GenomeNet

Database: UniProt
Entry: G3UG01_LOXAF
LinkDB: G3UG01_LOXAF
Original site: G3UG01_LOXAF 
ID   G3UG01_LOXAF            Unreviewed;      4982 AA.
AC   G3UG01;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   30-AUG-2017, entry version 42.
DE   SubName: Full=Ryanodine receptor 1 {ECO:0000313|Ensembl:ENSLAFP00000026759};
GN   Name=RYR1 {ECO:0000313|Ensembl:ENSLAFP00000026759};
OS   Loxodonta africana (African elephant).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta.
OX   NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000026759};
RN   [1] {ECO:0000313|Ensembl:ENSLAFP00000026759}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000026759};
RA   Di Palma F., Heiman D., Young S., Johnson J., Lander E.S.,
RA   Lindblad-Toh K.;
RT   "The Genome Sequence of Loxodonta africana (African elephant).";
RL   Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSLAFP00000026759}
RP   IDENTIFICATION.
RC   STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000026759};
RG   Ensembl;
RL   Submitted (SEP-2011) to UniProtKB.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSLAFP00000026759}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   STRING; 9785.ENSLAFP00000026759; -.
DR   Ensembl; ENSLAFT00000037324; ENSLAFP00000026759; ENSLAFG00000032372.
DR   eggNOG; KOG2243; Eukaryota.
DR   eggNOG; ENOG410YCNW; LUCA.
DR   GeneTree; ENSGT00760000119152; -.
DR   InParanoid; G3UG01; -.
DR   OMA; DIPARRN; -.
DR   OrthoDB; EOG091G00T0; -.
DR   TreeFam; TF315244; -.
DR   Proteomes; UP000007646; Unassembled WGS sequence.
DR   GO; GO:0005938; C:cell cortex; IEA:Ensembl.
DR   GO; GO:0070062; C:extracellular exosome; IEA:Ensembl.
DR   GO; GO:0031674; C:I band; IEA:Ensembl.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0030314; C:junctional membrane complex; IEA:Ensembl.
DR   GO; GO:0033017; C:sarcoplasmic reticulum membrane; IEA:Ensembl.
DR   GO; GO:0005790; C:smooth endoplasmic reticulum; IEA:Ensembl.
DR   GO; GO:0030315; C:T-tubule; IEA:Ensembl.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0048763; F:calcium-induced calcium release activity; IEA:Ensembl.
DR   GO; GO:0002020; F:protease binding; IEA:Ensembl.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:Ensembl.
DR   GO; GO:0005245; F:voltage-gated calcium channel activity; IEA:Ensembl.
DR   GO; GO:0071313; P:cellular response to caffeine; IEA:Ensembl.
DR   GO; GO:0006936; P:muscle contraction; IEA:Ensembl.
DR   GO; GO:0043931; P:ossification involved in bone maturation; IEA:Ensembl.
DR   GO; GO:0003151; P:outflow tract morphogenesis; IEA:Ensembl.
DR   GO; GO:0014808; P:release of sequestered calcium ion into cytosol by sarcoplasmic reticulum; IEA:Ensembl.
DR   GO; GO:0001666; P:response to hypoxia; IEA:Ensembl.
DR   GO; GO:0048741; P:skeletal muscle fiber development; IEA:Ensembl.
DR   GO; GO:0043588; P:skin development; IEA:Ensembl.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR033215; RyR1.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   PANTHER; PTHR13715:SF97; PTHR13715:SF97; 1.
DR   Pfam; PF13833; EF-hand_8; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 2.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF100909; SSF100909; 1.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF49899; SSF49899; 2.
DR   SUPFAM; SSF82109; SSF82109; 1.
DR   PROSITE; PS50188; B302_SPRY; 3.
