD
     ECLTISPADS DDQRRLVYYE GGSVCTHARS LWRLEPLRIS FKGRDWRGFE GKHRKPQREI
     KALSDPGVSS VDATKAHTKA TSLCFRFSKE KLDVGPKRDV EGMGPPEIKY GESLCFVQHV
     ASGLWLTYAA PDPKALRLGV LKKKAMLHQE GHMDDALSLT RCQQEESQAA RMIHSTAGLY
     NHFIKGLDSF SGKPRGAGPP AGTALPIEGV ILSLQDLIGY FEPPLEELRH EEKQSKLRSL
     RNRQSLSPQE GMLSLVLNCI DRLNVYTTAA HFAEFAGEEA AESWKEIVNL LYELLASLIR
     GNRANCALFC TNLDWLVSKL DRLEASSGIL EVLYCVLIES PEVLNIIQEN HIKSIISLLD
     KHGRNHKVLD VLCSLCVCNG VAVRSNQDLI TENLLPGREL LLQTNLINYV TSIRPNIFVG
     RAEGSTQYGK WYFEVMVDEV VPFLTAYPTH LRVGWALTEG YSPYPGGGEG WGGNGVGDDL
     YSYGFDGLHL WTGHVARPVT SPGQHLLAPD DVVSCCLDLS VPSISFRING CPVQGVFEAF
     NLDGLFFPVV SFSAGVKVRF LLGGRHGEFK FLPPPGYAPC HEAVLPRERL RLEPIKEYRR
     EGPRGPHLVG PSRCLSHTDF VPCPVDTVQI VLPPHLERIR EKLAENIHEL WALTRIEQGW
     TYGPVRDDNK RLHPCLVDFH SLPEPERNYN LQMSGETLKT LLALGCHVGM ADEKAEDNLK
     KTKLPKTIQK VRTPKPGVWG SRVLRSERDQ RSEIPTLRAK DHGTLGSRTR KQWFHGSVMK
     LVKANHPPTL APDHDPDQFT APISPFTSLG VSVLRELTAK GKYLGAQSPP ASLTLPGPIC
     RQSRWDRVRI FRAERSYAVQ SGRWYFEFEA VTTGEMRVGW ARPELRPDVE LGADELAYVF
     NGHRGQRWHL GSEPFGRPWQ PGDVVGCMID LTENNIIFTL NGEVLMSDSG SETAFRDIEI
     GDGFLPVCSL GPGQVGHLNL GQDVSSLRFF AICGLQEGFE PFAINMQRPV TTWFSKSLPQ
     FEAVPSEHPH YEVSRVDGTV DTPPCLRLTH RTWGSQNSLV EMLFLRLSLP VQFYQHFRCT
     AGATPLAPPG QQPPAEDEAR AAEPDPDYEN LCRSAGRRAQ PTRVENEKDA TTEKNKKRGI
     THEDPQKAKK AAMMTQPPAT PTLPRLPHDV VPTDDRDDPE IILNTTTYYY SVRVFAGQEP
     SCVWVGWVTP DYHQHDMNFD LSKVRAVTVT MGDEHGNVHS SLKCSNCYMV WGGDFVSPGQ
     QGRISHTDLI IGCLVDLATG LMTFTANGKE SNTFFQVEPN TKLFPALFVL PTHQNVVQFE
     LGKLKNIMPL SAAMFLSERK NSAPQCPRLE VQMLMPISWS RMPNHFLQVE TRRAGERLGW
     AVQCQEPLTM MALHIPEENR CMDILELSER LDLQRFHSHT LRLYRAVCAL GNNRVAHALC
     SHVDQAQLLH ALEDAHLPGP LRAGYYDLLI SIHLESACRS RRTMLSEYIV PLTPETRAIT
     LFPPGRGEDG GSRHHGLPGV GVSTSLRPPH HFLPPCFVAA LPAAGAAEAP ARLSPAIPLE
