ID G3UG40_LOXAF Unreviewed; 396 AA.
AC G3UG40;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 45.
DE RecName: Full=SEA domain-containing protein {ECO:0008006|Google:ProtNLM};
OS Loxodonta africana (African elephant).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta.
OX NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000026798.1, ECO:0000313|Proteomes:UP000007646};
RN [1] {ECO:0000313|Ensembl:ENSLAFP00000026798.1, ECO:0000313|Proteomes:UP000007646}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000026798.1,
RC ECO:0000313|Proteomes:UP000007646};
RA Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Loxodonta africana (African elephant).";
RL Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLAFP00000026798.1}
RP IDENTIFICATION.
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000026798.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR AlphaFoldDB; G3UG40; -.
DR Ensembl; ENSLAFT00000031394.1; ENSLAFP00000026798.1; ENSLAFG00000029589.1.
DR GeneTree; ENSGT00940000154419; -.
DR HOGENOM; CLU_034264_1_0_1; -.
DR Proteomes; UP000007646; Unassembled WGS sequence.
DR GO; GO:0071944; C:cell periphery; IEA:UniProt.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR Gene3D; 2.10.25.10; Laminin; 1.
DR Gene3D; 3.30.70.960; SEA domain; 1.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000082; SEA_dom.
DR InterPro; IPR036364; SEA_dom_sf.
DR PANTHER; PTHR37999; MUCIN-17; 1.
DR PANTHER; PTHR37999:SF2; MUCIN-17; 1.
DR Pfam; PF01390; SEA; 1.
DR SMART; SM00200; SEA; 1.
DR SUPFAM; SSF82671; SEA domain; 1.
DR PROSITE; PS00022; EGF_1; 1.
DR PROSITE; PS50026; EGF_3; 1.
DR PROSITE; PS50024; SEA; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000007646};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 292..316
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 34..68
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 83..190
FT /note="SEA"
FT /evidence="ECO:0000259|PROSITE:PS50024"
FT DISULFID 58..67
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 396 AA; 44835 MW; 7C0A110F22ECDB2E CRC64;
VTKLVGTRAL SLSVICLNGG QWNGKVCECS TGFTGDQCQY AHRFCKNGGF WDGIKCQCTT
LYYGTECELL VESIEIEPPP AIVTAQVEIT VTVTSENFSE DLNNRSSQAF QKFKEIFTKQ
MEILYSGITE YEGVNIIRIT PGSVVVEHEV LLRTKFIPEY EKVLKNASQE VKEKIMTITN
EQIMVNNNCS DLLCFKENTT EVKSTEITQY DPEAECQEKA KEAGDYAQYF FVEYKDEKPN
CVTACMQGFN SSMDCNYGKC QLERSGPRCF CLTTDTHWYR GENCELSTQK SLVYGLVGAA
GAVVLVVFIA LLVFTLHSKR EVKRQKYKLS QLYKWYEEDG GQAPGTFQNI GFDIHEEREG
SINLDPIYSN FQPSLSHIDP ETKIQTQRPQ VVMTSF
//