DR   PROSITE; PS50919; MIR; 4.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000007646};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007646};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4505   4525       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4782   4804       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4863   4886       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       98    153       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      160    205       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      211    265       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      333    390       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      579    795       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1002   1208       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1356   1570       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
SQ   SEQUENCE   4982 AA;  558482 MW;  965544375EB662D2 CRC64;
     MGDGGEGEDD VQFLRTDDEV VLQCNATVLK EQLKLCLAAE GFGNRLCFLE PTSNAQNVPP
     DLAICCFVLE QSLSVRALQE MLANTVEAGV ESSQGGGHRT LLYGHAILLR HAHSRMYLSC
     LTTSRSMTDK LAFDVGLQED AIGEACWWTT HPASKQRSEG EKVRVGDDLI LVSVSSERYL
     HLSTASGELQ VDASFMQTLW NMNPISSCCE EGYVTGGHVL RLFHGHMDEC LTISPADSDD
     QRRLVYYEGG SVCTHARSLW RLEPLRISFK GRDWRGFEGK HRKPQREIKA LSDPGVSSVD
     ATKAHTKATS LCFRFSKEKL DVGPKRDVEG MGPPEIKYGE SLCFVQHVAS GLWLTYAAPD
     PKALRLGVLK KKAMLHQEGH MDDALSLTRC QQEESQAARM IHSTAGLYNH FIKGLDSFSG
     KPRGAGPPAG TALPIEGVIL SLQDLIGYFE PPLEELRHEE KQSKLRSLRN RQSLSPQEGM
     LSLVLNCIDR LNVYTTAAHF AEFAGEEAAE SWKEIVNLLY ELLASLIRGN RANCALFCTN
     LDWLVSKLDR LEASSGILEV LYCVLIESPE VLNIIQENHI KSIISLLDKH GRNHKVLDVL
     CSLCVCNGVA VRSNQDLITE NLLPGRELLL QTNLINYVTS IRPNIFVGRA EGSTQYGKWY
     FEVMVDEVVP FLTAYPTHLR VGWALTEGYS PYPGGGEGWG GNGVGDDLYS YGFDGLHLWT
     GHVARPVTSP GQHLLAPDDV VSCCLDLSVP SISFRINGCP VQGVFEAFNL DGLFFPVVSF
     SAGVKVRFLL GGRHGEFKFL PPPGYAPCHE AVLPRERLRL EPIKEYRREG PRGPHLVGPS
     RCLSHTDFVP CPVDTVQIVL PPHLERIREK LAENIHELWA LTRIEQGWTY GPVRDDNKRL
     HPCLVDFHSL PEPERNYNLQ MSGETLKTLL ALGCHVGMAD EKAEDNLKKT KLPKTIQKVR
     TPKPGVWGSR VLRSERDQRS EIPTLRAKDH GTLGSRTRKQ WFHGSVMKLV KANHPPTLAN
     SSAIPQFFSN TKKLSLFPQS AKTLTFSDPS HLPPDTLEPS LVDRQSRWDR VRIFRAERSY