     ALRDKALRML GEAVQDGRQH ARDPVGGSVE FQFVPVLKLV STLLVMGVFG DEDVKQILKM
     IDPEVFTAEG DKEEGLEEGL LQMKLPESVK LQMCHLLEYF CDQELQHRVE SLAAFAERYV
     DKLQANQRGR YGLLMTAFNM TAAETARRTR EFRSPPQEQI NMLLHFKDGV DEEDCSLPEE
     IRQYLLDFHQ DLLAHCGIQL EGEEEEPEEE ATLGSRLMSL LEKVRLVKKK EKPEEEPAAE
     KHRKESLQEL VSHTVVRWAR EDFVQSPELV RAMFSLLHRQ YDGLGELLRA MPRAYTISPS
     SVDDTMSLLE CLGQIRSLLI VQMGPQEENL MIQSIGNIMN NRVFYQHPNL MRALGMHETV
     MEVMVNVLGG GGGESKEIRF PKMVTSCCRF LCYFCRISRQ NQRSMFDHLS YLLENSGIGL
     ALAPTGMQGS TPLDVAAASV IDNNELALAL QEQDLEKVVS YLAGCGLQSC PMLLAKGYPD
     IGWNPCGGER YLDFLRFAVF VNGESVEENA NVVVRLLIRK PECFGPALRG EGGSGLLAAI
     EEAIRISEDP ARDGPGVRRE RRREHFGEEP PEENRVHLGH AIMSFYAALI DLLGRCAPEM
     HLIQAGKGEA LRIRAILRSL VPLDDLVGII SLPLQIPTLG KDGALVQPKM SASFVPDHKA
     SMVLFLDRVY GIDSQDFLLH VLDVGFLPDM RAAASLDTAT FSTTEMALAL NRYLCLAVLP
     LITKCAPLFA GTEHRAIMVD SMLHTVYRLS RGRSLTKAQR DIIEDCLMAL CRYIRPSMLQ
     HLLRRLVFDV PILNEFAKMP LKLLTNHYER CWKYYCLPTG WANFGVTSEE ELHLTRKLFW
     GIFDSLAHKK YDPDLYRMAM PCLCAIAGAL PPDYVDASYS SKAEKKATVD AEGNFDPRPV
     ETLNVDHPRR GLTPLLQVRR RYTHEKWGFD RLGIRGLMLG FTPSAHSINY PSSCPPQDKE
     IYRWPLTESQ KDMIAWEWTI EKARGGEKKK TRKISQSAQV ETYDPREGYN PQPPDLSGVT
     LSRELQAMAE QLAENYHNTW GRKKKQELEA KGGGSHPLLV PYDTLTAKEK ARDREKAQEL
     LKFLQMNGYA VTRGWEETFL IVPGKLKKKR HSTCSIIRGQ YDYFNSIIVI IIMCEVDFRF
     KAGSFRYYSS ERKACDEILL PLINQYFTNH CLYFLSTPAK VLGSGGHASN KEKEMITSLF
     CKLAALVRHR VSLFGTDAPA VVNCLHILAR SLDARTVMKS GPEIVKAGLR SFFESASEDI
     EKMVENLRLG KVSQARTQVK GVGQNLTYTT VALLPVLTTL FQHIAQHQFG DDVILDDVQV
     SCYRTLCSIY SLGTTKSTYV EKAAPALGEC CDNKLELLPT AASFSHKFSC SPYNVTAHSS
     FPPRISYSNQ PAPVPCCLLI SPPDRSCPFS LLYLLELRST PFTRIILCLT VQPNLCLKSW
     LWEWFQNLRC APHFSPAPSG TLCCVPCQGG HCRNLQFYRR LGWGESCPRR EGLLWQPMLP
     VPSSTSPTFL IFTLGQAAQQ RLLCSENRPW LSFPKCWACS MCPFVIMQNL SLWPPSLGTL
     PQALTDPPPL PRAHWLTAPN ANAEELFRMV GEIFIYWSKS HNFKREEQNF VVQNEINNMS
