ID G3UA41_LOXAF Unreviewed; 789 AA.
AC G3UA41;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 67.
DE SubName: Full=Transient receptor potential cation channel subfamily V member 3 {ECO:0000313|Ensembl:ENSLAFP00000024699.1};
GN Name=TRPV3 {ECO:0000313|Ensembl:ENSLAFP00000024699.1};
OS Loxodonta africana (African elephant).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta.
OX NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000024699.1, ECO:0000313|Proteomes:UP000007646};
RN [1] {ECO:0000313|Ensembl:ENSLAFP00000024699.1, ECO:0000313|Proteomes:UP000007646}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000024699.1,
RC ECO:0000313|Proteomes:UP000007646};
RA Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Loxodonta africana (African elephant).";
RL Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLAFP00000024699.1}
RP IDENTIFICATION.
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000024699.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR AlphaFoldDB; G3UA41; -.
DR Ensembl; ENSLAFT00000036062.1; ENSLAFP00000024699.1; ENSLAFG00000013204.3.
DR GeneTree; ENSGT00940000158281; -.
DR HOGENOM; CLU_012795_0_0_1; -.
DR Proteomes; UP000007646; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005216; F:monoatomic ion channel activity; IEA:InterPro.
DR CDD; cd22194; TRPV3; 1.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR024862; TRPV.
DR InterPro; IPR008347; TrpV1-4.
DR PANTHER; PTHR10582:SF6; TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL SUBFAMILY V MEMBER 3; 1.
DR PANTHER; PTHR10582; TRANSIENT RECEPTOR POTENTIAL ION CHANNEL PROTEIN; 1.
DR Pfam; PF00023; Ank; 1.
DR Pfam; PF12796; Ank_2; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR PRINTS; PR01768; TRPVRECEPTOR.
DR SMART; SM00248; ANK; 4.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 2.
DR PROSITE; PS50088; ANK_REPEAT; 2.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000007646};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 437..459
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 479..506
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 518..539
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 545..564
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 585..607
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 650..674
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REPEAT 212..244
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 338..361
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 439..686
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT REGION 1..23
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 51..114
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 53..108
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 789 AA; 90319 MW; E30126D26BCEFEED CRC64;
MNAHPKEMVP LMGRKAMAPS GNPAVLQEKR PAELTPTKKS AHFFLEIEGF EPNPTISKTS
PPIFSKPMDS NIRQCISGNC EDMDSPQSPQ DDVTETPSNP NSPSANLAKG EQRRKKKRLK
KRIFAAVSEG CVDELVELLV ELRELCRRRS DLDVPGQLLM HKLTSDTGKT SLMKALLNIN
PTKEIVRTLL FAEENDILDR FINAEYTEEA YEGQTALNIA IERRQGDIAA VLIAAGADVN
AHAKGVFFNP KYQHEGFYFG ETPLALAACT NQPEIVELLM ENEQTDIASQ DSRGNNILHA
LVTVAEDFKT QNDFVKRMYD MILLRSRNWE LETTRNNEGL TPLQLAAKMG KAEVLNYILS
REIKEKPLRS LSRKFTDWAY GPVSSSLYDL TNVDTMTDNS VLEIIVYNTN IDNRPEMLTL
EPLHTLLHMK WKKFAKYMFF LSFCFYFFYN ITLTLVSYYR PREEEALPHP LALTHKMGWL
QLLGRMFVLI WAMCISVKEG IAIFFLRPSD LQSILSDAWF HFVFFIQAVL VILSVFLYLF
AYKEYLACLV LAMALGWANM LYYTRGFQSM GMYSVMIQKV ILHDVLKFLF VYILFLLGFG
VALASLIEKC SKDNSNCSSY GSFGDAVLEL FKLTIGLGDL NIQQNSKYPI LFLFLLITYV
ILTFVLLLNM LIALMGETVE NVSKESERIW RLQRARTILE FEKMLPEWLR SRFRMGELCK
VAENDFRLCL RINEVKWTEW KTHVSFLNED PGPVKRTADL NKIQNLSRSN SKTTLNAFDE
IDEFPETSV
//