     AVQSGRWYFE FEAVTTGEMR VGWARPELRP DVELGADELA YVFNGHRGQR WHLGSEPFGR
     PWQPGDVVGC MIDLTENNII FTLNGEVLMS DSGSETAFRD IEIGDGFLPV CSLGPGQVGH
     LNLGQDVSSL RFFAICGLQE GFEPFAINMQ RPVTTWFSKS LPQFEAVPSE HPHYEVSRVD
     GTVDTPPCLR LTHRTWGSQN SLVEMLFLRL SLPVQFYQHF RCTAGATPLA PPGQQPPAED
     EARAAEPDPD YENLCRSAGR RGEAEMGKEG AAKEGAPGGT PQAGVEAQPT RVENEKDATT
     EKNKKRGFLF KAKKAAMMTQ PPATPTLPRL PHDVVPTDDR DDPEIILNTT TYYYSVRVFA
     GQEPSCVWVG WVTPDYHQHD MNFDLSKVRA VTVTMGDEHG NVHSSLKCSN CYMVWGGDFV
     SPGQQGRISH TDLIIGCLVD LATGLMTFTA NGKESNTFFQ VEPNTKLFPA LFVLPTHQNV
     VQFELGKLKN IMPLSAAMFL SERKNSAPQC PRLEVQMLMP ISWSRMPNHF LQVETRRAGE
     RLGWAVQCQE PLTMMALHIP EENRCMDILE LSERLDLQRF HSHTLRLYRA VCALGNNRVA
     HALCSHVDQA QLLHALEDAH LPGPLRAGYY DLLISIHLES ACRSRRTMLS EYIVPLTPET
     RAITLFPPGR GEDGGSRHHG LPGVGVSTSL RPPHHFLPPC FVAALPAAGA AEAPARLSPA
     IPLEALRDKA LRMLGEAVQD GRQHARDPVG GSVEFQFVPV LKLVSTLLVM GVFGDEDVKQ
     ILKMIDPEVF TAEGDKEEGL EEGLLQMKLP ESVKLQMCHL LEYFCDQELQ HRVESLAAFA
     ERYVDKLQAN QRGRYGLLMT AFNMTAAETA RRTREFRSPP QEQINMLLHF KDGVDEEDCS
     LPEEIRQYLL DFHQDLLAHC GIQLEGEEEE PEEEATLGSR LMSLLEKVRL VKKKEKPEEE
     PAAEESKPKS LQELVSHTVV RWAREDFVQS PELVRAMFSL LHRQYDGLGE LLRAMPRAYT
     ISPSSVDDTM SLLECLGQIR SLLIVQMGPQ EENLMIQSIG NIMNNRVFYQ HPNLMRALGM
     HETVMEVMVN VLGGGGGESK EIRFPKMVTS CCRFLCYFCR ISRQNQRSMF DHLSYLLENS
     GIGLGMQGST PLDVAAASVI DNNELALALQ EQDLEKVVSY LAGCGLQSCP MLLAKGYPDI
     GWNPCGGERY LDFLRFAVFV NGESVEENAN VVVRLLIRKP ECFGPALRGE GGSGLLAAIE
     EAIRISEDPA RDGPGVRRER RREHFGEEPP EENRVHLGHA IMSFYAALID LLGRCAPEMH
     LIQAGKGEAL RIRAILRSLV PLDDLVGIIS LPLQIPTLGK DGALVQPKMS ASFVPDHKAS
     MVLFLDRVYG IDSQDFLLHV LDVGFLPDMR AAASLDTATF STTEMALALN RYLCLAVLPL
     ITKCAPLFAG TEHRAIMVDS MLHTVYRLSR GRSLTKAQRD IIEDCLMALC RYIRPSMLQH
     LLRRLVFDVP ILNEFAKMPL KLLTNHYERC WKYYCLPTGW ANFGVTSEEE LHLTRKLFWG
     IFDSLAHKKY DPDLYRMAMP CLCAIAGALP PDYVDASYSS KAEKKATVDA EGNFDPRPVE
     TLNVDHPRRG LTPLLQVRRR YTHEKWGFDR LGIRGLMLGF TPSAHSINYP SSCPPQDKEI
     YRWPLTESQK DMIAWEWTIE KARGEEEKTE KKKTRKISQS AQTYDPREGY NPQPPDLSGV
     TLSRELQAMA EQLAENYHNT WGRKKKQELE AKGGGSHPLL VPYDTLTAKE KARDREKAQE
     LLKFLQMNGY AVTRGIVRAA GMPTDASGIP LRITAGAPMV PSNFPQRSRH PPNIPLRATP
     GTPKPPSVPI LSEPWFLYLI LLPLINQYFT NHCLYFLSTP AKVLGSGGHA SNKEKEMITS
     LFCKLAALVR HRVSLFGTDA PAVVNCLHIL ARSLDARTVM KSGPEIVKAG LRSFFESASE