     WNMKPALSPM SPQSGGSDQE RTKKQRRGDR YSVQTSLIVA TLKKMLPIGL NMCAPTDQEL
     IMLAKTRYAL KDTDEEVREY LQNNLHLQGK VEGSPSLRWQ MALYRGLPGR EEDADDPEKI
     VRRVQEVSAV LYHLEQRKTG EIVRYRLMEH PYKSKKAVWH KLLSKQRRRA VVACFRMTPL
     YNLPTHRACN MFLESYKAAW ILTEDHSFED RMIDDLSRKP GSSVSRFPPS GTMIHLYCCR
     GGTRRSKLDE DYLYMAYADI MAKSCHLEEA EENVNMNAEE EVEVSFEEKE MEKQRLLYQQ
     ARLHSRGAAE MVLQMISACK GAERQAPWCP STLKLGISIN GGNADVQQKM LDYLKDKKEV
     GFFQSIQVLM QTCSVLDLNA FERQNKAEGL GMVNEDGTGE KVMADDEFTQ DLFRFLQLLC
     EGHNNDFQNY LRTQTGNTTT INIIICTVDY LLRLQESISD FYWYYSGKDV IEEQGKRNFS
     KAMSVAKQVF NSLTEYIQGP CTGNQQSLAH SRLWDAVVGF LHVFAHMMMK LAQDSSQIEL
     LKELLDLQKD MVVMLLSLLE GNVVNGMIAR QMVDMLVESS SNVEMILKFF DMFLKLKDIV
     GSEAFQDYVT DPRGLISKKD FQKAMDSQKQ FTGPEIQFLL SCSEADENEM INCDEFANRF
     EEPARDIGFN VAVLLTNLSE HVPHDPRLRN FLELAESILE YFRPYLGRIE IMGASRRIER
     IYFEISETNR AQWEMPQVSR PAHVHACSAG LPCAWLVLAY SFCTLPLWAL ELSSSGTLVS
     LGASLYTHPA SGPHVTAPSL HPECLHTPAS AIQHGSVTLT SLLFLQTPTS PCSLLLVPAS
     QCLSSIHGCP YTPRPSCSQI IAIIASAMWN VPAAVLTSNS APKNAYRLLV TLLAATMRGS
     ISKRAGGLGD MGDTTPAEPP TPEGSPILKR KLGVRVRVGL SGSPEKGLND QVVLLGEGNE
     QKGRQRGTVD GQEEELPPEP EPEPEPEKAD AENGEKEEVP EPPPEPPKKT APPTPPPKKE
     EAKGGGMEFW GELEVQRVKF LNYLSRNFYT LRFLALFLAF AINFILLFYK VLVMRKGPSY
     PGRGNTRALG VMPMTEITGQ KHSVVVVYYF LEESTGYMEP ALRCLSLLHT LVAFLCIIGY
     NCLKVPLVIF KREKELARKL EFDGLYITEQ PEDDDVKGQW DRLVLNTPSF PSNYWDKFVK
     RKVLDKHGDI YGRERIAELL GMDLATLEIT AHNERKPKPP PGLLTWLMSI DVKYQIWKFG
     VIFTDNSFLY LGWYMVMSLL GHYNNFFFAA HLLDIAMGVK TLRTILSSVT HNGKQLVMTV
     GLLAVVVYLY TVVAFNFFRK FYNKSEDEDE PDMKCDDMMT CYLFHMYVGV RAGGGIGDEI
     EDPAGDEYEL YRVVFDITFF FFVIVILLAI IQGLIIDAFG ELRDQQEQVK EDMETKCFIC
     GIGSDYFDTT PHGFETHTLE EHNLANYMFF LMYLINKDET EHTGQESYVW KMYQERCWDF
     FPAGDCFRKQ YEDQLS
//
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