     DIEKMVENLR LGKVSQARTQ VKGVGQNLTY TTVALLPVLT TLFQHIAQHQ FGDDVILDDV
     QVSCYRTLCS IYSLGTTKST YVEKEGRERG RRAQCANTVA AAVPKGSHLR ALRRKPATEG
     GPQLGPLAGQ HPRLHPAEDH QACPGRGHTE TKAVHWGHRT LVGSRETLGS AHVGSEGPRS
     PVEQEGSQEA WEKAIYKKCC ACPRGPAPVP CCLLISPPDR SCPFSLLYLL EPNLCLKSWL
     WEWFQFWANR VQGPHLLGSL RSQSDWVNRL DSSLFLPLRL SRKEGDKLHV HTDLSLWPPS
     LGTLPQALTD PPPLPRAHWL TAPNANAEEL FRMVGEIFIY WSKSHNFKRE EQNFVVQNEI
     NNMSFVEALW SRRTGWSGGS DQERTKKQRR GDRYSVQTSL IVATLKKMLP IGLNMCAPTD
     QELIMLAKTR YALKDTDEEV REYLQNNLHL QGKVEGSPSL RWQMALYRGL PGREEDADDP
     EKIVRRVQEV SAVLYHLEQM EHPYKSKKAV WHKLLSKQRR RAVVACFRMT PLYNLPTHRA
     CNMFLESYKA AWILTEDHSF EDRMIDDLSK LNKQEQIITA VEEGQGEGEG LVIVVEWAPA
     SFLSKLDEDY LYMAYADIMA KSCHLEEAEE NVNMNAEEEV EVSFEEKEME KQRLLYQQAR
     LHSRGAAEMV LQMISACKGE TGSMVSLHPE AGPSLNGGNA DVQQKMLDYL KDKKEVGFFQ
     SIQVLMQTCS VLDLNAFERQ NKAEGLGMVN EDGTVINRQN GEKVMADDEF TQDLFRFLQL
     LCEGHNNDFQ NYLRTQTGNT TTINIIICTV DYLLRLQESI SDFYWYYSGK DVIEEQGKRN
     FSKAMSVAKQ VFNSLTEYIQ GPCTGNQQSL AHSRLWDAVV GFLHVFAHMM MKLAQDSSQI
     ELLKELLDLQ KDMVVMLLSL LEGNVVNGMI ARQMVDMLVE SSSNVEMILK FFDMFLKLKD
     IVGSEAFQDY VTDPRGLISK KDFQKAMDSQ KQFTGPEIQF LLSCSEADEN EMINCDEFAN
     RFEEPARDIG FNVAVLLTNL SEHVPHDPRL RNFLELAESI LEYFRPYLGR IEIMGASRRI
     ERIYFEISET NRAQWEMPQV SRPAHVHACS AGLPCAWLVL AYSFCTLPLW ALVLSPQHPH
     TLPTSVYTRG PGTPPAQCPH RDCGFHPPPW HPPHAPYTPS APHHCPGSPS CYTGLARQAC
     VPLKLTLLLG SSQVPSTCTC ILLALAHPVS SSTCSPAGLR ALLNSRVPDV SSSVLMSHTE
     SCPHFPGPPD SPSVPRAPAR TPQELSSSGT LVSLGASLYT HPASGPHVTA PSLHPPDNSN
     NSQRYVERMP RMPRRAGGLG DMGDTTPAEP PTPEGSPILK RKLGVDGQEE ELPPEPEPEP
     EPEKADAENG EKEEVPEPPP EPPKKTAPPT PPPKKEEAKG GGMEFWGELE VQRVKFLNYL
     SRNFYTLRFL ALFLAFAINF ILLFYKVSDS PPGEDDMEGS AAGDLTGAGS GGGSGWGSGA
     GEEAEGDEDE NMVYYFLEES TGYMEPALRC LSLLHTLVAF LCIIGYNCLK VPLVIFKREK
     ELARKLEFDG LYITEQPEDD DVKGQWDRLV LNTPSFPSNY WDKFVKRKVL DKHGDIYGRE
     RIAELLGMDL ATLEITAHNE RKPKPPPGLL TWLMSIDVKY QIWKFGVIFT DNSFLYLGWY
     MVMSLLGHYN NFFFAAHLLD IAMGVKTLRT ILSSVTHNGK QLVMTVGLLA VVVYLYTVVA
     FNFFRKFYNK SEDEDEPDMK CDDMMTCYLF HMYVGVRAGG GIGDEIEDPA GDEYELYRVV
     FDITFFFFVI VILLAIIQGL IIDAFGELRD QQEQVKEDME TKCFICGIGS DYFDTTPHGF
     ETHTLEEHNL ANYMFFLMYL INKDETEHTG QESYVWKMYQ ERCWDFFPAG DCFRKQYEDQ
     LS
//
DBGET integrated database retrieval system